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Browse our GNAQ Proteins (GNAQ)

Full name:
Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide Proteins (GNAQ)
On www.antibodies-online.com are 13 Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Proteins from 4 different suppliers available. Additionally we are shipping GNAQ Antibodies (82) and GNAQ Kits (1) and many more products for this protein. A total of 104 GNAQ products are currently listed.
Synonyms:
1110005L02Rik, 6230401I02Rik, AA408290, AW060788, CMC1, Dsk1, Dsk10, g-alpha-q, Galphaq, gaq, Gnaq, gnaqb, Gq, GqI, si:ch73-270f14.2, SWS
list all proteins Gene Name GeneID UniProt
GNAQ 2776 P50148
GNAQ 81666 P82471
GNAQ 14682 P21279

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GNAQ Proteins (GNAQ) by Origin

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More Proteins for GNAQ Interaction Partners

Human Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs.

  2. CGRP (show S100A12 Proteins) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS Proteins), Galphai, and Galphaq/11 pathways.

  3. The Galphas (show GNAS Proteins) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq peptide interactions are predominantly hydrophobic.

  4. Data show that GNAQ promotes ARF6 (show ARF6 Proteins) activation to control the proliferation of Uveal Melanoma Cells.

  5. Driver mutations are rare in mutational hotspots of BRAF (show BRAF Proteins), NRAS (show NRAS Proteins), KIT, and GNAQ/GNA11 (show GNA11 Proteins) in oral mucosal melanoma.

  6. data suggest that the interaction between this novel region in Galphaq and the effector PKCzeta (show PRKCZ Proteins) is a key event in Galphaq signaling.

  7. The Glu209 GNAQ and GNA11 (show GNA11 Proteins) missense variants we identified are common in uveal melanoma and have been shown to constitutively activate MAPK (show MAPK1 Proteins) and/or YAP (show YAP1 Proteins) signaling. Our data indicate that chorangioma is probably not the placental counterpart of congenital hemangiomas associated with mutations altering Gln209 in GNAQ or GNA11 (show GNA11 Proteins).

  8. findings demonstrate that hNPS-(1-10) is a biased agonist favoring Galphaq-dependent signaling. It may represent a valuable chemical probe for further investigation of the therapeutic potential of human NPS (show NPS Proteins) receptor-directed signalingin vivo.

  9. extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 (show GNA11 Proteins) and GNAQ, genes that encode Galpha (show SUCLG1 Proteins) subunits of heterotrimeric G proteins

  10. Galphaq expression was negatively associated with interleukin-17A expression in RA patients, indicating that Galphaq ne (show MAPK3 Proteins)gatively controlled the differentiati (show STAT3 Proteins)on of Th17 cells.

Pig (Porcine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. The Galphas (show GNAS Proteins) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq peptide interactions are predominantly hydrophobic.

  2. The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. atomic structure of GRK2 (show ADRBK1 Proteins) in complex with Galphaq and Gbetagamma, in which the activated Galpha (show SUCLG1 Proteins) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.

  2. The Galphas (show GNAS Proteins) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq peptide interactions are predominantly hydrophobic.

  3. the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.

  4. The betaARKrgs peptide, but not endogenous GRK2 (show ADRBK1 Proteins), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (show ADRBK1 Proteins)-based therapeutic approaches to prevent hypertrophy and heart failure.

  5. Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.

  6. Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life.

  7. demonstrate that the ability of an MC4R (show MC4R Proteins) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

  8. In studies with Gnaq(-/-) mice, Galphaq inhibited the differentiation of Th17 cell via regulating the activity of ERK-1 (show MAPK3 Proteins)/2 to control the expression of STAT3 (show STAT3 Proteins) and RORalpha.

  9. the conditional deletion of Galphaq/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.

  10. Gnaq was selectively inactivated in GnRH (show GNRH1 Proteins) neurons of global Gna11 (show GNA11 Proteins)--null mice. Galphaq/11-coupled signaling is a major conduit of GnRH (show GNRH1 Proteins) secretion, results with these mice showed a role for non-Galphaq/11-coupled signaling in reproductive development and function.

GNAQ Protein Profile

Protein Summary

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

Alternative names and synonyms associated with GNAQ

  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (GNAQ)
  • guanine nucleotide binding protein (G protein), q polypeptide (Gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq-b)
  • guanine nucleotide binding protein, alpha q polypeptide (Gnaq)
  • 1110005L02Rik protein
  • 6230401I02Rik protein
  • AA408290 protein
  • AW060788 protein
  • CMC1 protein
  • Dsk1 protein
  • Dsk10 protein
  • g-alpha-q protein
  • Galphaq protein
  • gaq protein
  • Gnaq protein
  • gnaqb protein
  • Gq protein
  • GqI protein
  • si:ch73-270f14.2 protein
  • SWS protein

Protein level used designations for GNAQ

Galpha q , gnaqa , guanine nucleotide-binding protein G(q) subunit alpha , guanine nucleotide-binding protein alpha-q , G alpha q , guanine nucleotide binding protein alpha q subunit , guanine nucleotide binding protein, alpha q polypeptide , guanine nucleotide regulatory protein G alpha q , heterotrimeric guanine nucleotide-binding protein alpha q subunit , guanine nucleotide-binding protein G(q) alpha subunit

GENE ID SPECIES
570108 Danio rerio
2776 Homo sapiens
403928 Canis lupus familiaris
81666 Rattus norvegicus
427262 Gallus gallus
654405 Sus scrofa
536654 Bos taurus
399261 Xenopus laevis
14682 Mus musculus
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