Browse our NR4A1 Proteins (NR4A1)

Full name:
Nuclear Receptor Subfamily 4, Group A, Member 1 Proteins (NR4A1)
On are 7 Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) Proteins from 4 different suppliers available. Additionally we are shipping NR4A1 Antibodies (199) and NR4A1 Kits (7) and many more products for this protein. A total of 226 NR4A1 products are currently listed.
Gfrp, GFRP1, Hbr-1, Hbr1, Hmr, N10, NAK-1, Ngfi-b, NGFIB, NP10, Nur77, TIS1, TR3
list all proteins Gene Name GeneID UniProt
NR4A1 3164 P22736
NR4A1 15370 P12813
NR4A1 79240 P22829

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NR4A1 Proteins (NR4A1) by Origin

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More Proteins for NR4A1 Interaction Partners

Human Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) interaction partners

  1. Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.

  2. Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 (show NR4A3 Proteins) or NR4A1 revealed that apoptosis was driven similarly by induction of BAK (show BAK1 Proteins), Puma (show BBC3 Proteins), BIK (show BIK Proteins), BIM (show BCL2L11 Proteins), BID (show BID Proteins), and Trail. Overall, our results showed that NR4A3 (show NR4A3 Proteins) possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas

  3. NR4A1 expression is specific to a quiescent subset of T-cells.

  4. we demonstrate that endogenous Nur77 protein expression can serve as a reporter of T-cell receptor and B-cell receptor specific signaling in human peripheral blood mononuclear cells.

  5. we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is sufficient to drive high expression of PAX3 (show PAX3 Proteins)-FOXO1A (show FOXO1 Proteins)

  6. Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1, NR4A2 (show NR4A2 Proteins), and NR4A3 (show NR4A3 Proteins)) obtained from Parkinson's disease patients, but only a NR4A1 decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 (show NR4A2 Proteins) could be systemically involved in Parkinson's disease.

  7. Nur77 overexpression prevented pulmonary artery smooth muscle cells from proliferation and migration; Nur77 is an important mediator of hypoxia-induced pulmonary vascular remodeling in pulmonary hypertension

  8. Data show Kruppel-like factor 12 (KLF12 (show KLF12 Proteins)) impairs endometrial decidualization by transcriptionally repressing Nur77 protein, and Nur77 overexpression reverses the poor decidual response of endometrial stromal cells (hESCs) in recurrent implantation failure (RIF) patients.

  9. Nur77 decreases ET-1 (show EDN1 Proteins) expression by suppressing NF-kappaB (show NFKB1 Proteins) and p38 MAPK (show MAPK14 Proteins).

  10. NR4A1 is highly expressed in a subset of HGSOC samples from patients that have a worse progression free survival.

Cow (Bovine) Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) interaction partners

  1. Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.

Mouse (Murine) Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) interaction partners

  1. current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.

  2. Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (show TRAF2 Proteins). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (show SQSTM1 Proteins), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.

  3. New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.

  4. Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.

  5. Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner.

  6. Nur77 was found to be an important modulator in microglia function and attenuated pro-inflammatory mediator production.

  7. this study shows that in NR4A1-/- mice, inflammatory Ly6Chigh monocytes contribute to rapid development of arthritis in a serum transfer-induced arthritis model

  8. Nur77 downregulation triggers pulmonary artery smooth muscle cell proliferation and migration in mice with hypoxic pulmonary hypertension

  9. Our findings may throw light on the function of ApoA4 (show APOA4 Proteins) in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 (show SERPINA3 Proteins) relative diseases.

  10. This study demonstrated that NGFI-B plays a role in controlling correct cerebellar development.

NR4A1 Protein Profile

Protein Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NR4A1

  • nuclear receptor subfamily 4, group A, member 1 (NR4A1)
  • nuclear receptor subfamily 4, group A, member 1 (Nr4a1)
  • Gfrp protein
  • GFRP1 protein
  • Hbr-1 protein
  • Hbr1 protein
  • Hmr protein
  • N10 protein
  • NAK-1 protein
  • Ngfi-b protein
  • NGFIB protein
  • NP10 protein
  • Nur77 protein
  • TIS1 protein
  • TR3 protein

Protein level used designations for NR4A1

ST-59 , TR3 orphan receptor , early response protein NAK1 , growth factor-inducible nuclear protein N10 , hormone receptor , nerve growth factor IB nuclear receptor variant 1 , nuclear hormone receptor NUR/77 , nuclear receptor subfamily 4 group A member 1 , orphan nuclear receptor HMR , orphan nuclear receptor TR3 , steroid receptor TR3 , testicular receptor 3 , orphan nuclear receptor NGFI-B , nuclear protein N10 , Orphan nuclear receptor HMR , immediate early gene transcription factor NGFI-B , nerve growth factor induced protein I-B , nerve growth factor-induced protein I-B

3164 Homo sapiens
403897 Canis lupus familiaris
528390 Bos taurus
15370 Mus musculus
79240 Rattus norvegicus
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