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T3 promotes differentiation towards chondrocytes-like cells in our in vitro model, that this differentiation is mediated by steroid receptor (show ESR2 Proteins) co-activator 2 (SRC2) and does not induce hypertrophy
Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1 (show HEY1 Proteins)-NCOA2 gene fusion.
Data suggest that steroid receptor (show ESR2 Proteins) coactivators (NCOA1 (show NCOA1 Proteins), NCOA2, NCOA3 (show NCOA3 Proteins)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 Proteins) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
SRC-2 may exhibit oncogenic or tumor suppressor activity depending on the target genes and nuclear receptors that are expressed in distinct tissues
NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 (show SRC Proteins) domain of NCOA2 and the ETS (show ETS1 Proteins) DNAbinding domain of ETV4 (show ETV4 Proteins).
Altered expression of TIF2 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system.
evaluating if NCOA2 relative copy-number gain presents prognostic value for prostate cancer
Report NcoA2-regulation of the AhR (show AHR Proteins)-ARNT (show ARNT Proteins)-HIF-1a (show HIF1A Proteins) interaction.
Data suggest that LRH1/NR5A2 (show NR5A2 Proteins) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 and SHP (show LAMC1 Proteins) (co-repressor; small heterodimer partner (show NR0B2 Proteins) protein).
NCOA2 is a novel negative growth regulatory gene repressing the Wnt/beta-catenin pathway in colorectal cancer, where recurrent fusion with LACTB2 contributes to its disruption.
studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver
the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
findings position SRC-2 as a major regulator of polygenic inputs to metabolic gene regulation and perhaps identify a previously unappreciated model that helps to explain the clinical spectrum of glucose dysregulation
fetal lungs produce signals to initiate labor when mature, and SRC-1 (show NCOA1 Proteins)/-2-dependent production of SP-A (show SFTPA1 Proteins) and PAF (show KIAA0101 Proteins) is crucial for this process
In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia.
the PAX3 (show PAX3 Proteins)-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma
Transcription factor 23 (Tcf23 (show TCF23 Proteins)), a basic-helix-loop-helix transcription factor (show HEY1 Proteins), is a new progesterone-induced target gene that requires SRC-2 for full induction.
SRC-2 is a transcriptional coactivator for BMAL1 (show ARNTL Proteins):CLOCK. Ablation of SRC-2 disrupts the central clock.
SRC-2 is critical to transcriptional control modulated by MEF2 (show MEF2C Proteins), GATA-4 (show GATA4 Proteins), and Tbx5 (show TBX5 Proteins), thereby enhancing gene expression associated with cardiac growth.
SRC2 regulates anxiety response with SRC2(-/-) females showing decreased anxiety in novel environments.
The tif2 is involved in embryogenesis and in primitive hematopoiesis. tif2-knockdown zebrafish embryos are smaller than controls.
SNP 1718 in the NCOA2 gene was significant for early pregnancy probability (P=0.02) and age at first calving (P=0.03), and SNP 2038 in the same gene was significant for days to calving (P=0.03).
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997
class E basic helix-loop-helix protein 75
, glucocorticoid receptor-interacting protein-1
, transcriptional intermediary factor 2
, glucocorticoid receptor interacting protein 1
, glucocorticoid receptor-interacting protein 1
, steroid receptor coactivator 2
, nuclear receptor coactivator 2
, transcriptional intermediary factor-2
, Transcriptional intermediary factor 2
, nuclear receptor coactivator 2-like