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miR (show MYLIP Proteins)-146a-5p targets porcine insulin receptor (show INSR Proteins) and could inhibit its protein expression.
TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 (show SLC2A4 Proteins) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
These effects were exerted by changes on the phosphorylation of IRS-1.
Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.
Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.
G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.
The results suggest that high glucose compromises the insulin (show INS Proteins) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.
The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.
IRS-1 and IRS-2 (show IRS2 Proteins) signaling interaction with the microtubule cytoskeleton and its response to AKT (show AKT1 Proteins) determines the response to microtubule disruption in breast carcinoma cells
Findings suggest that the induction of microRNA miR (show MLXIP Proteins)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS Proteins) resistance by targeting insulin receptor (INSR (show INSR Proteins)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.
The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (show INS Proteins), IRS2 (show IRS2 Proteins), PPAR-G (show ARF6 Proteins) and CAPN10 (show CAPN10 Proteins) failed to show any association with PCOS in our studied population.
Consistent with these observations, LPIN1 (show LPIN1 Proteins) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (show LPIN1 Proteins) may be a promising drug target for anticancer therapy
Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP Proteins)-342
Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.
In conclusion, we have identified that ARL15 acts as an insulin (show INS Proteins)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (show PDPK1 Proteins)/AKT (show AKT1 Proteins) insulin (show INS Proteins) pathway by interacting with its GAP ASAP2 (show ASAP2 Proteins) and activating PDPK1 (show PDPK1 Proteins). This research may provide new insights into GTPase (show RACGAP1 Proteins)-mediated insulin (show INS Proteins) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Proteins) sensitizati
These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (show INS Proteins) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation
Decreased miR (show MLXIP Proteins)-33 levels can up-regulate IRS-2 (show IRS2 Proteins) expression, which appears to compensate for the defects of the insulin (show INS Proteins) signaling pathway in Irs-1 deficient mice.
Acute knockdown of Insr (show INSR Proteins) or both Irs1 and Irs2 (show IRS2 Proteins) in adipocytes increased Adipoq (show ADIPOQ Proteins) mRNA expression but reduced adiponectin (show ADIPOQ Proteins) secretion.
Concentration of SOCS-3 (show SOCS3 Proteins) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 Proteins) protein with both the IR-beta subunit (show POLG Proteins) as well as IRS-1 was found to be decreased by 4-HIL
Authors propose that insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 Proteins) longevity phenotype.
within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 Proteins) signaling regulates Akt (show AKT1 Proteins) largely through IRS (show IARS Proteins)-independent means with little effect upon physiologic insulin (show INS Proteins) sensitivity.
Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A Proteins) development and progression.
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Proteins) genes regulates body weight in rabbits.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Proteins) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A