Browse our TRIB3 Proteins (TRIB3)

Full name:
Tribbles Homolog 3 (Drosophila) Proteins (TRIB3)
On are 8 Tribbles Homolog 3 (Drosophila) (TRIB3) Proteins from 5 different suppliers available. Additionally we are shipping TRIB3 Antibodies (138) and TRIB3 Kits (9) and many more products for this protein. A total of 168 TRIB3 products are currently listed.
C20orf97, Ifld2, Nipk, SINK, SKIP3, TRB-3, Trb3, TRIB3, zgc:76966
list all proteins Gene Name GeneID UniProt
TRIB3 57761 Q96RU7
TRIB3 228775 Q8K4K2
TRIB3 246273 Q9WTQ6

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TRIB3 Proteins (TRIB3) by Origin

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Top referenced TRIB3 Proteins

  1. Human TRIB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2003320 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
    Show all 4 references for 2003320

More Proteins for TRIB3 Interaction Partners

Zebrafish Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development

Human Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. TRIB3 promotes acute promyelocytic leukemia (show PML Proteins) progression through stabilization of the oncoprotein PML (show PML Proteins)-RARalpha (show RARA Proteins) and inhibition of p53 (show TP53 Proteins)-mediated senescence.

  2. Downregulation of TRIB3 is associated with lung cancer.

  3. This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (show SEMA3E Proteins) and what effect semaphorin 3E (show SEMA3E Proteins) exerts on carotid atherosclerosis.

  4. overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.

  5. Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele.

  6. In this exploratory analysis, IRS1 (show IRS1 Proteins), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Proteins) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.

  7. TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target

  8. TRB3 is upregulated in macrophages upon treatment with ox-LDL. TRB3 promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.

  9. Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 (show TRIB2 Proteins) and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.

  10. Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 (show TRIB2 Proteins) and TRIB3 were involved in the pathogenesis of inflammation.

Mouse (Murine) Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. Chac1 (show CHAC1 Proteins) expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 (show CHAC1 Proteins) during arsenite stress.

  2. Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.

  3. In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.

  4. Palmitate increased TRB3 expression, activated IRE1alpha (show ERN1 Proteins) signaling, and reduced the insulin (show INS Proteins)-dependent Akt (show AKT1 Proteins) phosphorylation. Knocking down TRB3 or IRE1alpha (show ERN1 Proteins) did not prevent the inhibitory effect of palmitate on Akt (show AKT1 Proteins) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.

  5. These data demonstrate that TRB3 inhibits insulin (show INS Proteins) signaling in BAT (show BAAT Proteins), resulting in impaired differentiation and function.

  6. TRB3 is a novel profibrotic mediator in SSc (show CYP11A1 Proteins). TGF-beta (show TGFB1 Proteins) induces TRB3, which in turn activates canonical TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta (show TGFB1 Proteins) signalling in SSc (show CYP11A1 Proteins).

  7. study presents the finding that activation of the NF-kappaB (show NFKB1 Proteins) pathway by Porphyromonas endodontalis LPS (show TLR4 Proteins) is important for Wnt5a (show WNT5A Proteins) expression in osteoblasts, and that TRIB3 may modulate the sustained expression of Wnt5a (show WNT5A Proteins) in osteoblasts stimulated by P. endodontalis

  8. TRIB1 (show TRIB1 Proteins) and TRIB3 are more strongly expressed than TRIB2 (show TRIB2 Proteins) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.

  9. Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin (show PARK2 Proteins) to mediate death

  10. These observations support the notion that loss of TRIB3 is associated with a more aggressive phenotype in various types of tumors by enhancing the activity of the mTORC2 (show CRTC2 Proteins)/AKT (show AKT1 Proteins)/FOXO (show FOXO3 Proteins) axis.

Pig (Porcine) Tribbles Homolog 3 (Drosophila) (TRIB3) interaction partners

  1. This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.

TRIB3 Protein Profile

Protein Summary

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.

Alternative names and synonyms associated with TRIB3

  • tribbles homolog 3 (Drosophila) (trib3)
  • tribbles homolog 3 (Drosophila) (TRIB3)
  • tribbles 3 (TRIB3)
  • tribbles homolog 3 (Drosophila) (Trib3)
  • C20orf97 protein
  • Ifld2 protein
  • Nipk protein
  • SINK protein
  • SKIP3 protein
  • TRB-3 protein
  • Trb3 protein
  • TRIB3 protein
  • zgc:76966 protein

Protein level used designations for TRIB3

tribbles homolog 3 , tribbles homolog 3 (Drosophila) , tribbles homolog 3-like , TRB-3 , neuronal cell death inducible putative kinase , neuronal cell death-inducible putative kinase , p65-interacting inhibitor of NF-kappa-B , p65-interacting inhibitor of NF-kappaB , induced in fatty liver dystrophy 2 , Neuronal cell death Inducible Putative Kinase , kinase , tribbles 3

405805 Danio rerio
714636 Macaca mulatta
100439080 Pongo abelii
100603917 Nomascus leucogenys
745623 Pan troglodytes
57761 Homo sapiens
485819 Canis lupus familiaris
228775 Mus musculus
246273 Rattus norvegicus
538465 Bos taurus
100518810 Sus scrofa
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