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Human FNDC5 Protein expressed in Wheat germ - ABIN1354283
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
Show all 3 references for ABIN1354283
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
serum irisin levels are related to visceral adiposity in non-diabetic hemodialysis patients
there is a significant association between circulating irisin and a favourable lipid profile in the general population, suggesting a role in reduced risk for non-communicable diseases
The higher serum irisin concentrations at baseline and in response to insulin (show INS Proteins) infusion might be secondary to insulin (show INS Proteins) resistant conditions in PCOS women.
Central inhibitory effects on feeding induced by irisin
Low Circulating Irisin Levels are associated with Insulin (show INS Proteins) Resistance and Oxidative Stress in Obese Women.
Circulating levels of irisin were increased by 8 weeks of resistance training in overweight/obese adults.
Low Circulating Irisin Levels are associated with Diabetes Mellitus.
Increased irisin immunoreactivity in tissues obtained from breast, ovary, cervix carcinomas, and endometrial hyperplasia suggest critical role of this peptide during carcinogenesis.
Behcet's disease (BD) is characterized by chronic inflammation, and low serum irisin levels in BD may be related to atherosclerosis.
Circulating irisin levels are associated with a beneficial metabolic profile but not with other adipokines and not with rs726344 in our cohort. Our data suggest a potential favorable role of irisin in the regulation of metabolism.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Proteins).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells
Irisin directly targets osteoblast, promoting osteoblast proliferation and differentiation via activating P38/ERK MAP kinase (show MAPK1 Proteins) signaling cascades in vitro.
irisin does not function through inflammatory NFKB activation like other myokines (such as TNFalpha (show TNF Proteins)).
Muscle FNDC5 mRNA expression and irisin release are not IL-15 (show IL15 Proteins)-dependent in mice.
irisin alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative stresses through inhibiting signaling pathways suggesting that irisin may be a promising molecule for the treatment of vascular complications of diabetes.
HFD induced obese mice showed decreased irisin secretion from adipose tissues, which might contribute to muscle insulin (show INS Proteins) resistance.
Our study also suggests the existence of irisin-specific receptor on the membrane of H9C2 cells. In conclusion, irisin in a certain concentration rage (show AGER Proteins) increased myocardial cell metabolism, inhibited cell proliferation and promoted cell differentiation
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein