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Human Monoclonal HNF1A Primary Antibody for IF, WB - ABIN968241
Frain, Swart, Monaci, Nicosia, Stämpfli, Frank, Cortese: The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. in Cell 1989
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Human Monoclonal HNF1A Primary Antibody for IF, WB - ABIN968240
Kritis, Ktistaki, Barda, Zannis, Talianidis: An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression. in Nucleic acids research 1994
Show all 5 Pubmed References
Human Polyclonal HNF1A Primary Antibody for ICC, IF - ABIN443456
Yasui, Miyoshi, Tababe, Ishigami, Fukutomi, Imai, Isemura: Effects of oolong tea on gene expression of gluconeogenic enzymes in the mouse liver and in rat hepatoma H4IIE cells. in Journal of medicinal food 2011
Show all 2 Pubmed References
Dog (Canine) Polyclonal HNF1A Primary Antibody for ELISA - ABIN188701
Hansen, Párrizas, Jensen, Pruhova, Ek, Boj, Johansen, Maestro, Rivera, Eiberg, Andel, Lebl, Pedersen, Ferrer, Hansen: Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function. in The Journal of clinical investigation 2002
Cow (Bovine) Polyclonal HNF1A Primary Antibody for IHC, WB - ABIN2784536
Scheving, Zhang, Garcia, Wang, Stevenson, Threadgill, Russell: Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. in American journal of physiology. Gastrointestinal and liver physiology 2014
Lef1 (show LEF1 Antibodies) and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
HNF1alpha, which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 (show PDZK1 Antibodies) transcription.
Results identified HNF1A/B as a good candidates to master the regulation of pancreatic differentiation, which at the protein level loses its expression in malignant ductal cells of the pancreas, suggesting its putative role as tumor suppressor in pancreatic cancer.
this study found that 20%-60% of Hepatit (show CD8A Antibodies)is C-specific CD8+ T cells were Tcf1+
Findings suggest that there are subtypes of T2DM characterized by different urinary glucose excretion and cardiovascular risk factors. SLC5A2 (show SLC5A2 Antibodies) and HNF1A mutations partially explain renal glycosuria in patients with T2DM.
Results indicate that HNF1alpha can modulate the expression of hepatitis B virus (HBV) large surface proteins to interfere virion production, and HNF1alpha is capable of limiting HBV transcription and replication by activating the NF-kappaB (show NFKB1 Antibodies) signaling.
Study have shown that expression of specific miRNAs depends on HNF1beta (show HNF1B Antibodies) function. The impact of HNF1beta (show HNF1B Antibodies) deficiency was evidenced at serum level, making HNF1beta (show HNF1B Antibodies)-dependent miRNAs potentially applicable in the diagnosis of HNF1B (show HNF1B Antibodies)-MODY (show HNF4A Antibodies).
Mutation in HNF1A gene is associated with Maturity Onset Diabetes of the Young.
CRP (show CRP Antibodies) increased PCSK9 (show PCSK9 Antibodies) expression by activating p38MAPK (show MAPK14 Antibodies)-HNF1alpha pathway, with a certain downstream impairment in LDL metabolism in HepG2 cells.
Our data on the first functional study of HNF1A mutations in South India subjects confers that the defect of the HNF-1A mutant proteins are responsible for MODY3 diabetes in these patients
We identified PD-1 (show PDCD1 Antibodies) to be specifically expressed in PLZF (show ZBTB16 Antibodies)(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (show NFIL3 Antibodies), ID2, and TCF-1 was critical. Importantly, induction of ILC (show CCL27 Antibodies) lineage commitment required only transient expression of NFIL3 (show NFIL3 Antibodies) prior to ID2 and TCF-1 expression.
Knockdown of MACF1 (show MACF1 Antibodies) in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin (show CTNNB1 Antibodies)/TCF1-Runx2 (show RUNX2 Antibodies) axis.
this study found that virus-specific CD8 (show CD8A Antibodies)(+) T cells that sustained the T cell response during chronic viral infection are defined by, and depended on, the expression of Tcf1
data demonstrate a novel miR (show MLXIP Antibodies)-24-TCF1 pathway in controlling effector cytokine production by T cells and further suggest miR (show MLXIP Antibodies)-24 could function as a key upstream molecule regulating TCF1-mediated immune responses.
HNF1alpha plays a crucial role in hepatocyte lipid metabolism and hepatocarcinogenesis
Data show that TCF1 proteindeficiency relieved most manifestations of autoimmune lymphoproliferative syndrome (ALPS)-like phenotype, which were caused by Fas (show FAS Antibodies) protein mutation in TCF1(-/-) lpr/lpr (show FAS Antibodies) mice.
Data show that the Wnt (show WNT2 Antibodies)-effector hepatocyte nuclear factor 1-alpha (Tcf1) is recruited to and triggers transcription of the Ink4/Arf (show CDKN2A Antibodies) tumor suppressor locus, such as as p15Ink4b (show CDKN2B Antibodies), p16Ink4a (show CDKN2A Antibodies) and p19Arf (show CDKN2A Antibodies).
this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1, GATA-3 (show GATA3 Antibodies) and Runx1 (show RUNX1 Antibodies)) activate Bcl11b (show BCL11B Antibodies) for T cell commitment
this study shows that the transcription factors Tcf1 and Lef1 (show LEF1 Antibodies) suppress CD4 (show CD4 Antibodies)+ T lineage genes in CD8 (show CD8A Antibodies)+ T cells through intrinsic histone deacetylase (show HDAC1 Antibodies) activity
pigs harboring the dominant-negative mutant human MODY3 gene showed reproducible and distinct glomerular nodules.
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.
HNF1 homeobox A
, albumin proximal factor
, hepatic nuclear factor 1
, hepatocyte nuclear factor 1-alpha
, interferon production regulator factor
, liver-specific transcription factor LF-B1
, transcription factor 1, hepatic
, hepatic nuclear factor (HNF1)
, transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor
, hepatocyte nuclear factor 1
, transcription factor 1
, LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1
, LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1
, Transcription factor 1 hepatic
, Transcription factor 1, hepatic
, hepatic nuclear factor-1-alpha
, hepatocyte nuclear factor 1 alpha