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Browse our Patched 1 Proteins (PTCH1)

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Patched 1 Proteins (PTCH1)
On are 18 Patched 1 (PTCH1) Proteins from 6 different suppliers available. Additionally we are shipping Patched 1 Antibodies (147) and Patched 1 Kits (4) and many more products for this protein. A total of 181 Patched 1 products are currently listed.
A230106A15Rik, BCNS, HPE7, lep, mes, NBCCS, patched, patched1, Ptc, Ptc-1, Ptc1, ptc2, Ptch, ptch1, Ptch2, PTCH11, XPtc1
list all proteins Gene Name GeneID UniProt
PTCH1 5727 Q13635
Rat PTCH1 PTCH1 89830  
PTCH1 19206 Q61115

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Patched 1 Proteins (PTCH1) by Origin

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More Proteins for Patched 1 Interaction Partners

Zebrafish Patched 1 (PTCH1) interaction partners

  1. Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2 (show PTCH2 Proteins)-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2 (show PTCH2 Proteins)-/- mutants.

  2. The Hedgehog (show SHH Proteins) co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.

  3. The generation and characterization of the ptc1;ptc2 (show PTCH2 Proteins) double mutant assigned novel and unexpected functions to the Hh signaling pathway.

  4. Positional cloning of blowout identified a nonsense mutation in patched1, a negative regulator of the Hedgehog (show SHH Proteins) pathway, as the underlying cause of the blowout phenotype.

Human Patched 1 (PTCH1) interaction partners

  1. Increased SHH (show SHH Proteins), PTCH, and GLI1 (show GLI1 Proteins) protein correlated positively with tumor grade, tumor depth and lymph node metastasis in Peutz-Jeghers syndrome.

  2. The results do not support our hypothesis that common germline genetic variants in the PTCH1 genes is associated with the risk of developing medulloblastoma.

  3. after 20 years of the molecular and epidemiological research of RET/PTC (show RET Proteins) in thyroid radiogenic carcinomas the comprehensive evidence of the dose-effect dependence existence indicating a real relationship between the studied parameters and radiation factor

  4. A genome-wide association study of bone mineral density (BMD (show BEST1 Proteins)) found a new BMD (show BEST1 Proteins) locus that harbors the PTCH1 gene, that associates with reduced spine BMD (show BEST1 Proteins) and the RSPO3 (show RSPO3 Proteins) associates with increased spine BMD (show BEST1 Proteins).

  5. The Cytoskeletal Protein (show ACTN1 Proteins) Zyxin (show ZYX Proteins) Interacts with the Hedgehog (show SHH Proteins) Receptor Patched

  6. results indicate that whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation

  7. Frequent inactivating PTCH1 mutations were found in oesophageal basaloid squamous cell carcinoma. These changes activate the Hedgehog (show SHH Proteins) pathway, which has been shown to cross-talk with the Wnt (show WNT2 Proteins) signalling pathway.

  8. Melittin induces PTCH1 expression by down-regulating MeCP2 (show MECP2 Proteins) and blocking Shh (show SHH Proteins) signaling in human hepatocellular carcinoma cells.

  9. PTCH1 expression is regulated by different 5' untranslated region cis (show CISH Proteins)-regulatory elements.

  10. Data indicate microRNA-9 (miR (show MLXIP Proteins)-9) as the target of patched protein 1 (PTCH1) in resistant glioblastoma multiforme (GBM) cells with concomitant activation of sonic hedgehog SHH (show SHH Proteins) signaling.

Cow (Bovine) Patched 1 (PTCH1) interaction partners

  1. study suggests that modifications affecting the Ptch1 cis (show CISH Proteins)-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs

Mouse (Murine) Patched 1 (PTCH1) interaction partners

  1. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins).

  2. Data show that the ketogenic diet does not affect growth of Ptch1+/-Trp53 (show TP53 Proteins)-/- Hedgehog (show SHH Proteins) (HH) pathway medulloblastoma.

  3. Targeted single gene deletion of Ptch1 in mouse brain causes medulloblastoma.

  4. Transcriptional upregulation of the inhibitory receptor Ptch1 regulates Shh (show SHH Proteins) signaling during neural tube development.

  5. There was a lower degree of DNA-methylation (show HELLS Proteins) in methylation-sensitive CpG regions of the Ptch promoter in RMS compared to normal muscle from heterozygous Ptch animals.

  6. results indicate that whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation

  7. Dsg2 (show DSG2 Proteins)-mediated hyperproliferation, MEK (show MDK Proteins)/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1+/lacZ (show GLB1 Proteins) background.

  8. Data show that the Hedgehog (Hh) pathway activation by either a ligand or genetic loss of the negatively acting Hh receptor Patched-1 (Ptch) reduced the affinity and frequency of signaling protein Smoothened (Smo) binding at the base.

  9. Shh (show SHH Proteins) and transforming growth factor beta signaling cooperate to promote Ptch1-associated cataract development by activating EMT (show ITK Proteins)

  10. Smurf-mediated endocytosis of Patched1 is required in sonic hedgehog (show SHH Proteins) signal reception

Patched 1 (PTCH1) Protein Profile

Protein Summary

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Alternative names and synonyms associated with Patched 1 (PTCH1)

  • patched 2 (ptch2)
  • patched 1 (PTCH1)
  • patched protein-like protein (PTCH1)
  • patched 1 (ptch1)
  • patched 1 (Ptch1)
  • patched homolog 1 (Ptch1)
  • Protein PTC-1 (ptc-1)
  • A230106A15Rik protein
  • BCNS protein
  • HPE7 protein
  • lep protein
  • mes protein
  • NBCCS protein
  • patched protein
  • patched1 protein
  • Ptc protein
  • Ptc-1 protein
  • Ptc1 protein
  • ptc2 protein
  • Ptch protein
  • ptch1 protein
  • Ptch2 protein
  • PTCH11 protein
  • XPtc1 protein

Protein level used designations for Patched 1 Proteins (PTCH1)

blowout , blw , etID309849.2 , patched 1 , protein patched homolog 1 , patched homolog 1 , patched protein-like protein , patched-like , protein patched homolog 1-like , PTC1 , patched protein , patched-like protein , PTCH protein +12b , PTCH protein +4' , PTCH protein -10 , PTCH protein -3,4,5 , patched homolog 2 , leprechaun , patched 2 , patched-1 , Patched 1 , Ptch1 protein +12b , mesenchymal dysplasia

30181 Danio rerio
465254 Pan troglodytes
718751 Macaca mulatta
7230532 Branchiostoma floridae
100033936 Equus caballus
100345046 Oryctolagus cuniculus
100475966 Ailuropoda melanoleuca
100492061 Xenopus (Silurana) tropicalis
100581789 Nomascus leucogenys
395806 Gallus gallus
5727 Homo sapiens
89830 Rattus norvegicus
30189 Danio rerio
484137 Canis lupus familiaris
100627504 Sus scrofa
520994 Bos taurus
398215 Xenopus laevis
19206 Mus musculus
174274 Caenorhabditis elegans
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