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DIO3 Products

(Deiodinase, Iodothyronine, Type III (DIO3))
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008].

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Featured DIO3 Categories

DIO3 Antibodies

High quality antibodies with extensive validation data.

DIO3 ELISA Kits

Reliable ELISA kits for a wide range of species.

DIO3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DIO3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN750883
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC (p), WB
Validations
  • (2)
Cat. No. ABIN5532317
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN2158553
Quantity 400 μL
Datasheet Datasheet

Recommended DIO3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966308
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966309
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955331
Quantity 96 tests
Datasheet Datasheet

Recommended DIO3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3127567
Quantity 0.25 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3081961
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3127568
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our DIO3 products

Calonne, Isacco, Miles-Chan, Arsenijevic, Montani, Guillet, Boirie, Dulloo: "Reduced Skeletal Muscle Protein Turnover and Thyroid Hormone Metabolism in Adaptive Thermogenesis That Facilitates Body Fat Recovery During Weight Regain." in: Frontiers in endocrinology, Vol. 10, pp. 119, (2019) (PubMed).

Benedetti, Lavecchia, Locatelli, Brizi, Corna, Todeschini, Novelli, Benigni, Zoja, Remuzzi, Xinaris: "Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes." in: JCI insight, Vol. 4, Issue 18, (2019) (PubMed).

Pörings, Lowin, Dufner, Grifka, Straub: "A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients." in: Scientific reports, Vol. 9, Issue 1, pp. 13235, (2019) (PubMed).

Yamauchi, Sakane, Yamashita, Hirota, Ueda, Kanai, Yamashita, Kondo, Fujii, Taura, Sone, Yasoda, Inagaki: "Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans." in: Endocrine, Vol. 59, Issue 2, pp. 353-363, (2018) (PubMed).

De Andrade, Neff, Strosova, Arsenijevic, Patthey-Vuadens, Scapozza, Montani, Ruegg, Dulloo, Dorchies: "Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding." in: Frontiers in physiology, Vol. 6, pp. 254, (2015) (PubMed).

Maynard, Marino-Enriquez, Fletcher, Dorfman, Raut, Yassa, Guo, Wang, Dorfman, Feldman, Frates, Song, Jugo, Taguchi, Hershman, Larsen, Huang: "Thyroid hormone inactivation in gastrointestinal stromal tumors." in: The New England journal of medicine, Vol. 370, Issue 14, pp. 1327-34, (2014) (PubMed).

Medina, Fonesca, Molina, Fachado, Castillo, Dong, Soares, Hernández, Caicedo, Bianco: "Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis." in: Endocrinology, Vol. 155, Issue 8, pp. 3160-71, (2014) (PubMed).

Castroneves, Jugo, Maynard, Lee, Wassner, Dorfman, Bronson, Ukomadu, Agoston, Ding, Luongo, Guo, Song, Demchev, Lee, Feldman, Vella, Peake, Hartigan, Kellogg, Desai, Salvatore, Dentice, Huang: "Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis." in: Endocrinology, Vol. 155, Issue 10, pp. 4061-8, (2014) (PubMed).

Dudek, Suter, Darras, Marczylo, Gant: "Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity." in: The Biochemical journal, Vol. 453, Issue 1, pp. 71-82, (2013) (PubMed).

Vose, Vinukonda, Jo, Miry, Diamond, Korumilli, Arshad, Zia, Hu, Kayton, La Gamma, Bansal, Bianco, Ballabh: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).

Synonyms and alternative names related to DIO3

iodothyronine deiodinase 3 (DIO3), deiodinase, iodothyronine, type 3 (dio3), deiodinase, iodothyronine, type III (dio3), deiodinase, iodothyronine type III (Dio3), deiodinase, iodothyronine, type 3 L homeolog (dio3.L), iodothyronine deiodinase 3 (Dio3), 5DIII, D3, DIOIII, dioiii, itdi3, txdi3, TXDI3, XL-15

Protein level used designations for DIO3

  • type III iodothyronine deiodinase
  • Type 3 DI
  • Type-III 5'-deiodinase
  • type 3 iodothyronine deiodinase
  • deiodinase, iodothyronine, type III
  • gene 15
  • type 3 deiodinase
  • iodothyronine 5-deiodinase type III
  • 5DIII
  • DIOIII
  • type 3 DI
  • type-III 5'-deiodinase
  • deiodinase, iodothyronine, type 3
  • iodothyronine deiodinase, placental type
  • thyroxine deiodinase type III (selenoprotein)
  • type 3 iodothyronine selenodeiodinase
  • type-III 5' deiodinase
  • iodothyronine deiodinase type III
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