Browse our CNR1 Proteins (CNR1)

On are 8 Cannabinoid Receptor 1 (CNR1) Proteins from 3 different suppliers available. Additionally we are shipping CNR1 Antibodies (171) and CNR1 Kits (38) and many more products for this protein. A total of 228 CNR1 products are currently listed.
CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, CNR1, cnr1-A, LOC540382, SKR6R
list all proteins Gene Name GeneID UniProt
CNR1 1268 P21554
CNR1 25248 P20272
CNR1 12801 P47746

CNR1 Proteins (CNR1) by Origin

More Proteins for CNR1 Interaction Partners

Cow (Bovine) Cannabinoid Receptor 1 (CNR1) interaction partners

  1. Anandamide, through CB1 and TRPV1 (show TRPV1 Proteins) activation, is involved in sperm release from the oviductal reservoir.

Zebrafish Cannabinoid Receptor 1 (CNR1) interaction partners

  1. genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 Proteins)) activity disrupts liver development and metabolic function in zebrafish.

  2. CB1 function is required in the early embryo for axonal growth and fasciculation.

Human Cannabinoid Receptor 1 (CNR1) interaction partners

  1. propose here a possible unifying theory of CB1 receptor functions.

  2. Patients with schizophrenia showed increased CB1A expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls.

  3. our systematic review on potential associations of CNR1 polymorphisms with schizophrenia and its subphenotypes revealed conflicting data, with results tending towards a negative association.

  4. Our study disclosed an increased risk of CVS among individuals with AG and GG genotypes of CNR1 rs806380 ( P <0.01), whereas the CC genotype of CNR1 rs806368 was associated with a decreased risk of CVS ( P <0.05). In addition CT and CC genotypes of CNR1 rs806368 were associated with a family history of migraines.

  5. U46619 and ANG II (show AGT Proteins) may stimulate rapid endothelial release of endocannabinoids (mainly 2-arachidonoylglycerol), leading to CB1 receptor-dependent and/or CB1 receptor-independent vasorelaxation, which in the negative feedback mechanism reduces later agonist-induced vasoconstriction.

  6. Data suggest that signaling via endocannabinoids and CNR1/CNR2 plays central role in food intake; the endocannabinoid system regulates bidirectional communication (in the context of energy intake and storage) between the brain and peripheral tissues (adipose tissue, liver, gastrointestinal tract, endocrine pancreas, and skeletal muscle). [REVIEW]

  7. Selective estrogen receptor (ER (show ESR1 Proteins)) modulator (SERM) isomers exhibit distinct affinity and selectivity for cannabinoid subtype 1 and 2 receptors (CB1R and CB2Rs).

  8. We investigated the relationship between variation in the CNR1, CNR2 (show CNR2 Proteins), and FAAH (show FAAH Proteins) genes and change in primary anxiety disorder severity. Five SNPs were nominally associated with a poorer treatment response (rs806365 [CNR1]; rs2501431 [CNR2 (show CNR2 Proteins)]; rs2070956 [CNR2 (show CNR2 Proteins)]; rs7769940 [CNR1]; rs2209172 [FAAH (show FAAH Proteins)]) and one with a more favorable response (rs6928813 [CNR1]).

  9. our results support the notion that palmitoylation of cysteine 415 modulates the conformational state of helix 8 and influences the interactions of CB1 receptor with cholesterol and caveolin 1 (show CAV1 Proteins), suggesting that the palmitoyl chain may serve as a functional interface for CB1 receptor localization and function.

  10. we investigated whether the effect of the CB1 receptor coding CNR1 gene on migraine and its symptoms is conditional on life stress. We covered the CNR1 gene with 11 SNPs. None of the SNPs showed main genetic effects on possible migraine or its symptoms. 5 SNPs showed nominally significant interaction with recent negative life events on headache with nausea

Mouse (Murine) Cannabinoid Receptor 1 (CNR1) interaction partners

  1. analysis of the composition and differences of CB1 protein complexes in glutamatergic neurons and in GABAergic interneurons in hippocampal mouse tissue by proteomics

  2. Identification of mouse CB1 receptor splice variants may help to explain differences found between human and mouse endocannabinoid systems and improve the understanding of CB1 receptor signaling and trafficking in different species

  3. our results reveal that ERRgamma (show ESRRG Proteins), induced via activation of the hepatic CB1 receptor, is a regulator of hepatic FGF21 (show FGF21 Proteins) gene expression and secretion.

  4. Morphine-induced conditioned place preference (CPP) elevated Cannabinoid CB1 receptor (CB1R) expression both in the nucleus accumbens and hippocampus. AM251 attenuated morphine-induced CPP and CB1R expression in the NAc and Hippocampus. CB1R mediated downstream ERK (show EPHB2 Proteins)-CREB (show CREB1 Proteins)-BDNF (show BDNF Proteins) signaling is implicated in morphine reward.

  5. In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD Proteins) muscarinic receptor (show CHRM5 Proteins) subtypes was also analyzed in brain areas involved in anxiety and cognition.

  6. A bidirectional link was found between the CB1 receptor and microRNA let-7d involved in the regulation of cannabinoid signaling.

  7. Study investigated the impact of the CB1 receptor ligands on the symptoms typical for schizophrenia. Antipsychotic-like effects induced by CB1 receptor antagonist, obtained in our research, confirm the potential effect of CB1 receptor blockade and could have important therapeutic implications on clinical settings, in the future.

  8. CB1 activation enhances protein synthesis via the mTOR (show FRAP1 Proteins) pathway, resulting in long-term depression of inhibitory transmission in GABA-ergic presynaptic interneuron axons.

  9. Decreased expression of CB1 receptor was found in the cingulate cortex of animals exposed to chronic unpredictable stress.

  10. CB1 involvement in the posttraumatic stress disorder-alcohol interaction

Pig (Porcine) Cannabinoid Receptor 1 (CNR1) interaction partners

  1. The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways

Rhesus Monkey Cannabinoid Receptor 1 (CNR1) interaction partners

Xenopus laevis Cannabinoid Receptor 1 (CNR1) interaction partners

  1. A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK (show PRKAA2 Proteins)-dependent inhibition of NKCC1 (show SLC12A2 Proteins) activity.

  2. CB1 functionality increased with development at both central and peripheral level.

CNR1 Protein Profile

Protein Summary

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

Alternative names and synonyms associated with CNR1

  • cannabinoid receptor 1 (brain) (CNR1)
  • cannabinoid receptor 1 (cnr1)
  • cannabinoid receptor 1 (LOC540382)
  • cannabinoid receptor 1 (brain) (Cnr1)
  • cannabinoid receptor 1 (brain) (cnr1)
  • CANN6 protein
  • CB-R protein
  • CB1 protein
  • CB1A protein
  • CB1K5 protein
  • CB1R protein
  • CNR protein
  • CNR1 protein
  • cnr1-A protein
  • LOC540382 protein
  • SKR6R protein

Protein level used designations for Cannabinoid Receptor 1 Proteins (CNR1)

cannabinoid receptor 1 (brain) , cannabinoid receptor (brain) , CB1R , cb1 , cannabinoid receptor 1 , cannabinoid receptor 1-like , central cannabinoid receptor , CB-R , CB1 , brain-type cannabinoid receptor , striatal cannabinoid receptor type 1 protein , cannabinoid 1 receptor , CB1 cannabinoid receptor , cannabinoid receptor CB-1 , cannabinoid receptor 1/CB1

281087 Bos taurus
404209 Danio rerio
540382 Bos taurus
100065681 Equus caballus
100393865 Callithrix jacchus
100483374 Ailuropoda melanoleuca
1268 Homo sapiens
25248 Rattus norvegicus
12801 Mus musculus
481913 Canis lupus familiaris
493926 Felis catus
100169690 Cavia porcellus
100520160 Sus scrofa
100299449 Bos taurus
428633 Gallus gallus
101111639 Ovis aries
751607 Taeniopygia guttata
472066 Pan troglodytes
574142 Macaca mulatta
373759 Xenopus laevis
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