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Human FNDC5 Protein expressed in Wheat germ - ABIN1354283
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
Show all 3 Pubmed References
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
HCC (show FAM126A Proteins)-liver tissue over-expressed FNDC5/Irisin in association with gene expression of mediators involved in lipogenesis, inflammation and cancer, suggesting a possible protective role of the hormone from the liver damage.
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (show INS Proteins) biosynthesis and glucose-stimulated insulin (show INS Proteins) secretion, and beta-cell apoptosis are reported.
Irisin regulates the number and function of endothelial progenitor cells via the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/eNOS (show NOS3 Proteins) pathway in mouse model of diabetes mellitus.
there is a correlation between sport performance, insulin (show INS Proteins) sensitivity, and irisin levels
results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (show ROS1 Proteins)-NLRP3 (show NLRP3 Proteins) inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke.
These data indicate that increased irisin levels may have protective roles in liver cancer cells through partial activation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy.
Decreased serum irisin levels are related to emphysema in patients with COPD (show ARCN1 Proteins) and involved in epithelial apoptosis, resulting in emphysema.
Irisin levels are lower in MI and CAD implying that their production may depend on myocardial blood supply.
findings suggest that irisin plays an important role in metabolic disorders and may be affected by physiopathological status.
The FNDC5 rs3480 variant is associated with protection from clinically significant fibrosis in patients with NAFLD, while irisin expression is correlated with the severity of NAFLD and may be involved in extracellular matrix deposition. These data suggest that irisin is involved in regulation of hepatic fibrogenesis.
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (show HMOX1 Proteins)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Proteins) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 Proteins)/mTOR (show FRAP1 Proteins) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 Proteins)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Proteins).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein