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Browse our IGF1 Proteins (IGF1)

Full name:
Insulin-Like Growth Factor I Proteins (IGF1)
On are 3 Insulin-Like Growth Factor I (IGF1) Proteins from 1 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 6 IGF1 products are currently listed.
C730016P09Rik, IGF-1, IGF-I, IGF-IB, IGF1, IGF1A, IGFI, IGFIA, Npt2B
list all proteins Gene Name GeneID UniProt
Mouse IGF1 IGF1 16000 P05017
Rat IGF1 IGF1 24482 P08025
IGF1 3479 P05019

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IGF1 Proteins (IGF1) by Origin

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More Proteins for IGF1 Interaction Partners

Mouse (Murine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Under nonpathological conditions, IGF-1 regulates brain IGF-IR

  2. These findings highlight the sex-dependent and potentially detrimental effects of in utero smoke exposure on DNA methylation (show HELLS Proteins) and Igf1 and Igf1r (show IGF1R Proteins) mRNA levels.

  3. Liver-derived IGF-I regulates cortical bone mass, cortical porosity, and mechanical strength under normal (nonloaded) conditions. However, despite an approximately 70% reduction in circulating IGF-I, the osteogenic response to mechanical loading was not attenuated in the LI-IGF-I(-/-) mice.

  4. The effects were abolished by using pharmacological inhibition of PI3K/Akt (show AKT1 Proteins) with LY294002 and paralleled by transfecting DCs with klotho (show KL Proteins) siRNA. In conclusion, the regulation of klotho (show KL Proteins) sensitive DC function by IGF-1 or insulin (show INS Proteins) is mediated through PI3K/Akt (show AKT1 Proteins) signaling pathway in BMDCs.

  5. These results show that IGF1 signaling shapes the macrophage-activation phenotype.

  6. Serum IGF-1 level of HFD TRAMP (show DPT Proteins) mice was significantly higher than that of normal diet TRAMP (show DPT Proteins) mice, increasing with age. The IGF-1 related pathway played an important role in high-fat diet promotion of TRAMP (show DPT Proteins) mouse PCa (show ENPP1 Proteins) development and progression.

  7. Upregulation of miR26b in mouse cells downregulated the insulinlike growth factor 1 (IGF1) protein expression level and promoted beta-amyloid production.

  8. These results indicate that there is a tissue-specific regulation of IGF-1/PI3K/Akt (show AKT1 Proteins) during normal aging and upon dietary restriction to help maintain the metabolic status of these tissues at those phases of animal's lifespan.

  9. IGF-1 deficiency is responsible for increased brain oxidative damage, edema, and impaired learning and memory capabilities which are rescued by IGF-1 replacement therapy.

  10. these data suggest the age-related loss of vertebral bone density in females can be reduced by modifying circulating IGF-1 levels early in life.

Guinea Pig Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.

Human Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Plasma IGF1 was elevated in patients with systemic sclerosis.

  2. physiological levels of GH rapidly stimulate human IGF1 gene transcription and identify several potential transcriptional enhancers in chromatin that bind STAT5b (show STAT5B Proteins) in a GH-regulated way. Each of the putative enhancers also activates a human IGF1 gene promoter in reconstitution experiments in the presence of the GH receptor (show GHR Proteins), STAT5b (show STAT5B Proteins), and GH.

  3. The total number of different alleles detected per gene in the population varied over an approximately 15-fold range, from 57 for IGF1 to 872 for IGF2R (show IGF2R Proteins), although when corrected for protein length the rate ranged from 0.22 to 0.59 changes/codon among the 11 genes evaluated.

  4. Growth velocity in infants is influenced by associations between levels of testosterone, estradiol, and IGF1.

  5. We concluded that USP15 (show USP15 Proteins) attenuates IGF-I signaling by antagonizing Nedd4 (show NEDD4 Proteins)-induced IRS-2 (show IRS2 Proteins) ubiquitination.

  6. this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci.

  7. these findings suggest that IGFBP-3 (show IGFBP3 Proteins) suppresses transcription of EGR1 (show EGR1 Proteins) and its target genes bFGF (show FGF2 Proteins) and PDGF (show PDGFA Proteins) through inhibiting IGF-1-dependent ERK (show EPHB2 Proteins) and AKT (show AKT1 Proteins) activation.

  8. No association between physical activity or fitness in adolescence and cognitive function in adulthood was found in females, nor any intermediate role for IGF-I in either sex.

  9. Short-term treatment with progressive doses of rhIGF1 (recombinant human insulin-like growth factor-1) improved growth in two siblings with deficiency of PAPP-A2 (pregnancy-associated plasma protein-A2 (show PAPPA2 Proteins)) [due to a homozygous loss-of-function frameshift mutation in exon 3 of the PAPP-A2 (show PAPPA2 Proteins) gene (p.D643fs25*)] that resulted in postnatal growth failure due to resulting decrease in IGF1 bioavailability. [CASE REPORT]

  10. This is the first study demonstrating Treg-enhancing effects of IGF-1. Thus IGF-1 can be accounted for modulating Treg cell-related action in Graves' Orbitopathy

Cow (Bovine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.

  2. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (show STAT5A Proteins) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

  3. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

  4. The association of IGF1, GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.

  5. These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Proteins) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

  6. Insulin (show INS Proteins)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Proteins)-mediated signaling pathways.

  7. Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

  8. Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.

  9. This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.

  10. Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.

Pig (Porcine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (show HGF Proteins) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

  2. Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.

  3. genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.

  4. IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.

  5. IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.

  6. alpha-linolenic acid increased IGF-I secretion from hepatocytes.

  7. Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.

  8. The results show that modulation of plasma insulin (show INS Proteins) levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I levels are less easily modified.

  9. The results suggested that IFG (show IFNG Proteins)-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.

  10. Plasma ghrelin (show GHRL Proteins) level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma IGF-1 level and myocardial ghrelin (show GHRL Proteins) mRNA expression were down-regulated in the chronic cyanotic immature piglets.

Rabbit Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

  2. Our studies demonstrate that the active SVCT2 (show SLC23A2 Proteins) is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.

  3. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.

  4. IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors

  5. Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.

Horse (Equine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor (show IGF1R Proteins) and the effect of dietary carbohydrates on their expression are reported.

  3. Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.

  4. Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Proteins) is present in spermatogonia, spermatocytes and Leydig cells.

  5. Hsp90 (show HSP90AB1 Proteins) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.

Rainbow Trout (Oncorhynchus mykiss) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Findings show similar regulatory growth hormone (GH (show GH1 Proteins)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.

  2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (show TNF Proteins).

  3. Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.

Goat Insulin-Like Growth Factor I (IGF1) interaction partners

  1. These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.

IGF1 Protein Profile

Protein Summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with IGF1

  • insulin-like growth factor 1 (Igf1)
  • insulin-like growth factor 1 (somatomedin C) (IGF1)
  • insulin-like growth factor I (LOC100136741)
  • prepro IGF-I (IGF-I)
  • C730016P09Rik protein
  • IGF-1 protein
  • IGF-I protein
  • IGF-IB protein
  • IGF1 protein
  • IGF1A protein
  • IGFI protein
  • IGFIA protein
  • Npt2B protein

Protein level used designations for IGF1

insulin-like growth factor I , somatomedin , IGF-I , IGF-IA , IGF-IB , MGF , insulin-like growth factor 1 , insulin-like growth factor IA , insulin-like growth factor IB , mechano growth factor , somatomedin-C , insulin-like growth factor-1 , class 1 insulin-like growth factor I preproprotein , insulin growth factor-1 , insulin like growth factor 1 , insulin-like growth factor I (somatomedin C) , insulin-like growth factor I variant 1 , prepro-IGF-I , somatomedin C , Insulin-like growth factor I , Somatomedin , insulin like growth factor-1 , insulin-like growth factor-I

16000 Mus musculus
100135551 Cavia porcellus
24482 Rattus norvegicus
3479 Homo sapiens
418090 Gallus gallus
281239 Bos taurus
397491 Sus scrofa
443318 Ovis aries
100008668 Oryctolagus cuniculus
610255 Canis lupus familiaris
100034198 Equus caballus
100136741 Oncorhynchus mykiss
100860838 Capra hircus
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