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TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 (show SLC2A4 Proteins) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
rs1801278 in IRS1 gene may play a role in type 2 diabetes risk, especially in Asian and rs2943641 may be associated with type 2 diabetes risk in Caucasian.[meta-analysis]
Upregulation of IRS1 was associated with metastasis of gastric carcinoma.
The G allele of rs13431554 in the IRS-1 gene was associated with a hyperreactive platelet phenotype in the coronary artery disease patients with T2DM.
miR (show MLXIP Proteins)-126 functions as a tumor suppressor in glioma cells by targeting IRS-1 expression via the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathways
Results showd that miR (show MLXIP Proteins)-128 was negatively associated with IRS1 in colorectal carcinoma (CRC (show CALR Proteins)) tissues and suggested that miR (show MLXIP Proteins)-128 serves as a tumor suppressor and blocks CRC (show CALR Proteins) growth and metastasis by targeting IRS1.
IRS (show IARS Proteins)-specific gene signatures represent accurate surrogates of IGF activity and could predict response to anti-IGF therapy in breast cancer.
Data suggest that IRS1 tyrosine phosphorylation, insulin (show INS Proteins) sensitivity, and glucose internalization in visceral adipocytes can be up-regulated by dietary components (here, protocatechuic acid, a metabolite of dietary anthocyanins).
genetic association studies in population in Austria: Data suggest that a haplotype upstream of IRS1 protects against insulin (show INS Proteins) resistance, type 2 diabetes, dyslipidemias, and atherosclerosis.
Arg972 IRS-1 inhibits endothelial nitric oxide synthase (show NOS3 Proteins) expression in human endothelial cells by upregulating miR (show MLXIP Proteins)-155 expression through the impairment of phosphatidylinositol-3 kinase signaling.
Alpha-Syn overexpression negatively regulated IRS-1 via mTORC1/S6K1 (show RPS6KB1 Proteins) signaling while activation of PP2A (show PPP2R4 Proteins) reverses this process.
Authors propose that insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 Proteins) longevity phenotype.
within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 Proteins) signaling regulates Akt (show AKT1 Proteins) largely through IRS (show IARS Proteins)-independent means with little effect upon physiologic insulin (show INS Proteins) sensitivity.
Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A Proteins) development and progression.
Insulin receptor substrate-1-mediated insulin (show INS Proteins) signal transduction may be an important factor in the treatment of cognitive decline induced by insulin (show INS Proteins) resistance.
Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation.
melatonin can ameliorate insulin (show INS Proteins) sensitivity by inhibiting Ser307 phosphorylation in IRS-1
Most importantly, treatment of cells with the RhoA (show RHOA Proteins)/ROCK inhibitor, Y-27632, which among its many effects also inhibited serine 636 phosphorylation of IRS-1, had profound effects on cell-substratum adhesion
Results indicate that although IRS (show IARS Proteins) isoforms (irs1 and irs2 (show IRS2 Proteins)) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.
precise regulation of IRS-1 expression level is critical for determining the differentiating capacity of mouse mesenchymal stem cells and osteosarcoma cells, and that derangement of IRS-1 levels can be a critical step in osteosarcoma transformation.
ectopic expression of miR (show MLXIP Proteins)-29a impairs insulin (show INS Proteins) signaling and glucose uptake in myocytes through a substantial decrease in IRS-1
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Proteins) genes regulates body weight in rabbits.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Proteins) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A