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Browse our Claudin 2 Proteins (CLDN2)

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Claudin 2 Proteins (CLDN2)
On are 6 Claudin 2 (CLDN2) Proteins from 3 different suppliers available. Additionally we are shipping Claudin 2 Antibodies (160) and Claudin 2 Kits (29) and many more products for this protein. A total of 203 Claudin 2 products are currently listed.
AL022813, CLDN2, RGD1560247, zgc:92260
list all proteins Gene Name GeneID UniProt
CLDN2 9075 P57739
CLDN2 12738 O88552
Rat CLDN2 CLDN2 300920  

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Claudin 2 Proteins (CLDN2) by Origin

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Top referenced Claudin 2 Proteins

  1. Human CLDN2 Protein expressed in Wheat germ - ABIN1349607 : Lim, Vedula, Hui, Kausalya, Hunziker, Lim: Probing effects of pH change on dynamic response of Claudin-2 mediated adhesion using single molecule force spectroscopy. in Experimental cell research 2008 (PubMed)
    Show all 2 references for ABIN1349607

More Proteins for Claudin 2 Interaction Partners

Human Claudin 2 (CLDN2) interaction partners

  1. hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 (show CLDN7 Proteins) and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells.

  2. The claudin-2 expression increased in tumor necrosis factor alpha (TNF-alpha (show TNF Proteins)) Treated Caco-2 cell monolayers.

  3. We conclude that Claudin-2 expression is significantly associated with bile acid receptors VDR (show CYP27B1 Proteins) and TGR5 (show GPBAR1 Proteins) expression. Our studies identify a novel role of a tight junction protein (show OCLN Proteins) in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.

  4. The authors conclude that claudin-2 forms gated paracellular channels.

  5. Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients.

  6. The current study reveals an important and novel mechanism for VDR (show CYP27B1 Proteins) by regulation of epithelial barriers.

  7. Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 (show GDE1 Proteins) expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.

  8. Pan-inhibition of SFK signaling pathways elevated Claudin-2 expression levels in breast cancer cells. Loss of Yes or Fyn (show FYN Proteins) induces Claudin-2 expression; whereas, diminished Lyn (show LYN Proteins) levels impairs Claudin-2 expression in breast cancer cells.

  9. PKCiota binds to Rab14 (show RAB14 Proteins) and that PKCiota requires Rab14 (show RAB14 Proteins) for its correct distribution in cells. As with Rab14 (show RAB14 Proteins), PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier.

  10. Phosphorylation state of the tyrosine of claudin-1 (show CLDN7 Proteins) and claudin-2 regulates interaction with ZO1 (show TJP1 Proteins).

Mouse (Murine) Claudin 2 (CLDN2) interaction partners

  1. The current study reveals an important and novel mechanism for VDR (show CYP27B1 Proteins) by regulation of epithelial barriers.

  2. findings reveal a critical albeit complex role of claudin-2 in intestinal homeostasis by regulating epithelial permeability, inflammation and proliferation

  3. Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.

  4. IL-6 (show IL6 Proteins) modulation of intestinal TJ permeability was regulated by JNK (show MAPK8 Proteins) activation of AP-1 (show JUN Proteins) and AP-1 (show JUN Proteins) activation of claudin-2 gene

  5. this study set out to map out all the pore-lining residues of claudin-2 by comprehensive cysteine-scanning mutagenesis of the entire first extracellular loop (ECL1).

  6. The capacity of non-AQP1 (show AQP1 Proteins)-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1 (show AQP1 Proteins)- and claudin-2-doubly deficient knockout mice.

  7. These results suggest that the ERK (show EPHB2 Proteins) pathway positively regulates claudin-2 protein expression and claudin-2 is involved in lowering TER (show TECR Proteins) in CMT93-II cells.

  8. Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK (show MYLK Proteins) in colon inflammation.

  9. cingulin is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2.

  10. Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane

Claudin 2 (CLDN2) Protein Profile

Protein Summary

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

Alternative names and synonyms associated with Claudin 2 (CLDN2)

  • claudin 2 (CLDN2)
  • claudin 2 (cldn2)
  • claudin 2 (Cldn2)
  • AL022813 protein
  • CLDN2 protein
  • RGD1560247 protein
  • zgc:92260 protein

Protein level used designations for Claudin 2 Proteins (CLDN2)

claudin 2 , SP82 , claudin-2 , integral membrane protein claudin-2

465795 Pan troglodytes
562525 Danio rerio
9075 Homo sapiens
12738 Mus musculus
422292 Gallus gallus
403649 Canis lupus familiaris
733684 Sus scrofa
404089 Bos taurus
300920 Rattus norvegicus
780475 Ovis aries
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