Browse our FNDC5 Proteins (FNDC5)

Full name:
Fibronectin Type III Domain Containing 5 Proteins (FNDC5)
On are 28 Fibronectin Type III Domain Containing 5 (FNDC5) Proteins from 7 different suppliers available. Additionally we are shipping FNDC5 Kits (73) and FNDC5 Antibodies (63) and many more products for this protein. A total of 178 FNDC5 products are currently listed.
1500001L03Rik, AI836596, C87088, fndc5, FRCP2, irisin, PeP, Pxp, si:dkey-264p5.1, zgc:158684
list all proteins Gene Name GeneID UniProt
FNDC5 252995 Q8NAU1
FNDC5 384061 Q8K4Z2
FNDC5 260327 Q8K3V5

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FNDC5 Proteins (FNDC5) by Origin

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Top referenced FNDC5 Proteins

  1. Human FNDC5 Protein expressed in Wheat germ - ABIN1354283 : Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012 (PubMed)
    Show all 3 references for 1354283

More Proteins for FNDC5 Interaction Partners

Cow (Bovine) Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.

Human Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. Irisin levels are lower in MI and CAD implying that their production may depend on myocardial blood supply.

  2. findings suggest that irisin plays an important role in metabolic disorders and may be affected by physiopathological status.

  3. The FNDC5 rs3480 variant is associated with protection from clinically significant fibrosis in patients with NAFLD, while irisin expression is correlated with the severity of NAFLD and may be involved in extracellular matrix deposition. These data suggest that irisin is involved in regulation of hepatic fibrogenesis.

  4. The median irisin levels were determined higher in T1DM group compared to the control one.

  5. The modulation of body composition and muscle strength induced by 16-week of resistance training in older women with and without obesity is not associated with changes in circulating Irisin levels.

  6. serum irisin levels were correlated with anthropometric and metabolic markers of obesity and type 2 diabetes mellitus .

  7. Plasma irisin modestly increases during moderate and high-intensity afternoon exercise in obese females.

  8. correlation between irisin and adiposity related factors suggests that that in the case of this clinical model, irisin is regulated by adiposity and not by GH

  9. Collectively, our study identified serum irisin as a predictive biomarker for 1-year all-cause mortality in acute heart failure patients though large multicenter studies are highly needed.

  10. T2DM and diabetic nephropathy are associated with decreased levels of irisin. FNDC5 rs16835198 TT genotype associates with decreased risk of T2DM in Egyptians with no effect on renal complications. Also, G allele has insulin (show INS Proteins) desensitizing action with no association with circulating irisin levels.

Mouse (Murine) Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD without significant fibrosis.

  2. Irisin improved endothelial function by modulating HO-1 (show HMOX1 Proteins)/ adiponectin (show ADIPOQ Proteins) axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.

  3. results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Proteins) degradation.

  4. The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 Proteins)/mTOR (show FRAP1 Proteins) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.

  5. This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 Proteins)) overproduction, which could suggest its potential anti-inflammatory properties.

  6. No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.

  7. Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Proteins).

  8. PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.

  9. it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells

  10. Irisin directly targets osteoblast, promoting osteoblast proliferation and differentiation via activating P38/ERK MAP kinase (show MAPK1 Proteins) signaling cascades in vitro.

FNDC5 Protein Profile

Protein Summary

mouse homolog is linked to myoblast differentiation and development

Alternative names and synonyms associated with FNDC5

  • fibronectin type III domain containing 5 (FNDC5)
  • fibronectin type III domain containing 5 (Fndc5)
  • fibronectin type III domain containing 5b (fndc5b)
  • 1500001L03Rik protein
  • AI836596 protein
  • C87088 protein
  • fndc5 protein
  • FRCP2 protein
  • irisin protein
  • PeP protein
  • Pxp protein
  • si:dkey-264p5.1 protein
  • zgc:158684 protein

Protein level used designations for FNDC5

fibronectin type III domain-containing protein 5 , fibronectin type III domain containing 5 , fibronectin type III repeat-containing protein 2 , peroxisomal protein

419667 Gallus gallus
487302 Canis lupus familiaris
538905 Bos taurus
746970 Pan troglodytes
252995 Homo sapiens
384061 Mus musculus
260327 Rattus norvegicus
100726842 Cavia porcellus
101104971 Ovis aries
555635 Danio rerio
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