Browse our GNAQ Proteins (GNAQ)

Full name:
Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide Proteins (GNAQ)
On www.antibodies-online.com are 13 Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Proteins from 4 different suppliers available. Additionally we are shipping GNAQ Antibodies (85) and GNAQ Kits (1) and many more products for this protein. A total of 108 GNAQ products are currently listed.
Synonyms:
1110005L02Rik, 6230401I02Rik, AA408290, AW060788, CMC1, Dsk1, Dsk10, g-alpha-q, Galphaq, gaq, Gnaq, gnaqb, Gq, GqI, si:ch73-270f14.2, SWS
list all proteins Gene Name GeneID UniProt
GNAQ 2776 P50148
GNAQ 81666 P82471
GNAQ 14682 P21279

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GNAQ Proteins (GNAQ) by Origin

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More Proteins for GNAQ Interaction Partners

Human Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. Data (including data from studies using cells from knockout mice) suggest that CLEC2 (show CLEC1B Proteins)/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 (show CLEC1B Proteins) = C-type lectin (show MBL2 Proteins) CLEC2 (show CLEC1B Proteins); CLEC2R = CLEC2 (show CLEC1B Proteins) receptor; GNAQ = guanine nucleotide-binding protein (show COASY Proteins) G[q] subunit alpha)

  2. The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b (show CCR2 Proteins)-stimulated Rho A (show RHOA Proteins) GTPase (show RACGAP1 Proteins)-mediated serum response factor activation.

  3. GNAQ/11 mutant clones make up a fraction of the cells in choroidal nevi. Nevus cells are furthermore characterised by heterogeneous YAP (show YAP1 Proteins) expression. Combined GNAQ/11 and YAP (show YAP1 Proteins) may constitute a putative precursor tumour pathway with an activated oncogene (show RAB1A Proteins) (GNAQ/11) and downstream effector (YAP (show YAP1 Proteins)).

  4. RasGRP3 (show RASGRP3 Proteins) mediates ERK MAPK (show MAPK1 Proteins) pathway activation in GNAQ mutant uveal melanoma.

  5. Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (show TH1L Proteins) differentiation

  6. The GC/GC (show GC Proteins) genotype of the TT(-695/-694)GC polymorphism is associated with increased Gq protein expression, augmented angiotensin II receptor type 1 (show AGTR1 Proteins)-related vasoconstriction, and increased myocardial injury after coronary artery bypass grafting.

  7. we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11 (show GNA11 Proteins), and EIF1AX (show EIF1AX Proteins) mutations.

  8. Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha)

  9. GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.

  10. Results found that GNAQ was highly expressed in gastric cancer (GC) patient samples and suggest that GNAQ plays a critical role in regulating GC cell growth and survival via canonical oncogenic signaling pathways including MAPK (show MAPK1 Proteins) and p53 (show TP53 Proteins).

Pig (Porcine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. The Galphas (show GNAS Proteins) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq peptide interactions are predominantly hydrophobic.

  2. The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. atomic structure of GRK2 (show ADRBK1 Proteins) in complex with Galphaq and Gbetagamma, in which the activated Galpha (show SUCLG1 Proteins) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (show HAND1 Proteins) differentiation

  2. Fluid shear stress acts on the Galphaq-ERK5 (show MAPK7 Proteins) signaling pathway to upregulate Cyclin B1 (show CCNB1 Proteins) and CDK1 (show CDK1 Proteins) expression, thereby resulting in MC3T3-E1 cell proliferation.

  3. activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (show CRH Proteins) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission

  4. cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.

  5. The Galphas (show GNAS Proteins) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq peptide interactions are predominantly hydrophobic.

  6. the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.

  7. The betaARKrgs peptide, but not endogenous GRK2 (show ADRBK1 Proteins), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (show ADRBK1 Proteins)-based therapeutic approaches to prevent hypertrophy and heart failure.

  8. Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.

  9. Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life.

  10. demonstrate that the ability of an MC4R (show MC4R Proteins) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

GNAQ Protein Profile

Protein Summary

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

Alternative names and synonyms associated with GNAQ

  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (GNAQ)
  • guanine nucleotide binding protein (G protein), q polypeptide (Gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq-b)
  • guanine nucleotide binding protein, alpha q polypeptide (Gnaq)
  • 1110005L02Rik protein
  • 6230401I02Rik protein
  • AA408290 protein
  • AW060788 protein
  • CMC1 protein
  • Dsk1 protein
  • Dsk10 protein
  • g-alpha-q protein
  • Galphaq protein
  • gaq protein
  • Gnaq protein
  • gnaqb protein
  • Gq protein
  • GqI protein
  • si:ch73-270f14.2 protein
  • SWS protein

Protein level used designations for GNAQ

Galpha q , gnaqa , guanine nucleotide-binding protein G(q) subunit alpha , guanine nucleotide-binding protein alpha-q , G alpha q , guanine nucleotide binding protein alpha q subunit , guanine nucleotide binding protein, alpha q polypeptide , guanine nucleotide regulatory protein G alpha q , heterotrimeric guanine nucleotide-binding protein alpha q subunit , guanine nucleotide-binding protein G(q) alpha subunit

GENE ID SPECIES
570108 Danio rerio
2776 Homo sapiens
403928 Canis lupus familiaris
81666 Rattus norvegicus
427262 Gallus gallus
654405 Sus scrofa
536654 Bos taurus
399261 Xenopus laevis
14682 Mus musculus
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