Browse our LDLR Proteins (LDLR)

Full name:
Low Density Lipoprotein Receptor Proteins (LDLR)
On are 39 Low Density Lipoprotein Receptor (LDLR) Proteins from 11 different suppliers available. Additionally we are shipping LDLR Antibodies (281) and LDLR Kits (50) and many more products for this protein. A total of 378 LDLR products are currently listed.
list all proteins Gene Name GeneID UniProt
LDLR 3949 P01130
LDLR 16835 P35951
LDLR 300438 P35952

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LDLR Proteins (LDLR) by Origin

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Top referenced LDLR Proteins

  1. Mouse (Murine) LDLR Protein expressed in Human Cells - ABIN2007638 : Südhof, Goldstein, Brown, Russell: The LDL receptor gene: a mosaic of exons shared with different proteins. in Science (New York, N.Y.) 1985 (PubMed)
    Show all 4 references for 2007638

  2. Mouse (Murine) LDLR Protein expressed in HEK-293 - ABIN2666847 : Bieghs, Van Gorp, Wouters, Hendrikx, Gijbels, van Bilsen, Bakker, Binder, Lütjohann, Staels, Hofker, Shiri-Sverdlov: LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. in PLoS ONE 2012 (PubMed)
    Show all 4 references for 2666847

  3. Human LDLR Protein expressed in HEK-293 - ABIN2666986 : Brown, Goldstein: How LDL receptors influence cholesterol and atherosclerosis. in Scientific American 1985 (PubMed)
    Show all 4 references for 2666986

  4. Human LDLR Protein expressed in HEK-293 Cells - ABIN2181455 : Nomura, Merched, Nour, Dieker, Oka, Chan: Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. in Gene therapy 2004 (PubMed)

More Proteins for LDLR Interaction Partners

Human Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. PCSK9 (show PCSK9 Proteins) inhibits lipoprotein(a) clearance through the LDLR.

  2. 4 siblings found to be compound heterozygotes for 2 LDLR gene mutations but showing a different phenotype severity

  3. LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs

  4. Higher Gleason grade was associated with lower LDLR expression, lower SOAT1 (show SOAT1 Proteins) and higher SQLE (show SQLE Proteins) expression. Besides high SQLE (show SQLE Proteins) expression, cancers that became lethal despite primary treatment were characterized by low LDLR expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (show SOAT1 Proteins) expression (odds ratio, 0.41; 95% CI 0.21-0.83).

  5. LDLR associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age /=160 mg/dl.

  6. Chinese W483X mutation in the low-density lipoprotein-receptor gene in young patients with homozygous familial hypercholesterolemia

  7. Proprotein convertase subtilisin (show PCSK9 Proteins)/kexin 9 V4I variant with LDLR mutations modifies the phenotype of familial hypercholesterolemia

  8. both LDLR rs6511720 and rs57217136 are functional variants; both these minor alleles create enhancer-binding protein sites for transcription factors and may contribute to increased LDLR expression, which is consequently associated with reduced LDL-C levels and 12% lower coronary heart disease risk

  9. Using assays that measured conformational change, acid-dependent lipoprotein release, LDLR recycling, and net lipoprotein uptake, we show that H635 plays important roles in acid-dependent conformational change and lipoprotein release, while H264, H306, and H439 play ancillary roles in the response of the LDLR to acidic pH

  10. these studies support that reductions in Lp(a (show APOA Proteins)) with PCSK9 (show PCSK9 Proteins) inhibition are partly due to increased LDLR-mediated uptake. In most situations, Lp(a (show APOA Proteins)) appears to compete poorly with LDL for LDLR binding and internalization, but when LDLR expression is increased with evolocumab, particularly in the setting of low circulating LDL, Lp(a (show APOA Proteins)) is reduced.

Cow (Bovine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE (show APOE Proteins), MTP (show MTTP Proteins), and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

Mouse (Murine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. CD11b (show ITGAM Proteins)+Gr-1 (show GSR Proteins)+ myeloid-derived suppressor cells suppress T cells in an IFN-gamma (show IFNG Proteins)- and nitric oxide-dependent manner to reduce atherosclerotic lesion development in LDLr deficient mice.

  2. This study investigated the effects of Aerobic exercise training on endothelial dysfunction and vascular redox status in the aortas of LDL receptor knockout mice (LDLr(-/-)), a genetic model of familial hypercholesterolemia.

  3. PCSK9 (show PCSK9 Proteins) inhibits lipoprotein(a) clearance through the LDLR.

  4. PTP1B (show PTPN1 Proteins) inhibitors protect against atherosclerotic plaque formation in the LDLR(-/-) mouse model of atherosclerosis.

  5. LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs

  6. ApoC-III (show APOC3 Proteins) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 (show LRP1 Proteins) axis

  7. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo

  8. This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor knockout mice.

  9. hepatocytes clear lipopolysaccharides from the circulation via the LDLR.

  10. Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor

Pig (Porcine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. The LDLR gene should be a candidate causative gene for LDL-cholesterol and total cholesterol in pigs, but heterogeneity exists in different populations.

  2. KLF13 (show KLF13 Proteins) and SREBP-Sp1 (show SP1 Proteins) activation interact to regulate low density lipoprotein receptor promoter function

  3. found association between genotypes for LDLR and APOB (show APOB Proteins) polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms

LDLR Protein Profile

Protein Summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with LDLR

  • low density lipoprotein receptor (ldlr)
  • low density lipoprotein receptor (LDLR)
  • low density lipoprotein receptor (Ldlr)
  • low density protein receptor (LOC443535)
  • FH protein
  • FHC protein
  • Hlb301 protein
  • LDLA protein
  • LDLCQ2 protein
  • LDLRA protein

Protein level used designations for LDLR

low-density lipoprotein receptor , LDL receptor , low-density lipoprotein receptor class A domain-containing protein 3 , low density lipoprotein receptor (familial hypercholesterolemia)

387529 Danio rerio
3949 Homo sapiens
281276 Bos taurus
100009086 Oryctolagus cuniculus
16835 Mus musculus
300438 Rattus norvegicus
100724238 Cavia porcellus
396801 Sus scrofa
100683160 Canis lupus familiaris
395103 Gallus gallus
100689399 Cricetulus griseus
443535 Ovis aries
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