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Browse our Insulin Receptor Substrate 1 Proteins (IRS1)

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Insulin Receptor Substrate 1 Proteins (IRS1)
On are 6 Insulin Receptor Substrate 1 (IRS1) Proteins from 4 different suppliers available. Additionally we are shipping Insulin Receptor Substrate 1 Antibodies (593) and Insulin Receptor Substrate 1 Kits (45) and many more products for this protein. A total of 668 Insulin Receptor Substrate 1 products are currently listed.
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu
list all proteins Gene Name GeneID UniProt
IRS1 3667 P35568
IRS1 16367 P35569
Rat IRS1 IRS1 25467 P35570

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Insulin Receptor Substrate 1 Proteins (IRS1) by Origin

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More Proteins for Insulin Receptor Substrate 1 Interaction Partners

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 (show SLC2A4 Proteins) showed altered expression in some tissues in pre-diabetic pigs.

  2. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (show IRS2 Proteins) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR Proteins) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  2. IRS1 Gene Polymorphism is associated with Autism Spectrum Disorder.

  3. High IRS1 expression is associated with hepatocellular carcinoma.

  4. In the renal proximal tubule, insulin (show INS Proteins) signaling via IRS1 is inhibited, while insulin (show INS Proteins) signaling via IRS2 (show IRS2 Proteins) is preserved. Insulin (show INS Proteins) signaling via IRS2 (show IRS2 Proteins) continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.

  5. miR-195 inhibits tumor angiogenesis through suppressing IRS1-VEGF axis.

  6. The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of rheumatoid arthritis, and therefore may be a potential prognostic factor for RA.

  7. In this exploratory analysis, IRS1, ENNP1 and TRIB3 (show TRIB3 Proteins), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Proteins) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.

  8. In accordance with previous studies, our findings suggest that the IRS1 G972R R allele and RR+GR genotype have protective effects for colorectal cancer (CRC (show CALR Proteins)) in overweight/obese patients and for obesity in patients with CRC (show CALR Proteins).

  9. FRET-based translocation assays reveal that insulin (show INS Proteins) promotes the association of both p62 (show GTF2H1 Proteins) and aPKC with the insulin (show INS Proteins)-regulated scaffold IRS-1.

  10. HCV NS5A favors serine phosphorylation of IRS-1, promoting insulin (show INS Proteins) resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Acute knockdown of Insr (show INSR Proteins) or both Irs1 and Irs2 (show IRS2 Proteins) in adipocytes increased Adipoq (show ADIPOQ Proteins) mRNA expression but reduced adiponectin (show ADIPOQ Proteins) secretion.

  2. Concentration of SOCS-3 (show SOCS3 Proteins) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 Proteins) protein with both the IR-beta subunit (show POLG Proteins) as well as IRS-1 was found to be decreased by 4-HIL

  3. Authors propose that insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 Proteins) longevity phenotype.

  4. within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 Proteins) signaling regulates Akt (show AKT1 Proteins) largely through IRS (show IARS Proteins)-independent means with little effect upon physiologic insulin (show INS Proteins) sensitivity.

  5. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A Proteins) development and progression.

  6. Insulin receptor substrate-1-mediated insulin (show INS Proteins) signal transduction may be an important factor in the treatment of cognitive decline induced by insulin (show INS Proteins) resistance.

  7. Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation.

  8. melatonin can ameliorate insulin (show INS Proteins) sensitivity by inhibiting Ser307 phosphorylation in IRS-1

  9. Most importantly, treatment of cells with the RhoA (show RHOA Proteins)/ROCK inhibitor, Y-27632, which among its many effects also inhibited serine 636 phosphorylation of IRS-1, had profound effects on cell-substratum adhesion

  10. Results indicate that although IRS (show IARS Proteins) isoforms (irs1 and irs2 (show IRS2 Proteins)) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Proteins) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Proteins) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) Protein Profile

Protein Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2)
  • insulin receptor substrate 1 (IRS1)
  • insulin receptor substrate 1 (Irs1)
  • insulin receptor substrate 1 (irs1)
  • G972R protein
  • HIRS-1 protein
  • irs-1 protein
  • IRS1 protein
  • irs1-a protein
  • IRS1IRM protein
  • irsu protein

Protein level used designations for IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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