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TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 (show SLC2A4 Proteins) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
miR-195 inhibits tumor angiogenesis through suppressing IRS1-VEGF axis.
The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of rheumatoid arthritis, and therefore may be a potential prognostic factor for RA.
In this exploratory analysis, IRS1, ENNP1 and TRIB3 (show TRIB3 Proteins), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Proteins) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
In accordance with previous studies, our findings suggest that the IRS1 G972R R allele and RR+GR genotype have protective effects for colorectal cancer (CRC (show CALR Proteins)) in overweight/obese patients and for obesity in patients with CRC (show CALR Proteins).
FRET-based translocation assays reveal that insulin (show INS Proteins) promotes the association of both p62 (show GTF2H1 Proteins) and aPKC with the insulin (show INS Proteins)-regulated scaffold IRS-1.
HCV NS5A favors serine phosphorylation of IRS-1, promoting insulin (show INS Proteins) resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
High IRS1 Expression is associated with Colorectal Cancer.
failed to find any association between the IRS1 Gly972Arg polymorphism and T2DM
rs1801278 in IRS1 gene may play a role in type 2 diabetes risk, especially in Asian and rs2943641 may be associated with type 2 diabetes risk in Caucasian.[meta-analysis]
Upregulation of IRS1 was associated with metastasis of gastric carcinoma.
Acute knockdown of Insr (show INSR Proteins) or both Irs1 and Irs2 (show IRS2 Proteins) in adipocytes increased Adipoq (show ADIPOQ Proteins) mRNA expression but reduced adiponectin (show ADIPOQ Proteins) secretion.
Concentration of SOCS-3 (show SOCS3 Proteins) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 Proteins) protein with both the IR-beta subunit (show POLG Proteins) as well as IRS-1 was found to be decreased by 4-HIL
Authors propose that insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 Proteins) longevity phenotype.
within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 Proteins) signaling regulates Akt (show AKT1 Proteins) largely through IRS (show IARS Proteins)-independent means with little effect upon physiologic insulin (show INS Proteins) sensitivity.
Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A Proteins) development and progression.
Insulin receptor substrate-1-mediated insulin (show INS Proteins) signal transduction may be an important factor in the treatment of cognitive decline induced by insulin (show INS Proteins) resistance.
Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation.
melatonin can ameliorate insulin (show INS Proteins) sensitivity by inhibiting Ser307 phosphorylation in IRS-1
Most importantly, treatment of cells with the RhoA (show RHOA Proteins)/ROCK inhibitor, Y-27632, which among its many effects also inhibited serine 636 phosphorylation of IRS-1, had profound effects on cell-substratum adhesion
Results indicate that although IRS (show IARS Proteins) isoforms (irs1 and irs2 (show IRS2 Proteins)) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Proteins) genes regulates body weight in rabbits.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Proteins) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A