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Browse our NR4A1 Proteins (NR4A1)

Full name:
Nuclear Receptor Subfamily 4, Group A, Member 1 Proteins (NR4A1)
On are 7 Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) Proteins from 4 different suppliers available. Additionally we are shipping NR4A1 Antibodies (157) and NR4A1 Kits (4) and many more products for this protein. A total of 182 NR4A1 products are currently listed.
Gfrp, GFRP1, Hbr-1, Hbr1, Hmr, N10, NAK-1, Ngfi-b, NGFIB, NP10, Nur77, TIS1, TR3
list all proteins Gene Name GeneID UniProt
NR4A1 3164 P22736
NR4A1 15370 P12813
NR4A1 79240 P22829

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NR4A1 Proteins (NR4A1) by Origin

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More Proteins for NR4A1 Interaction Partners

Human Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) interaction partners

  1. Mutagenesis of residues lining the identified interaction site on Bcl-B (show BCL2L10 Proteins) negated the interaction with Nur77 protein in cells and prevented Nur77-mediated modulation of apoptosis and autophagy

  2. NR4A1 regulates beta1-integrin expression and beta1-integrin-dependent migration of breast cancer cells, and this is accompanied by decreased expression of beta3-integrin (show ITGB3 Proteins).

  3. Data indicate that N-myc downstream regulated gene 1 (NDRG1 (show NDRG1 Proteins)) competitively bind to glycogen synthase kinase 3beta (GSK-3beta) and orphan nuclear receptor (Nur77) to prevent beta-catenin (show CTNNB1 Proteins) degradation.

  4. analysis of amino acid fragments required by TR3/Nur77 for its functions in angiogenesis

  5. The results demonstrate that Nur77 is induced by oxLDL via the p38 MAPK (show MAPK14 Proteins) signaling pathway, which is involved in the regulation of cell survival. Nur77 enhanced cell survival via suppressing apoptosis, without affecting cell proliferation of activated macrophages, which may be beneficial in patients with atherosclerosis.

  6. NR4As regulate gene transcription primarily through interaction with distal enhancers that are co-enriched for NR4A1 and ETS transcription factor (show FEV Proteins) motifs

  7. miR (show MLXIP Proteins)-124 to be downregulated in instances of medulloblastoma in which Nur77 is upregulated, resulting in a proliferative state that abets cancer progression.

  8. ApoA-IV (show APOA4 Proteins) colocalizes with NR4A1, which suppresses G6Pase (show G6PC Proteins) and PEPCK (show PEPCK Proteins) gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.

  9. NR4A1 is a key factor in multiple diseases, such as arthritis, inflammation, cancer and cardiovascular diseases.

  10. Identified Nur77/Nor1 (show NR4A3 Proteins) as novel regulators of thrombomodulin (show THBD Proteins) expression and function in vascular endothelial cells.

Cow (Bovine) Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) interaction partners

  1. Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.

Mouse (Murine) Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) interaction partners

  1. Nur77 modulates the inflammatory state of macrophages by decreasing inflammatory gene expression, inhibits the collagen content of the extracellular matrix of macrophages, and reduces phagocytosis by macrophages.

  2. Detailed knowledge on the role of Nur77 in maintaining cardiomyocyte Ca(2 (show CA2 Proteins)+) homeostasis and the dual role Nur77 plays in cardiac remodelling will aid in developing personalized therapies against heart failure

  3. NR4A1 functions as a master transcription factor for the development of this novel thymus-specific macrophage subset.

  4. Identified Nur77/Nor1 (show NR4A3 Proteins) as novel regulators of thrombomodulin (show THBD Proteins) expression and function in vascular endothelial cells.

  5. In both mouse colitis models inflammation was increased in Nur77-/- mice.Overexpression of Nur77 in lipopolysaccharide activated RAW macrophages up-regulated IL-10 and downregulated TNFalpha, MIF-1 and MCP-1 mRNA expression through NFkappaB repression.

  6. Nr4a1 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.

  7. Data show that transcription factor Nr4a1 expression in myeloid cells limits experimental autoimmune encephalomyelitis (EAE) severity.

  8. Nur77 is a critical negative regulator of Ang II (show AGT Proteins)-induced VSMC proliferation, migration, and phenotypic switching via the downregulation of beta-catenin (show CTNNB1 Proteins) activity

  9. Mechanistically, NFATc1 (show NFATC1 Proteins) induces Nur77 expression at late stage of osteoclast differentiation; in turn, Nur77 transcriptionally up-regulates E3 ubiquitin ligase (show MUL1 Proteins) Cbl-b, which triggers NFATc1 (show NFATC1 Proteins) protein degradation.

  10. Nr4a1 induction is dependent on ERK1/2 and that MKP-1 (show DUSP1 Proteins) negatively regulates this induction.

NR4A1 Protein Profile

Protein Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NR4A1

  • nuclear receptor subfamily 4, group A, member 1 (NR4A1)
  • nuclear receptor subfamily 4, group A, member 1 (Nr4a1)
  • Gfrp protein
  • GFRP1 protein
  • Hbr-1 protein
  • Hbr1 protein
  • Hmr protein
  • N10 protein
  • NAK-1 protein
  • Ngfi-b protein
  • NGFIB protein
  • NP10 protein
  • Nur77 protein
  • TIS1 protein
  • TR3 protein

Protein level used designations for NR4A1

ST-59 , TR3 orphan receptor , early response protein NAK1 , growth factor-inducible nuclear protein N10 , hormone receptor , nerve growth factor IB nuclear receptor variant 1 , nuclear hormone receptor NUR/77 , nuclear receptor subfamily 4 group A member 1 , orphan nuclear receptor HMR , orphan nuclear receptor TR3 , steroid receptor TR3 , testicular receptor 3 , orphan nuclear receptor NGFI-B , nuclear protein N10 , Orphan nuclear receptor HMR , immediate early gene transcription factor NGFI-B , nerve growth factor induced protein I-B , nerve growth factor-induced protein I-B

3164 Homo sapiens
403897 Canis lupus familiaris
528390 Bos taurus
15370 Mus musculus
79240 Rattus norvegicus
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