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Phospholipase C beta connects G protein signaling with RNA interference. (Review)
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (show SOX10 Proteins) expression and presence of the BRAF (show BRAF Proteins) V600E mutation.
Mutations in GNAQ and GNA11 (show GNA11 Proteins) genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
These results indicate that the mechanism by which Galphaq and PLC (show HSPG2 Proteins)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
Data (including data from studies using cells from knockout mice) suggest that CLEC2 (show CLEC1B Proteins)/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 (show CLEC1B Proteins) = C-type lectin (show MBL2 Proteins) CLEC2 (show CLEC1B Proteins); CLEC2R = CLEC2 (show CLEC1B Proteins) receptor; GNAQ = guanine nucleotide-binding protein (show COASY Proteins) G[q] subunit alpha)
The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b (show CCR2 Proteins)-stimulated Rho A (show RHOA Proteins) GTPase (show RACGAP1 Proteins)-mediated serum response factor activation.
GNAQ/11 mutant clones make up a fraction of the cells in choroidal nevi. Nevus cells are furthermore characterised by heterogeneous YAP (show YAP1 Proteins) expression. Combined GNAQ/11 and YAP (show YAP1 Proteins) may constitute a putative precursor tumour pathway with an activated oncogene (show RAB1A Proteins) (GNAQ/11) and downstream effector (YAP (show YAP1 Proteins)).
RasGRP3 (show RASGRP3 Proteins) mediates ERK MAPK (show MAPK1 Proteins) pathway activation in GNAQ mutant uveal melanoma.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (show TH1L Proteins) differentiation
The GC/GC (show GC Proteins) genotype of the TT(-695/-694)GC polymorphism is associated with increased Gq protein expression, augmented angiotensin II receptor type 1 (show AGTR1 Proteins)-related vasoconstriction, and increased myocardial injury after coronary artery bypass grafting.
The Galphas (show GNAS Proteins) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (show ADRBK1 Proteins) in complex with Galphaq and Gbetagamma, in which the activated Galpha (show SUCLG1 Proteins) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (show TGFB1 Proteins) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (show IL33 Proteins) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the impaired working memory in forebrain-specific Perk (show EIF2AK3 Proteins) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (show CA2 Proteins)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (show HAND1 Proteins) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (show MAPK7 Proteins) signaling pathway to upregulate Cyclin B1 (show CCNB1 Proteins) and CDK1 (show CDK1 Proteins) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (show CRH Proteins) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
The betaARKrgs peptide, but not endogenous GRK2 (show ADRBK1 Proteins), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (show ADRBK1 Proteins)-based therapeutic approaches to prevent hypertrophy and heart failure.
Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit