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a novel role for Bassoon (show BSN ELISA Kits) and Piccolo as critical regulators of presynaptic ubiquitination and proteostasis.
Piccolo is an important regulator of presynaptic F-actin, functioning to coordinate its activity-dependent assembly and thereby modulating neurotransmitter release.
piccolo and bassoon (show BSN ELISA Kits) play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release.
Piccolo plays a pivotal role in synaptic plasticity in area CA1 (show CA1 ELISA Kits) and in hippocampus-dependent learning in mice; the extracellular levels of glutamate (show GRIN1 ELISA Kits) in the hippocampus under stimulated conditions are controlled by Piccolo.
binds to cAMP-GEFII (show RAPGEF4 ELISA Kits) and forms both homodimer and heterodimer with Rim2 (show AP3B1 ELISA Kits) in a Ca(2 (show CA2 ELISA Kits)+)-dependent manner, whereas Rim2 (show AP3B1 ELISA Kits) alone does not form the homodimer
These results suggest that Piccolo is a components of neuromuscular junction synapses in the peripheral nervous system.
Piccolo C2A domain may act as a cytoskeletal regulator for plasmalemmal DAT (show SLC6A3 ELISA Kits) internalization, which may underlie its contributions in behavioral plasticity.
Piccolo contributes to tumor aggressiveness in esophageal squamous cell carcinoma, likely by stabilizing EGFR (show EGFR ELISA Kits) and promoting EGFR (show EGFR ELISA Kits)-dependent signaling.
Results provide some support for the involvement of BICC1 (show BICC1 ELISA Kits) and PCLO in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes
Study created and characterized a knock-in mouse model carrying the PCLO Ser (show SIGLEC1 ELISA Kits) to Ala missense variant rs2522833, which has shown suggestive association with major depressive disorder in human population studies
PCLO intron rs13438494 is associated with drug abuse and contributes to the pathogenesis of psychiatric disorders via modulation of neurotransmitter turnover.
PCLO risk allele carrying remitted depressed patients did not show more negatively biased memory than non-risk allele carriers, not even patients with stressful childhood events.
The subsequent validation study on 68 LCBs identified recurrent mutations in TERT promoter, chromatin regulators (BAP1, PBRM1 and ARID2), a synapse organization gene (PCLO), IDH genes and KRAS.
A homozygous, nonsense PCLO mutation underlies the autosomal recessive neurodegenerative disorder pontocerebellar hypoplasia type III.
PCLO and CACNA1C (show CACNA1C ELISA Kits) depression risk alleles jointly affect memory-related subgenual cingulate activity.
For neither PCLO nor GRM7 (show GRM7 ELISA Kits) we found a more associated variant. For SLC6A4 (show SLC6A4 ELISA Kits), we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS
The results demonstrate that rs13438494 intron 24 of PCLO gene alters the splicing efficiency by creating or disrupting a splicing motif that functions by binding of the splicing regulatory protein and may ultimately influence bipolar disorder.
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene.
piccolo (presynaptic cytomatrix protein)
, protein piccolo-like
, brain-derived HLMN protein
, multidomain presynaptic cytomatrix protein
, protein piccolo
, multidomain presynaptic cytomatrix protein Piccolo
, presynaptic cytomatrix protein