NCOA2 Products
(Nuclear Receptor Coactivator 2 (NCOA2))
Categories
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010].
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Featured NCOA2 Categories
NCOA2 Antibodies
High quality antibodies with extensive validation data.
NCOA2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NCOA2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN6144413
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7255239
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (1)
- (2)
Cat. No.
ABIN2780788
Quantity
100 μL
Datasheet
Datasheet
Recommended NCOA2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312126
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3094110
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3135340
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NCOA2 products
: "Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules." in: Current biology : CB, Vol. 27, Issue 11, pp. 1692-1699.e3, (2018) (PubMed).: "Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus(1,2,3)." in: eNeuro, Vol. 2, Issue 4, (2015) (PubMed).
: "Interaction of STAT6 with its co-activator SRC-1/NCoA-1 is regulated by dephosphorylation of the latter via PP2A." in: Nucleic acids research, Vol. 39, Issue 8, pp. 3255-66, (2011) (PubMed).
: "Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain." in: Neuroendocrinology, Vol. 94, Issue 1, pp. 49-57, (2011) (PubMed).
: "Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica)." in: Journal of neurochemistry, Vol. 119, Issue 3, pp. 579-93, (2011) (PubMed).
: "ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 4, pp. 977-83, (2008) (PubMed).
: "The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus." in: The EMBO journal, Vol. 21, Issue 4, pp. 736-48, (2002) (PubMed).
: "Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene." in: Science (New York, N.Y.), Vol. 279, Issue 5358, pp. 1922-5, (1998) (PubMed).
: "A signature motif in transcriptional co-activators mediates binding to nuclear receptors." in: Nature, Vol. 387, Issue 6634, pp. 733-6, (1997) (PubMed).
: "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors." in: The EMBO journal, Vol. 15, Issue 14, pp. 3667-75, (1996) (PubMed).
Synonyms and alternative names related to NCOA2
nuclear receptor coactivator 2 (NCOA2), nuclear receptor coactivator 2 (Ncoa2), nuclear receptor coactivator 2 (ncoa2), nuclear receptor coactivator 2 (LOC100089041), nuclear receptor coactivator 2 S homeolog (ncoa2.S), 9530095N19, bHLHe75, bhlhe75, D1Ertd433e, GRIP-1, GRIP1, Grip1, grip1, KAT13C, kat13c, NCoA-2, NCOA2, ncoa2-A, SRC-2, SRC2, src2, TIF-2, TIF2, tif2, Tif2, wu:fc41a10, wu:fe26a11, XTIF2Protein level used designations for NCOA2
- class E basic helix-loop-helix protein 75
- glucocorticoid receptor-interacting protein-1
- hTIF2
- transcriptional intermediary factor 2
- NCoA-2
- TIF2/GRIP-1
- glucocorticoid receptor interacting protein 1
- glucocorticoid receptor-interacting protein 1
- grip1
- src2
- steroid receptor coactivator 2
- nuclear receptor coactivator 2
- transcriptional intermediary factor-2
- Transcriptional intermediary factor 2
- nuclear receptor coactivator 2-like
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