Browse our DIO3 Proteins (DIO3)

Full name:
Deiodinase, Iodothyronine, Type III Proteins (DIO3)
On are 15 Deiodinase, Iodothyronine, Type III (DIO3) Proteins from 5 different suppliers available. Additionally we are shipping DIO3 Antibodies (95) and DIO3 Kits (22) and many more products for this protein. A total of 136 DIO3 products are currently listed.
5DIII, D3, dioiii, itdi3, TXDI3, XL-15
list all proteins Gene Name GeneID UniProt
DIO3 107585 Q91ZI8
DIO3 29475 P49897
DIO3 1735 P55073

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DIO3 Proteins (DIO3) by Origin

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More Proteins for DIO3 Interaction Partners

Mouse (Murine) Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

  1. Dio3-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2 (show DIO2 Proteins)-/- mice, cone function was largely normal but deletion of Dio2 (show DIO2 Proteins) in Dio3-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.

  2. The marked phenotypic abnormalities observed in the D3-deficient mouse, including perinatal mortality, growth retardation, and central hypothyroidism in adult animals, require expression of MCT8 (show MCT8 Proteins), confirming the interdependent relationship between the TH transport into cells and the deiodination processes.

  3. The brain-specific (show CALY Proteins) miR (show MLXIP Proteins)-379/miR (show MLXIP Proteins)-410 gene cluster at the imprinted Dlk1 (show DLK1 Proteins)-Dio3 domain is implicated in several aspects of brain development and function.

  4. DNA methylation (show HELLS Proteins) regulates genomic imprinted DLK1 (show DLK1 Proteins)-Dio3 miRNAs in autoimmune lupus

  5. identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1 (show DLK1 Proteins)-Dio3 locus

  6. Dppa3 (show DPPA3 Proteins) has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Proteins) cells and maintenance of Dlk1 (show DLK1 Proteins)-Dio3 imprinting

  7. Gtl2((-/+)) teratomas have decreased expression of 28 miRNAs encoded by the Dlk1 (show DLK1 Proteins)-Dio3 domain

  8. This study provides the spatiotemporal expression and dynamic changes of lncRNAs from Dlk1-Dio3 imprinted region in mouse preimplantation stage embryos and offers insight into the potential mechanisms responsible for Gtl2 activation.

  9. The existence of unidentified epigenetic determinants of tissue-specific Dio3 imprinting.

  10. DNA methylation (show HELLS Proteins) dynamics of a maternally methylated DMR (show WDR20 Proteins) in the mouse Dlk1 (show DLK1 Proteins)-Dio3 domain

Xenopus laevis Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

  1. No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.

Human Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

  1. In neonatal skin, DIO3 exhibited a high degree of monoallelic expression from the paternal allele.

  2. Presence and subcellular location of D3 in human neutrophils for the first time and propose a model, in which D3 plays a role in the bacterial killing capacity of neutrophils either through generation of iodide for the myeloperoxidase (show MPO Proteins) system or through modulation of intracellular Thyroid hormone (show PTH Proteins) bioavailability.

  3. MAPK (show MAPK1 Proteins) and SHH (show SHH Proteins) pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma

  4. Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.

  5. the microRNA cluster at the Dlk1 (show DLK1 Proteins)-Dio3 locus is upregulated in lung adenocarcinoma

  6. [review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone (show PTH Proteins) parameters.

  7. Overall, the data suggest that active expression of the DLK1 (show DLK1 Proteins)-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.

  8. the imprinted DLK1 (show DLK1 Proteins)-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome

  9. Data indicate that Na+/I- symporter and type 3 iodothyronine deiodinase genes are expressed in term placenta and amniotic membrane.

  10. Reviewed are the microRNAs within the DLK1 (show DLK1 Proteins)-DIO3 genomic region, their role in controlling tissue homeostasis and in the pathogenesis of some human diseases, mostly cancer, when aberrantly expressed. [review]

Pig (Porcine) Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

  1. The imprinted gene DIO3 is a candidate gene for litter size in pigs

  2. DIO3 gene polymorphism was significantly associated with almost all fat deposition and carcass traits.

DIO3 Protein Profile

Protein Summary

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Alternative names and synonyms associated with DIO3

  • deiodinase, iodothyronine, type III (DIO3)
  • deiodinase, iodothyronine, type 3 (dio3)
  • deiodinase, iodothyronine, type III (dio3)
  • deiodinase, iodothyronine type III (Dio3)
  • deiodinase, iodothyronine, type III (Dio3)
  • 5DIII protein
  • D3 protein
  • dioiii protein
  • itdi3 protein
  • TXDI3 protein
  • XL-15 protein

Protein level used designations for DIO3

type III iodothyronine deiodinase , Type 3 DI , Type-III 5'-deiodinase , type 3 iodothyronine deiodinase , deiodinase, iodothyronine, type III , gene 15 , type 3 deiodinase , iodothyronine 5-deiodinase type III , 5DIII , DIOIII , type 3 DI , type-III 5'-deiodinase , deiodinase, iodothyronine, type 3 , iodothyronine deiodinase, placental type , thyroxine deiodinase type III (selenoprotein) , type 3 iodothyronine selenodeiodinase , type-III 5' deiodinase , iodothyronine deiodinase type III

100142657 Ovis aries
467559 Pan troglodytes
708027 Macaca mulatta
100038242 Xenopus (Silurana) tropicalis
100146344 Equus caballus
100150010 Danio rerio
107585 Mus musculus
397779 Xenopus laevis
29475 Rattus norvegicus
1735 Homo sapiens
100357267 Oryctolagus cuniculus
612596 Canis lupus familiaris
414378 Sus scrofa
494549 Bos taurus
395939 Gallus gallus
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