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HtrA Serine Peptidase 1 Proteins (HTRA1)
On www.antibodies-online.com are 20 HtrA Serine Peptidase 1 (HTRA1) Proteins from 7 different suppliers available. Additionally we are shipping HtrA Serine Peptidase 1 Antibodies (73) and HtrA Serine Peptidase 1 Kits (28) and many more products for this protein. A total of 126 HtrA Serine Peptidase 1 products are currently listed.
Synonyms:
AI429470, ARMD7, CARASIL, HTRA, HTRA1, L56, MGC145723, ORF480, Prss11, RSPP11, Xhtra1, zgc:92029, zgc:172061
list all proteins Gene Name GeneID UniProt
HTRA1 5654 Q92743
HTRA1 56213 Q9R118
HTRA1 65164 Q9QZK5

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HtrA Serine Peptidase 1 Proteins (HTRA1) by Origin

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Top referenced HtrA Serine Peptidase 1 Proteins

  1. Human HTRA1 Protein expressed in Escherichia coli (E. coli) - ABIN368668 : Frochaux, Hildebrand, Talke, Linscheid, Schlüter: Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. in PLoS ONE 2014 (PubMed)

More Proteins for HtrA Serine Peptidase 1 Interaction Partners

Zebrafish HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.

Rhesus Monkey HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.

  2. Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 (show ARMS2 Proteins) to be associated with drusen.

  3. As in humans, one variant within LOC387715/ARMS2 (show ARMS2 Proteins) and one in HTRA1 were significantly associated with age-related macular degeneration.

Human HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD (show AMD1 Proteins)) pathogenesis.

  2. Variants in HTRA1 are not associated with age-related macular degeneration.

  3. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers

  4. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation

  5. correlation between TGFb1 (show TGFB1 Proteins) and pSmad2 as well as between HtrA1 and TGFb1 (show TGFB1 Proteins) and the very significant increase of Ki67 (show MKI67 Proteins) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.

  6. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties.

  7. significant increase of serum HtrA1 in early-onset pre-eclampsia

  8. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 (show TGFB1 Proteins) expression, which may cause severe CARASIL and peripheral small arterial disease

  9. Human HTRA1 expression is enhanced by Age-related macular degeneration specific indel mutation in the promoter region of HTRA1 gene, and this enhanced HTRA1 may be concerned with induce retinal neovasucularization.

  10. Results does not conclusively support HTRA1 role as a tumor suppressor but suggest its possible prognostic role in many human tumors.

Mouse (Murine) HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. transfection of cells with a constitutively active rapamycin-resistant p70S6K (show RPS6KB1 Proteins) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.

  2. Increased expressions of Tgf-beta1 (show TGFB1 Proteins), p-Smad2 (show SMAD2 Proteins)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.

  3. In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (show TGFB1 Proteins) pathway activation.

  4. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone

  5. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (show AMD1 Proteins)

  6. the inhibitory effect of IFN-gamma (show IFNG Proteins) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (show NCOA5 Proteins)) mouse models and in human RA synovial cells.

  7. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

  8. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)/5/8, ERK1/2 and p38 (show CRK Proteins) phosphorylation in pre-osteoblasts.

  9. This study offers new insights into the regulation of HTRA-1 expression via LPS (show TLR4 Proteins)/TLR-4 (show TLR4 Proteins) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.

  10. suggest a critical role for LRP1 (show LRP1 Proteins) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (show CTGF Proteins) protein levels.

Xenopus laevis HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.

HtrA Serine Peptidase 1 (HTRA1) Protein Profile

Protein Summary

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Alternative names and synonyms associated with HtrA Serine Peptidase 1 (HTRA1)

  • HtrA serine peptidase 1a (htra1a)
  • HtrA serine peptidase 1 (HTRA1)
  • HtrA serine peptidase 1b (htra1b)
  • HtrA serine peptidase 1 (htra1)
  • Serine protease HTRA1 (htra1)
  • HtrA serine peptidase 1 (Htra1)
  • serine protease (HTRA)
  • AI429470 protein
  • ARMD7 protein
  • CARASIL protein
  • HTRA protein
  • HTRA1 protein
  • L56 protein
  • MGC145723 protein
  • ORF480 protein
  • Prss11 protein
  • RSPP11 protein
  • Xhtra1 protein
  • zgc:92029 protein
  • zgc:172061 protein

Protein level used designations for HTRA1

HtrA serine peptidase 1 , high-temperature requirement A serine peptidase 1A , serine protease 11 , serine protease HTRA1A , high-temperature requirement A serine peptidase 1B , serine protease HTRA1B , high temperature required A1 , Serine protease HTRA1 , IGFBP5-protease , high-temperature requirement A serine peptidase 1 , protease, serine, 11 (IGF binding) , serine protease HTRA1 , insulin-like growth factor binding protein 5 protease , protease, serine, 11 (Igf binding) , IGF binding , protease, serine, 11 , protease serine 11 , High-temperature requirement A serine peptidase 1 , Serine protease 11

GENE ID SPECIES
431766 Danio rerio
450792 Pan troglodytes
565082 Danio rerio
705855 Macaca mulatta
780187 Xenopus (Silurana) tropicalis
100064570 Equus caballus
100196695 Salmo salar
100541363 Meleagris gallopavo
100564246 Anolis carolinensis
100583976 Nomascus leucogenys
5654 Homo sapiens
56213 Mus musculus
477852 Canis lupus familiaris
282326 Bos taurus
65164 Rattus norvegicus
496061 Xenopus laevis
100857572 Gallus gallus
100008705 Oryctolagus cuniculus
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