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anti-Mouse (Murine) IGF2 Antibodies:
anti-Rat (Rattus) IGF2 Antibodies:
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Human Polyclonal IGF2 Primary Antibody for Func, ELISA - ABIN2474321
Terasawa, Kohda, Hatanaka, Nagata, Higashihashi, Fujiwara, Sakano, Inagaki: Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins. in The EMBO journal 1995
Show all 2 Pubmed References
Human Polyclonal IGF2 Primary Antibody for ELISA, WB - ABIN2474322
Singer, Mogg, Koestler, Pacher, Marton, Kubista, Schreiber: Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Show all 2 Pubmed References
Mouse (Murine) Polyclonal IGF2 Primary Antibody for ELISA, IHC - ABIN4321596
Fernandez-L, Squatrito, Northcott, Awan, Holland, Taylor, Nahlé, Kenney: Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation. in Oncogene 2012
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
The IGF2 expression has also been reported at earlier stages in fish.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
Loss of Igf2 Gene Imprinting is associated with Prostate Cancer.
IGF2 controls bone growth by regulating glucose metabolism in chondrocytes.
These results demonstrate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage testing of MEDI-573, alone and in combinations, in IGF2-overexpressing CRC (show SCRIB Antibodies) patients.
results demonstrate that the H19 (show NCKAP1 Antibodies)-Igf2 axis is negatively regulated by CTCF (show CTCF Antibodies)-PHB1 (show PHB Antibodies) cooperation and that H19 (show NCKAP1 Antibodies) is involved in modulating the growth-suppressive effect of PHB1 (show PHB Antibodies) in the liver.
Our study reveals that the expression level of Igf2 is critical to maintain the balance between stem cell self-renewal and differentiation, presumably by regulating the interaction between HSC (show FUT1 Antibodies) and their niche.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.
analysis of the distal muscle enhancer in the mouse Igf2 locus
Data indicate that the effects of insulin-like growth factor 2 (IGF2) are mediated by direct upregulation of the cyclin-dependent kinase inhibitor p57 (p57 (show CDKN1C Antibodies)).
Mstn may negatively regulate Igf2 expression to control postnatal skeletal muscle growth, however differences in growth between male and female mice are not readily explained by changes in expression of Igf family members.
a mitogenic growth factor\; may have a role in fetal development
insulin-like growth factor II
, insulin-like growth factor 2
, insulin-like growth factor 2b
, insulin-like growth factor 2-A
, insulin-like growth factor II-A
, multiplication-stimulating polypeptide
, Insulin-like growth factor II (somatomedin A)
, insulin-like growth factor II (IGF-II)
, insulin-like growth factor II isoform 2 variant 4 preprotein
, multiplication-stimulating activity