UBR5 antibody

Catalog No. ABIN7183479

Product Details anti-UBR5 Antibody

Target: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Internal of Human EDD.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBR5

Target: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Alternative Name: UBR5 (UBR5 Products)

Synonyms: DD5 antibody, EDD antibody, EDD1 antibody, HYD antibody, 4432411E13Rik antibody, AW549941 antibody, C77315 antibody, D030042K14 antibody, Edd antibody, Edd1 antibody, mKIAA0896 antibody, Dd5 antibody, Rat100 antibody, ubiquitin protein ligase E3 component n-recognin 5 antibody, UBR5 antibody, Ubr5 antibody

Background:

Background: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation By similarity. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Michelle J. Henderson, J. Biol. Chem., Dec 2006, 281: 39990 - 40000.
Lisa N. Kinch, Protein Sci., Feb 2005, 14: 360 - 367.
Michelle J. Henderson, J. Biol. Chem., Jul 2002, 277: 26468 - 26478.
Darren N. Saunders, Mol. Cell. Biol., Aug 2004, 24: 7225 - 7

Aliases: 4432411E13Rik antibody, AW549941 antibody, C77315 antibody, D030042K14 antibody, DD5 antibody, E3 identified by differential display antibody, E3 ubiquitin protein ligase, HECT domain containing, 1 antibody, E3 ubiquitin-protein ligase antibody, E3 ubiquitin-protein ligase UBR5 antibody, EDD 1 antibody, EDD antibody, EDD1 antibody, FLJ11310 antibody, HECT domain-containing 1 antibody, hHYD antibody, HYD antibody, Hyperplastic discs protein homolog antibody, Hyperplastic discs, Drosophila, homolog of antibody, KIAA0896 antibody, MGC57263 antibody, mKIAA0896 antibody, Progestin induced protein antibody, Progestin-induced protein antibody, Rat100 antibody, Ubiquitin protein ligase antibody, Ubiquitin protein ligase E3 component n recognin 5 antibody, UBR5 antibody, UBR5_HUMAN antibody

UniProt: O95071

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway