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Browse our TRIB3 Proteins (TRIB3)

Full name:
Tribbles Homolog 3 (Drosophila) Proteins (TRIB3)
On are 8 Tribbles Homolog 3 (Drosophila) (TRIB3) Proteins from 5 different suppliers available. Additionally we are shipping TRIB3 Antibodies (137) and TRIB3 Kits (7) and many more products for this protein. A total of 164 TRIB3 products are currently listed.
C20orf97, Ifld2, Nipk, SINK, SKIP3, TRB-3, Trb3, TRIB3, zgc:76966
list all proteins Gene Name GeneID UniProt
TRIB3 57761 Q96RU7
TRIB3 228775 Q8K4K2
TRIB3 246273 Q9WTQ6

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TRIB3 Proteins (TRIB3) by Origin

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Top referenced TRIB3 Proteins

  1. Human TRIB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2003320 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
    Show all 4 references for ABIN2003320

More Proteins for TRIB3 Interaction Partners

Zebrafish Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development

Human Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. In this exploratory analysis, IRS1 (show IRS1 Proteins), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Proteins) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.

  2. TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target

  3. TRB3 is upregulated in macrophages upon treatment with ox-LDL. TRB3 promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.

  4. Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 (show TRIB2 Proteins) and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.

  5. Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 (show TRIB2 Proteins) and TRIB3 were involved in the pathogenesis of inflammation.

  6. Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 (show TRIB2 Proteins) and TRIB3 in cells and intact organisms, serving as guides for the development of new drugs.

  7. Studies suggest that the tribbles homolog 3 (Drosophila) protein (TRIB3) Q84R missense polymorphis contributes to atherosclerosis.

  8. Studies show a remarkable reduction in tribbles (show TRIB1 Proteins) 2 protein (Trib2 (show TRIB2 Proteins)) expression during oocyte maturation whereas tribbles (show TRIB1 Proteins) 1 protein (Trib1 (show TRIB1 Proteins)) and tribbles 3 protein (Trib3) expression was significantly increased during this process.

  9. Studies show that tribbles (show TRIB1 Proteins) pseudokinase 3 (TRIB3) plays a crucial role in the anti-cancer activity of cannabinoids and that TRIB3 genetic inactivation enhances cancer generation and progression.

  10. TRB3 is an important mediator of palmitate-induced apoptosis in human liver cells, suggesting that it may also be involved in the molecular mechanism underlying PNALD.

Mouse (Murine) Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. Palmitate increased TRB3 expression, activated IRE1alpha (show ERN1 Proteins) signaling, and reduced the insulin (show INS Proteins)-dependent Akt (show AKT1 Proteins) phosphorylation. Knocking down TRB3 or IRE1alpha (show ERN1 Proteins) did not prevent the inhibitory effect of palmitate on Akt (show AKT1 Proteins) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.

  2. These data demonstrate that TRB3 inhibits insulin (show INS Proteins) signaling in BAT (show BAAT Proteins), resulting in impaired differentiation and function.

  3. TRB3 is a novel profibrotic mediator in SSc (show CYP11A1 Proteins). TGF-beta (show TGFB1 Proteins) induces TRB3, which in turn activates canonical TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta (show TGFB1 Proteins) signalling in SSc (show CYP11A1 Proteins).

  4. study presents the finding that activation of the NF-kappaB (show NFKB1 Proteins) pathway by Porphyromonas endodontalis LPS (show TLR4 Proteins) is important for Wnt5a (show WNT5A Proteins) expression in osteoblasts, and that TRIB3 may modulate the sustained expression of Wnt5a (show WNT5A Proteins) in osteoblasts stimulated by P. endodontalis

  5. TRIB1 (show TRIB1 Proteins) and TRIB3 are more strongly expressed than TRIB2 (show TRIB2 Proteins) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.

  6. Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin (show PARK2 Proteins) to mediate death

  7. These observations support the notion that loss of TRIB3 is associated with a more aggressive phenotype in various types of tumors by enhancing the activity of the mTORC2 (show CRTC2 Proteins)/AKT (show AKT1 Proteins)/FOXO (show FOXO3 Proteins) axis.

  8. This study showed that hepatic PSAT1 (show PSAT1 Proteins) expression and liver serine levels are reduced in 2 mouse strains, and that PSAT1 (show PSAT1 Proteins) inhibited the expression of hepatic TRB3 in vitro and in vivo.

  9. Tribbles 3 regulates the fibrosis cytokine TGF- beta 1 (show TGFB1 Proteins) through ERK1/2-MAPK (show MAPK1 Proteins) signaling pathway in diabetic nephropathy.

  10. Fibroblasts from two long-lived mice mutants (Snell dwarf (show POU1F1 Proteins) and PAPP-A (show PAPPA Proteins) knockout) expressed higher levels of TRB3 (a ATF4 (show ATF4 Proteins) target gene) during stress, suggesting a connection to longevity.

Pig (Porcine) Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.

TRIB3 Protein Profile

Protein Summary

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.

Alternative names and synonyms associated with TRIB3

  • tribbles homolog 3 (Drosophila) (trib3)
  • tribbles homolog 3 (Drosophila) (TRIB3)
  • tribbles 3 (TRIB3)
  • tribbles homolog 3 (Drosophila) (Trib3)
  • C20orf97 protein
  • Ifld2 protein
  • Nipk protein
  • SINK protein
  • SKIP3 protein
  • TRB-3 protein
  • Trb3 protein
  • TRIB3 protein
  • zgc:76966 protein

Protein level used designations for TRIB3

tribbles homolog 3 , tribbles homolog 3 (Drosophila) , tribbles homolog 3-like , TRB-3 , neuronal cell death inducible putative kinase , neuronal cell death-inducible putative kinase , p65-interacting inhibitor of NF-kappa-B , p65-interacting inhibitor of NF-kappaB , induced in fatty liver dystrophy 2 , Neuronal cell death Inducible Putative Kinase , kinase , tribbles 3

405805 Danio rerio
714636 Macaca mulatta
100439080 Pongo abelii
100603917 Nomascus leucogenys
745623 Pan troglodytes
57761 Homo sapiens
485819 Canis lupus familiaris
228775 Mus musculus
246273 Rattus norvegicus
538465 Bos taurus
100518810 Sus scrofa
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