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Browse our Tryptophan Hydroxylase 1 Proteins (TPH1)

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Tryptophan Hydroxylase 1 Proteins (TPH1)
On are 8 Tryptophan Hydroxylase 1 (TPH1) Proteins from 5 different suppliers available. Additionally we are shipping Tryptophan Hydroxylase 1 Antibodies (155) and Tryptophan Hydroxylase 1 Kits (33) and many more products for this protein. A total of 201 Tryptophan Hydroxylase 1 products are currently listed.
LOC100229598, SERGEF, Tph, tph1, tphD1, TPRH, TRPH
list all proteins Gene Name GeneID UniProt
TPH1 7166 P17752
TPH1 24848 P09810
TPH1 21990 P17532

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Tryptophan Hydroxylase 1 Proteins (TPH1) by Origin

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Top referenced Tryptophan Hydroxylase 1 Proteins

  1. Human Tryptophan Hydroxylase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2004899 : Allen, Bagade, McQueen, Ioannidis, Kavvoura, Khoury, Tanzi, Bertram: Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. in Nature genetics 2008 (PubMed)

More Proteins for Tryptophan Hydroxylase 1 Interaction Partners

Caenorhabditis elegans (C. elegans) Tryptophan Hydroxylase 1 (TPH1) interaction partners

  1. A gene-expression-based neural code for food abundance that modulates lifespan includes daf-7 that primarily regulates gene-expression variability, while tph-1 primarily regulates the dynamic range of gene-expression responses.

  2. tph-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans

Human Tryptophan Hydroxylase 1 (TPH1) interaction partners

  1. Associations between serotonin transporter (show SLC6A4 Proteins) gene and tryptophan hydroxylase 1 polymorphisms and several Temperament and Character Inventory dimensions and subdimensions were revealed in subjects with bipolar disorder.

  2. there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR (show SLC6A4 Proteins) S+ gene polymorphisms in opiate-dependent, but not in alcohol-dependent patients.

  3. Polymorphisms in the TPH1 gene may be represented by diminished activity in lateral areas of the PFC (show CFP Proteins) underlying response inhibition.

  4. Decoy receptor 3 (show TNFRSF6B Proteins) regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts

  5. TPH1 is functionally expressed in human coronary artery smooth muscle cells.

  6. This review showed no evidence for the association of antidepressant response with an A218C SNP in the TPH1 gene.

  7. The study provides evidence that A218C/A779C TPH-1 variants may be a risk factor to manifest suicidal behavior at the clinical level, which is in agreement with previously reported meta-analyses.[review and meta-analysis]

  8. TPH1 gene polymorphisms and S100A10 (show S100A10 Proteins) expression, which correlate with 5-HT (show DDC Proteins) signaling were associated with ramosetron effectiveness in IBS-D, and may possibly lead to prospective identification of the resistance to treatment.

  9. no significant effects on group differences or effects of exercise interventions for most of the biological parameters, that is, IL-6 (show IL6 Proteins), neopterin, 5-HIAA and tryptophan

  10. Tph1 and increased EC cell number occurred before the onset of obesity and hyperleptinemi. In addition, leptin (show LEP Proteins) deficiency was associated with reduced Pax4 (show PAX4 Proteins) mRNA, oral leptin (show LEP Proteins) treatment enhanced both Tph1 and Pax4 (show PAX4 Proteins) mRNA.

Mouse (Murine) Tryptophan Hydroxylase 1 (TPH1) interaction partners

  1. Prolactin (show PRL Proteins)-induced Tph1 expression.

  2. Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by brown adipose tissue.

  3. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.

  4. ZBP-89 (show ZNF148 Proteins) directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression.

  5. TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT (show DDC Proteins) is pivotal in AAI and lack of 5-HT (show DDC Proteins) leads to impaired Th2 priming capacity of bone marrow dendritic cells.

  6. Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis.

  7. Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity.

  8. Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo.

  9. nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin

  10. Review. TPH1 is expressed in the pineal gland and the enterochromaffin cells. Loss of TPH1 gene expression, and thus of peripheral 5-HT (show DDC Proteins), leads to a cardiac dysfunction phenotype.

Tryptophan Hydroxylase 1 (TPH1) Protein Profile

Protein Summary

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

Alternative names and synonyms associated with Tryptophan Hydroxylase 1 (TPH1)

  • tryptophan hydroxylase 1 (tph1)
  • tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a (tph1a)
  • TryPtophan Hydroxylase (tph-1)
  • tryptophan hydroxylase 1 (TPH1)
  • tryptophan hydroxylase 1 (LOAG_02149)
  • tryptophan hydroxylase 1 (LOC100229598)
  • tryptophan hydroxylase (Tph)
  • tryptophan 5-hydroxylase 1 (Tsp_05203)
  • tryptophan hydroxylase 1 (Tph1)
  • LOC100229598 protein
  • SERGEF protein
  • Tph protein
  • tph1 protein
  • tphD1 protein
  • TPRH protein
  • TRPH protein

Protein level used designations for TPH1

tryptophan 5-hydroxylase , tryptophan 5-monooxygenase , tph1-1 , tryptophan hydroxylase (tryptophan 5-monooxygenase , TryPtophan Hydroxylase family member (tph-1) , tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) , tryptophan hydroxylase 1 , tryptophan 5-hydroxylase 1-like , tryptophan hydroxylase , tryptophan 5-hydroxylase 1 , L-tryptophan hydroxylase , indoleacetic acid-5-hydroxylase , tryptophan 5-monooxygenase 1 , tryptophan hydroxylase (tryptophan 5-monooxygenase) , secretion regulating guanine nucleotide exchange factor

387560 Xenopus laevis
352943 Danio rerio
174227 Caenorhabditis elegans
695363 Macaca mulatta
9939535 Loa loa
100056614 Equus caballus
100229598 Taeniopygia guttata
100415029 Callithrix jacchus
100467699 Ailuropoda melanoleuca
100511002 Sus scrofa
100534573 Oreochromis niloticus
100601780 Nomascus leucogenys
10908943 Trichinella spiralis
7166 Homo sapiens
100101558 Oryctolagus cuniculus
24848 Rattus norvegicus
21990 Mus musculus
611956 Canis lupus familiaris
781941 Bos taurus
395799 Gallus gallus
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