Browse our Decorin Proteins (DCN)

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Decorin Proteins (DCN)
On are 27 Decorin (DCN) Proteins from 10 different suppliers available. Additionally we are shipping Decorin Antibodies (176) and Decorin Kits (73) and many more products for this protein. A total of 290 Decorin products are currently listed.
cscd, DC, DCN, dspg2, mDcn, pg40, pgii, pgs2, slrr1b
list all proteins Gene Name GeneID UniProt
DCN 1634 P07585
DCN 13179 P28654
Rat DCN DCN 29139 Q01129

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Decorin Proteins (DCN) by Origin

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Top referenced Decorin Proteins

  1. Human Decorin Protein expressed in Human Cells - ABIN2002301 : Li, Pennisi, Yaccoby: Role of decorin in the antimyeloma effects of osteoblasts. in Blood 2008 (PubMed)
    Show all 5 references for 2002301

  2. Human Decorin Protein expressed in Wheat germ - ABIN1351201 : Khan, Girish, Lala, Di Guglielmo, Lala: Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast. in Molecular endocrinology (Baltimore, Md.) 2011 (PubMed)
    Show all 4 references for 1351201

  3. Human Decorin Protein expressed in HEK-293 Cells - ABIN2180962 : Santra, Reed, Iozzo: Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. in The Journal of biological chemistry 2002 (PubMed)

More Proteins for Decorin Interaction Partners

Human Decorin (DCN) interaction partners

  1. Decorin exhibits promiscuity in its ability to alter tumorigenesis via regulation of angiogenesis, autophagy, and inflammation. (Review)

  2. Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (show BGN Proteins) (p = 0.0008) and Lumican (show LUM Proteins) (p = 0.01) and lower expression of Decorin (p < 0.0001) in urothelial carcinoma of bladder

  3. decorin can alter the bioactivity of TGF-beta2 (show TGFB2 Proteins) on human myoblast migration

  4. A Finnish cohort of 336 subjects with diagnosed hypertension and 444 controls was analyzed. Samples were genotyped for decorin rs7308752 and rs516115 polymorphisms. The GG genotype of the decorin polymorphism rs7308752 (A>G) and the CC genotype of the rs516115 (T>C) are associated with decreased plasma resistin (show RETN Proteins) levels. These two decorin polymorphisms appear to have biological relevance in human vascular pathophysiology.

  5. analysis of decorin and lumican (show LUM Proteins) expression in fibroblasts correlated with palmoplantar collagen bundle size

  6. via gain-of-function analyses, DCN overexpression could inhibit renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) cell proliferation and metastasis in vitro and vivo. At the mechanism level, we found that an ectopic expression of DCN significantly upregulated P21 (show CDKN1A Proteins) and E-cadherin (show CDH1 Proteins) expression. Altogether, these results revealed that DCN is a tumor suppressor in RCC (show XRCC1 Proteins), and it could serve as a potential therapeutic target in patients with RCC (show XRCC1 Proteins).

  7. Internal mammary artery tissue from active smokers contains decreased amounts of type 1 collagen and decorin.

  8. A synthetic peptide corresponding to this decorin region dose-dependently inhibited the response to myostatin (show MSTN Proteins) in cardiomyocytes

  9. increased blood DCN levels could be a candidate biomarker for PE.

  10. An emerging concept that multiple proteases, especially those produced by inflammatory cells, are capable of cleaving DCN suggests that native DCN could be inactivated in a number of pathological inflammatory conditions

Cow (Bovine) Decorin (DCN) interaction partners

  1. The inclusion of decorin proteoglycan during fibrillogenesis of type I collagen increases the modulus and tensile strength of resulting collagen gels.

  2. These findings reveal a novel role of DCN as an antagonistic ligand for VEGFR-2 (show KDR Proteins).

  3. Data show that biglycan (show BGN Proteins), collagen type I, collagen type II, decorin, and versican (show Vcan Proteins) were significantly affected by vibration duration, frequency, and amplitude.

  4. Results suggest that decorin contributes to the formation and stabilization of collagen fibres in the perimysium that support muscle fibres assembled with myogenesis.

  5. decorin is a dimer in solution

  6. decorin-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process

  7. Transduced bovine decorin synthesized de novo by rat arterial smooth muscle cells increases type I collagen synthesis and enhances contraction of collagen gels.

  8. The results indicate that CTGF (show CTGF Proteins) suppresses the synthesis of biglycan (show BGN Proteins) but newly induced that of decorin in the cells when the cell density is low.

  9. a novel collagen binding domain in decorin acts cooperatively with leucine-rich repeat 4 to mask the alpha2beta1 integrin-binding site on collagen, an important sequence for the phagocytosis of collagen fibrils

  10. analysis of decorin from different bovine tissues

Mouse (Murine) Decorin (DCN) interaction partners

  1. Fibroblasts differentiated to adipocytes and treated with TIP39 (show TFIP11 Proteins) also showed increased decorin and production of chondroitin sulfate. Furthermore, the skin of PTH2R (show PTH2R Proteins)(-/-) mice showed abnormal extracellular matrix structure, decreased decorin expression, and skin hardness.

  2. The disruption of decorin-restricted TGFbeta (show TGFB1 Proteins) signalling leads to higher stiffness of articular cartilage matrix, rendering joints more resistant to osteoarthritis.

  3. We could show that ablation of either candidate enhanced adipogenesis in visceral preadipocytes, while treatment of primary cultures with recombinant Sparcl1 and Dcn blocked adipogenesis in a dose dependent manner. In conclusion, our data suggests that the differences in adipogenesis between depots might be due to paracrine and autocrine feedback mechanisms which could in turn contribute to metabolic homeostasis

  4. A synthetic peptide corresponding to this decorin region dose-dependently inhibited the response to myostatin (show MSTN Proteins) in cardiomyocytes

  5. Systemic delivery of an oncolytic adenovirus expressing decorin for the treatment of breast cancer bone metastases reduced tumor burden and inhibited bone destruction.

  6. Decorin is an autophagy-inducible proteoglycan (show Vcan Proteins) and is required for proper in vivo autophagy.

  7. Importance of biglycan (show BGN Proteins) and decorin as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.

  8. The results suggest that decorin plays a dual role in AAA (show AAAS Proteins). Adventitial decorin in normal aorta may protect against the development of AAA (show AAAS Proteins)

  9. Development of congenital stromal dystrophy is dependent on export and extracellular deposition of truncated decorin.

  10. decorin may modulate follicular cycling and morphogenesis

Pig (Porcine) Decorin (DCN) interaction partners

  1. LDL electrostatic interactions with decorin and biglycan (show BGN Proteins) in the aortic valve leaflets and vascular wall is a major source of LDL retention.

  2. The expression of the DCN gene increased from gestational day 26 to 90 in both Yorkshire and Meishan pig placenta.

Decorin (DCN) Protein Profile

Protein Summary

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.

Alternative names and synonyms associated with Decorin (DCN)

  • decorin (DCN)
  • decorin (Dcn)
  • decorin (dcn)
  • cscd protein
  • DC protein
  • DCN protein
  • dspg2 protein
  • mDcn protein
  • pg40 protein
  • pgii protein
  • pgs2 protein
  • slrr1b protein

Protein level used designations for Decorin Proteins (DCN)

decorin , PG-S2 , bone proteoglycan II , decorin proteoglycan , dermatan sulphate proteoglycans II , proteoglycan core protein , small leucine-rich protein 1B , DSPG , PG40 , dermatan sulfate proteoglycan-II (decorin) , DS-PGII , dermatan sulfate proteoglycan II

100033862 Equus caballus
417892 Gallus gallus
1634 Homo sapiens
280760 Bos taurus
13179 Mus musculus
396957 Sus scrofa
100009171 Oryctolagus cuniculus
29139 Rattus norvegicus
403904 Canis lupus familiaris
447482 Xenopus laevis
100174912 Cavia porcellus
100034120 Equus caballus
443048 Ovis aries
100860944 Capra hircus
452120 Pan troglodytes
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