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This report is the first to indicate lowered concentrations of calcitonin gene-related peptide (CGRP) as part of the metabolic changes during milk fever in cows.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
The reciprocal changes in SST (show SST Proteins) and histamine secretion in gastric Helicobacter infection were due to release of CGRP from sensory neurons.
Substance P (show TAC1 Proteins) and CGRP correlate with the occurrence and development of allergic rhinitis.
Preoperative calcitonin levels were correlated with the presence of tumor, whereas alkaline phosphatase (ALP) levels were not. There were no significant associations between tumor volume and ALP (show ALP Proteins) or calcitonin levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP (show ALP Proteins) was significantly associated with tumor recurrence, but serum calcitonin was not.
PCT (show UROD Proteins) median values were significantly higher in patients with sepsis than without during the first 10 postoperative days after cardiac surgery.
Point-of-care procalcitonin test can be used to substantially reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD (show ARCN1 Proteins).
Data suggest CGRP (show S100A12 Proteins) receptor (CGRPR (show CALCRL Proteins)) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP (show S100A12 Proteins); this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP (show S100A12 Proteins)/CGRPR (show CALCRL Proteins) interaction; CGRPR (show CALCRL Proteins) is obligate heterodimer of CLR (show DCLK3 Proteins)/RAMP1 (show RAMP1 Proteins). (CGRP (show S100A12 Proteins) = calcitonin gene-related peptide; CLR (show DCLK3 Proteins) = calcitonin receptor-like receptor (show CALCRL Proteins); RAMP1 (show RAMP1 Proteins) = receptor [calcitonin] activity modifying protein 1)
Elevated Expression of PCT (show UROD Proteins) is associated with Sepsis.
Both procalcitonin levels and white blood cell counts were significantly higher in patients with postoperative intraabdominal infections (IAIs) than those in patients without IAIs on postoperative day (POD) 1 (show TCF21 Proteins), POD 3, and POD 5, whereas C-reactive protein (show CRP Proteins) levels differed significantly on POD 3 and POD 5.
In mammalian neuromuscular junctions, different isoforms of exogenously applied calcitonin gene-related peptide uniformly potentiate amplitudes of evoked and spontaneous postsynaptic potentials acting presynaptically via an increase in acetylcholine quantal size.
Mouse and human heart valves expressed mRNAs for the CRL (show IL31RA Proteins) ligands adrenomedullin (show ADM Proteins) (AM), adrenomedullin-2 (AM-2 (show ADM2 Proteins)) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL (show IL31RA Proteins) and receptor-activity-modifying proteins 1-3.
Procalcitonin has no superiority over C-reactive protein (show CRP Proteins) in diagnosis of community-acquired pneumonia in patients with end stage renal failure.
Higher levels of PCT (show UROD Proteins), a marker of infection, and MRproANP, a marker for hemodynamic stress, were independently associated with ischemic stroke risk. PCT (show UROD Proteins) was specifically associated with small vessel and MRproANP with cardioembolic stroke risk.
High level of co-expression of PACAP (show ADCYAP1 Proteins) with VIP (show Vip Proteins), SP and CGRP in the distal ganglia of the vagus sensory perikarya directly implicates studied peptides in their functional interaction during nociceptive vagal transduction.
This study demonstrated for the first time a strong expression of NGF, TrkA, CGRP, nNOS and neuronal specific enolase in the majority of esophageal enteric nervous system components.
Localization of calcitonin gene related peptide in the nerve fibers of porcine cystic ovaries
Calcitonin is a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase (show CYP27B1 Proteins) gene.
CGRP-antibodies can be used as markers for type II neurons in the pig small intestinal myenteric plexus in quantitative studies but it should be kept in mind that up to one-tenth of CGRP-reactive neurons may be non-type II neurons.
The data provide morphological evidence confirming expression of CGRP in the porcine spinal nuclei while its coexpression in cholinergic neurons suggests that CGRP may play a role in modulation of the spinal cholinergic transmission.
results indicate that CGRP regulates macrophage polarization and inhibits inflammation in murine macrophages.
In addition to its actions in the cardiovascular system, endogenous CGRP is a key regulator of metabolism and energy homeostasis in vivo.
findings establish CGRP neurons in the parabrachial nucleus as key mediators of cancer-induced appetite suppression and associated behavioral changes.
These results identify an important, possibly dual role of CGRP in Amyotrophic lateral sclerosis pathogenesis.
functional inactivation of CGRP neurons markedly increases meal size, with meal frequency being reduced in a compensatory manner, and renders mice insensitive to the anorexic effects of meal-related satiety peptides.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (show ADM Proteins) (AM), adrenomedullin-2 (AM-2 (show ADM2 Proteins)) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
The abundance of mRNA of CGRP and bone matrix markers (Col (show HDAC1 Proteins) I, Col (show HDAC1 Proteins) II, and OPN (show SPP1 Proteins)) was low at P5 in the tibia. These differences in CGRP and other mRNAs may induce a different manner of ossification between the mandible and tibia. Therefore, a time lag (show STMN1 Proteins) of ossification occurs between the mandible and tibia during foetal development.
Suggest that cochlear function is enhanced by maturation of CGRP receptor complexes.
the generation of Tregs may be promoted by naive CD4 (show CD4 Proteins)+ T cell: neuron interaction through the release of neuropeptide CGRP.
The observations of this study imply that Adelta afferents expressing CGRP-IR transduce information from different sites within the skin.
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
calcitonin gene-related peptide 2
, calcitonin-related polypeptide 3
, calcitonin-related polypeptide alpha
, calcitonin/calcitonin-related polypeptide, alpha
, Calcitonin gene-related peptide
, calcitonin gene-related peptide
, alpha-type CGRP
, calcitonin 1
, calcitonin gene-related peptide I
, calcitonin gene-related peptide 1
, calcitonin gene related peptide I
, calcitonin-related polypeptide, beta
, alpha CGRP
, calcitonin/alpha CGRP