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Browse our FNDC5 Proteins (FNDC5)

Full name:
Fibronectin Type III Domain Containing 5 Proteins (FNDC5)
On are 27 Fibronectin Type III Domain Containing 5 (FNDC5) Proteins from 7 different suppliers available. Additionally we are shipping FNDC5 Kits (65) and FNDC5 Antibodies (45) and many more products for this protein. A total of 152 FNDC5 products are currently listed.
1500001L03Rik, AI836596, C87088, fndc5, FRCP2, irisin, PeP, Pxp, si:dkey-264p5.1, zgc:158684
list all proteins Gene Name GeneID UniProt
FNDC5 252995 Q8NAU1
FNDC5 384061 Q8K4Z2
FNDC5 260327 Q8K3V5

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FNDC5 Proteins (FNDC5) by Origin

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Top referenced FNDC5 Proteins

  1. Human FNDC5 Protein expressed in Wheat germ - ABIN1354283 : Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012 (PubMed)
    Show all 3 references for ABIN1354283

More Proteins for FNDC5 Interaction Partners

Cow (Bovine) Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.

Human Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. serum irisin levels are related to visceral adiposity in non-diabetic hemodialysis patients

  2. there is a significant association between circulating irisin and a favourable lipid profile in the general population, suggesting a role in reduced risk for non-communicable diseases

  3. The higher serum irisin concentrations at baseline and in response to insulin (show INS Proteins) infusion might be secondary to insulin (show INS Proteins) resistant conditions in PCOS women.

  4. Central inhibitory effects on feeding induced by irisin

  5. Low Circulating Irisin Levels are associated with Insulin (show INS Proteins) Resistance and Oxidative Stress in Obese Women.

  6. Circulating levels of irisin were increased by 8 weeks of resistance training in overweight/obese adults.

  7. Low Circulating Irisin Levels are associated with Diabetes Mellitus.

  8. Increased irisin immunoreactivity in tissues obtained from breast, ovary, cervix carcinomas, and endometrial hyperplasia suggest critical role of this peptide during carcinogenesis.

  9. Behcet's disease (BD) is characterized by chronic inflammation, and low serum irisin levels in BD may be related to atherosclerosis.

  10. Circulating irisin levels are associated with a beneficial metabolic profile but not with other adipokines and not with rs726344 in our cohort. Our data suggest a potential favorable role of irisin in the regulation of metabolism.

Mouse (Murine) Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.

  2. Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Proteins).

  3. PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.

  4. it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells

  5. Irisin directly targets osteoblast, promoting osteoblast proliferation and differentiation via activating P38/ERK MAP kinase (show MAPK1 Proteins) signaling cascades in vitro.

  6. irisin does not function through inflammatory NFKB activation like other myokines (such as TNFalpha (show TNF Proteins)).

  7. Muscle FNDC5 mRNA expression and irisin release are not IL-15 (show IL15 Proteins)-dependent in mice.

  8. irisin alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative stresses through inhibiting signaling pathways suggesting that irisin may be a promising molecule for the treatment of vascular complications of diabetes.

  9. HFD induced obese mice showed decreased irisin secretion from adipose tissues, which might contribute to muscle insulin (show INS Proteins) resistance.

  10. Our study also suggests the existence of irisin-specific receptor on the membrane of H9C2 cells. In conclusion, irisin in a certain concentration rage (show AGER Proteins) increased myocardial cell metabolism, inhibited cell proliferation and promoted cell differentiation

FNDC5 Protein Profile

Protein Summary

mouse homolog is linked to myoblast differentiation and development

Alternative names and synonyms associated with FNDC5

  • fibronectin type III domain containing 5 (FNDC5)
  • fibronectin type III domain containing 5 (Fndc5)
  • fibronectin type III domain containing 5b (fndc5b)
  • 1500001L03Rik protein
  • AI836596 protein
  • C87088 protein
  • fndc5 protein
  • FRCP2 protein
  • irisin protein
  • PeP protein
  • Pxp protein
  • si:dkey-264p5.1 protein
  • zgc:158684 protein

Protein level used designations for FNDC5

fibronectin type III domain-containing protein 5 , fibronectin type III domain containing 5 , fibronectin type III repeat-containing protein 2 , peroxisomal protein

419667 Gallus gallus
487302 Canis lupus familiaris
538905 Bos taurus
746970 Pan troglodytes
252995 Homo sapiens
384061 Mus musculus
260327 Rattus norvegicus
100726842 Cavia porcellus
101104971 Ovis aries
555635 Danio rerio
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