Browse our anti-UBR5 (UBR5) Antibodies

Full name:
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 Antibodies (UBR5)
On are 83 Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Antibodies from 18 different suppliers available. Additionally we are shipping UBR5 Kits (3) and and many more products for this protein. A total of 92 UBR5 products are currently listed.
4432411E13Rik, AW549941, C77315, D030042K14, Dd5, Edd, Edd1, HYD, mKIAA0896, Rat100
list all antibodies Gene Name GeneID UniProt
UBR5 51366 O95071
UBR5 70790 Q80TP3
UBR5 117060  

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Most Popular Reactivities for anti-UBR5 (UBR5) Antibodies

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anti-Human UBR5 Antibodies:

anti-Mouse (Murine) UBR5 Antibodies:

anti-Rat (Rattus) UBR5 Antibodies:

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Top referenced anti-UBR5 Antibodies

  1. Human Polyclonal UBR5 Primary Antibody for ICC, IF - ABIN151138 : Nash, Chen, Salganik, Muzyczka: Identification of cellular proteins that interact with the adeno-associated virus rep protein. in Journal of virology 2008 (PubMed)
    Show all 7 references for 151138

  2. Human Polyclonal UBR5 Primary Antibody for IHC (p), IHC - ABIN249850 : Garbow, Doherty, Schugar, Travers, Weber, Wentz, Ezenwajiaku, Cotter, Brunt, Crawford: Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. in American journal of physiology. Gastrointestinal and liver physiology 2011 (PubMed)
    Show all 2 references for 249850

  3. Human Polyclonal UBR5 Primary Antibody for IHC, ELISA - ABIN184976 : Henderson, Russell, Hird, Muñoz, Clancy, Lehrbach, Calanni, Jans, Sutherland, Watts: EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. in The Journal of biological chemistry 2002 (PubMed)

More Antibodies against UBR5 Interaction Partners

Human Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) interaction partners

  1. UBR5 downregulates proapoptotic MOAP-1 (show MOAP1 Antibodies) and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.

  2. Data suggest that UBR5 down-regulates levels of TRAF3 (show TRAF3 Antibodies), a key component of Toll (show TLR4 Antibodies)-like receptor signaling, via the miRNA pathway; p90RSK (show RPS6KA1 Antibodies) is an upstream regulator of UBR5; p90RSK (show RPS6KA1 Antibodies) phosphorylates UBR5 as required for translational repression of TRAF3 (show TRAF3 Antibodies) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (show TRAF3 Antibodies) = TNF receptor-associated factor 3 (show TRAF3 Antibodies); p90RSK (show RPS6KA1 Antibodies) = 90 kDa ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies))

  3. Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1 (show GKN1 Antibodies)) and increased its ubiquitination to reduce the protein stability of GKN1 (show GKN1 Antibodies).

  4. Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.

  5. Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]

  6. Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro

  7. Human herpesvirus-6 U14 induces cell cycle arrest in G2/M phase by associating with a cellular protein, EDD.

  8. Elevated metaphase RanGTP levels use Ubr5 to couple overall chromosome congression to SAC (show ADCY10 Antibodies) silencing.

  9. results confirm the role of the MLLE domain of UBR5 in substrate recruitment and suggest a potential role in regulating UBR5 ligase activity.

  10. these observations highlight the potential role of EDD in regulating mitotic progression and the cellular response to perturbed mitosis.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) interaction partners

  1. Hence, while loss of UBR5 perturbed Hedgehog (show SHH Antibodies) signalling in the developing limb, there were no obvious morphological defects.

  2. Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.

  3. UBR5-mediated ATMIN (show ATMIN Antibodies) ubiquitination is a vital event for ATM (show ATM Antibodies) pathway selection and activation in response to DNA damage

  4. a novel function of RIP1 (show RALBP1 Antibodies) kinase involving its interaction with EDD to regulate JNK (show MAPK8 Antibodies) activation and TNFalpha (show TNF Antibodies) production.

  5. Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.

  6. The SCF (show KITLG Antibodies) E3 ligase complex containing Fbxo40 (show FBXO40 Antibodies) directly ubiquitinates IRS1 (show IRS1 Antibodies), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (show IRS1 Antibodies).

  7. Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.

  8. UBR5 can attenuate myocardin (show MYOCD Antibodies) protein degradation resulting in increased myocardin (show MYOCD Antibodies) protein expression without affecting myocardin (show MYOCD Antibodies) mRNA expression.

  9. Results suggest that Edd has an essential role in extraembryonic development.

UBR5 Antigen Profile

Antigen Summary

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Alternative names and synonyms associated with UBR5

  • ubiquitin protein ligase E3 component n-recognin 5 (UBR5) antibody
  • ubiquitin protein ligase E3 component n-recognin 5 (Ubr5) antibody
  • 4432411E13Rik antibody
  • AW549941 antibody
  • C77315 antibody
  • D030042K14 antibody
  • Dd5 antibody
  • Edd antibody
  • Edd1 antibody
  • HYD antibody
  • mKIAA0896 antibody
  • Rat100 antibody

Protein level used designations for UBR5

E3 identified by differential display , E3 ubiquitin protein ligase, HECT domain containing, 1 , E3 ubiquitin-protein ligase UBR5 , E3 ubiquitin-protein ligase, HECT domain-containing 1 , hHYD , hyperplastic discs protein homolog , progestin induced protein , progestin-induced protein , ubiquitin-protein ligase , extraembryonic development

51366 Homo sapiens
70790 Mus musculus
117060 Rattus norvegicus
420252 Gallus gallus
475055 Canis lupus familiaris
100157625 Sus scrofa
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