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The phosphorylation of p53 (show TP53 Proteins) by CK1 (show CSNK1A1 Proteins) is an isoform-specific reaction to the K(221)RQK(224) loop.
Our results reveal a new mechanism of ZNF322A (show ZNF322A Proteins) oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A (show ZNF322A Proteins) overexpression and promotes cancer progression
Report temperature-compensated CKIdelta-dependent multi-site phosphorylation in mammals underlies temperature compensated phosphorylation in circadian clocks.
Study describes a specific mechanism for the regulation of CK1delta activity by proline-directed kinases, and demonstrate the relevance of this regulation in the control of a key CK1delta substrate, the PER2 (show PER2 Proteins) protein.
Protein kinase C alpha (PKCalpha (show PKCa Proteins)) is able to phosphorylate CK1delta at its C-terminally located residues S328, T329, and S370.
the results suggest that CK1delta activity can be modulated by the interplay between CK1delta and CDK2 (show CDK2 Proteins)/E or CDK5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins).
CK1delta inhibition represents a promising strategy for targeted treatment in human breast cancer with Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) involvement.
Expression of truncated hyperactive form of CKIdelta causes mislocalization and aggregation of TDP-43 (show TARDBP Proteins) in cultured cells.
Inhibition of CK1delta increases lipid droplet formation and proliferation of both cancer and normal cells specifically under hypoxia and in an HIF-1alpha (show HIF1A Proteins)- and lipin-1 (show LPIN1 Proteins)-dependent manner.
site-specific phosphorylation of adiponectin (show ADIPOQ Proteins), especially at sites targeted by CK1delta in vitro, provides an additional regulatory mechanism for modulating adiponectin (show ADIPOQ Proteins) complex formation and function.
The dynamical and conformational properties for each of three isoforms of CK1 (show CSNK1A1L Proteins) are explored through molecular dynamics (MD) simulations.
Here, the authors identify another Wnt (show WNT2 Proteins) signaling amplifier, CKIepsilon (show CSNK1E Proteins), which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta.
Together, these findings suggest that CK1delta contributes to the efficient repair of DNA damage and the proper functioning of mitotic checkpoints by maintaining appropriate levels of Chk1 (show CHEK1 Proteins).
we conclude that APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins)) controls CK1 delta levels to balance proliferation and cell-cycle exit in the developing CNS
CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi.
this article reports the crystallization and structure determination of a new crystal form of casein kinase I delta belonging to space group P21.
decreases in CKIdelta activity can contribute to the pathogenesis of migraine.
REGgamma (show PSME3 Proteins)-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK)1delta and p53 (show TP53 Proteins). Antibody array analysis identified CK1delta as a direct target of REGgamma (show PSME3 Proteins).
CK1delta plays a more prominent role than CK1epsilon (show CSNK1E Proteins) in the maintenance of 24-hour rhythms in the master circadian oscillator
These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a (show WNT3A Proteins)-dependent neuritogenesis.
The results demonstrate a high degree of evolutionary conservation of fly and vertebrate CKIdelta and of the functions affected by their period-shortening mutations.
This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.
casein kinase I-delta
, casein kinase I isoform delta
, casein kinase I isoform delta-B
, casein kinase 1, delta
, casein kinase I, delta
, casein kinase I isoform delta-like
, tau-protein kinase CSNK1D
, casein kinase I delta
, protein kinase