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mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
NR4A sub-family of nuclear orphan receptors (Nor-1 (show NR4A3 Proteins), Nurr-1 (show NR4A2 Proteins) and Nur-77) may have a role in trophoblastic cell differentiation.
beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 (show NR4A3 Proteins) or NR4A1 revealed that apoptosis was driven similarly by induction of BAK (show BAK1 Proteins), Puma (show BBC3 Proteins), BIK (show BIK Proteins), BIM (show BCL2L11 Proteins), BID (show BID Proteins), and Trail. Overall, our results showed that NR4A3 (show NR4A3 Proteins) possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
NR4A1 expression is specific to a quiescent subset of T-cells.
we demonstrate that endogenous Nur77 protein expression can serve as a reporter of T-cell receptor and B-cell receptor specific signaling in human peripheral blood mononuclear cells.
we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is sufficient to drive high expression of PAX3 (show PAX3 Proteins)-FOXO1A (show FOXO1 Proteins)
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1, NR4A2 (show NR4A2 Proteins), and NR4A3 (show NR4A3 Proteins)) obtained from Parkinson's disease patients, but only a NR4A1 decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 (show NR4A2 Proteins) could be systemically involved in Parkinson's disease.
Nur77 overexpression prevented pulmonary artery smooth muscle cells from proliferation and migration; Nur77 is an important mediator of hypoxia-induced pulmonary vascular remodeling in pulmonary hypertension
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
we found that KLF6 (show KLF6 Proteins) transcriptionally cooperates with NUR77 and SF1 (show SF1 Proteins)
Ca(2 (show CA2 Proteins)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (show MEF2C Proteins), AP1 (show JUN Proteins), and CREB (show CREB1 Proteins) transcription factors thus demonstrating an important interplay between the Ca(2 (show CA2 Proteins)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (show BCL2L11 Proteins) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (show TRAF2 Proteins). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (show SQSTM1 Proteins), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.
Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.
Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner.
Nur77 was found to be an important modulator in microglia function and attenuated pro-inflammatory mediator production.
this study shows that in NR4A1-/- mice, inflammatory Ly6Chigh monocytes contribute to rapid development of arthritis in a serum transfer-induced arthritis model
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B