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Browse our GNAQ Proteins (GNAQ)

Full name:
Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide Proteins (GNAQ)
On are 12 Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Proteins from 3 different suppliers available. Additionally we are shipping GNAQ Antibodies (73) and GNAQ Kits (1) and many more products for this protein. A total of 94 GNAQ products are currently listed.
1110005L02Rik, 6230401I02Rik, AA408290, AW060788, CMC1, Dsk1, Dsk10, g-alpha-q, Galphaq, gaq, Gnaq, gnaqb, Gq, GqI, si:ch73-270f14.2, SWS
list all proteins Gene Name GeneID UniProt
GNAQ 2776 P50148
GNAQ 81666 P82471
GNAQ 14682 P21279

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GNAQ Proteins (GNAQ) by Origin

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More Proteins for GNAQ Interaction Partners

Human Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. The Glu209 GNAQ and GNA11 (show GNA11 Proteins) missense variants we identified are common in uveal melanoma and have been shown to constitutively activate MAPK (show MAPK1 Proteins) and/or YAP (show YAP1 Proteins) signaling. Our data indicate that chorangioma is probably not the placental counterpart of congenital hemangiomas associated with mutations altering Gln209 in GNAQ or GNA11 (show GNA11 Proteins).

  2. findings demonstrate that hNPS-(1-10) is a biased agonist favoring Galphaq-dependent signaling. It may represent a valuable chemical probe for further investigation of the therapeutic potential of human NPS (show NPS Proteins) receptor-directed signalingin vivo.

  3. extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 (show GNA11 Proteins) and GNAQ, genes that encode Galpha (show SUCLG1 Proteins) subunits of heterotrimeric G proteins

  4. Galphaq expression was negatively associated with interleukin-17A expression in RA patients, indicating that Galphaq ne (show MAPK3 Proteins)gatively controlled the differentiati (show STAT3 Proteins)on of Th17 cells.

  5. We conclude that enrichment of GNAQ (R183Q) in port-wine stain (PWS) blood vessels may induce consecutive activation of c-Jun (show JUN Proteins) N-terminal kinases and extracellular signal regulated kinases, thus contributing to the pathogenesis of PWS.

  6. Distribution of GNAQ and GNA11 (show GNA11 Proteins) Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.

  7. This is the second largest study on isolated, non-syndromic Port-wine stain; data suggest that GNAQ is the main genetic determinant in this condition. Moreover, isolated port-wine stains are distinct from capillary malformations seen in RASA1 (show RASA1 Proteins) disorders.

  8. The results suggested that GNAQ mutation induced viability and migration of uveal melanoma cells via Notch (show NOTCH1 Proteins) signaling activation, which is mediated by YAP (show YAP1 Proteins) dephosphorylation and nuclear translocation.

  9. This study demonstrated that the GNAQ protein was reduced in auditory cortex patient with schizophreia.

  10. Oncogenic GNAQ mutation is associated with uveal melanoma.

Pig (Porcine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. atomic structure of GRK2 (show ADRBK1 Proteins) in complex with Galphaq and Gbetagamma, in which the activated Galpha (show SUCLG1 Proteins) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) interaction partners

  1. Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.

  2. Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life.

  3. demonstrate that the ability of an MC4R (show MC4R Proteins) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

  4. In studies with Gnaq(-/-) mice, Galphaq inhibited the differentiation of Th17 cell via regulating the activity of ERK-1 (show MAPK3 Proteins)/2 to control the expression of STAT3 (show STAT3 Proteins) and RORalpha.

  5. the conditional deletion of Galphaq/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.

  6. Gnaq was selectively inactivated in GnRH (show GNRH1 Proteins) neurons of global Gna11 (show GNA11 Proteins)--null mice. Galphaq/11-coupled signaling is a major conduit of GnRH (show GNRH1 Proteins) secretion, results with these mice showed a role for non-Galphaq/11-coupled signaling in reproductive development and function.

  7. Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (show RIC8A Proteins)) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 Proteins) alpha subunits Galphai2 (show GNAI2 Proteins), Galphai3 (show GNAI3 Proteins), and Galphaq.

  8. Data show that the expression of the guanine nucleotide binding protein alpha q GNAQ(Q209L) allele induced causes the rapid development of uveal melanoma, with local invasion of blood vessels and multiple tumors developing in the lungs.

  9. Fluorosed mouse ameloblasts have increased SATB1 (show SATB1 Proteins) retention and Galphaq activity.

  10. Vasoconstriction and hypertension is modulated by endocannabinoid-induced Galphaq11-CB1 cannabinoid receptor (show CNR1 Proteins) signaling.

GNAQ Protein Profile

Protein Summary

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

Alternative names and synonyms associated with GNAQ

  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (GNAQ)
  • guanine nucleotide binding protein (G protein), q polypeptide (Gnaq)
  • guanine nucleotide binding protein (G protein), q polypeptide (gnaq-b)
  • guanine nucleotide binding protein, alpha q polypeptide (Gnaq)
  • 1110005L02Rik protein
  • 6230401I02Rik protein
  • AA408290 protein
  • AW060788 protein
  • CMC1 protein
  • Dsk1 protein
  • Dsk10 protein
  • g-alpha-q protein
  • Galphaq protein
  • gaq protein
  • Gnaq protein
  • gnaqb protein
  • Gq protein
  • GqI protein
  • si:ch73-270f14.2 protein
  • SWS protein

Protein level used designations for GNAQ

Galpha q , gnaqa , guanine nucleotide-binding protein G(q) subunit alpha , guanine nucleotide-binding protein alpha-q , G alpha q , guanine nucleotide binding protein alpha q subunit , guanine nucleotide binding protein, alpha q polypeptide , guanine nucleotide regulatory protein G alpha q , heterotrimeric guanine nucleotide-binding protein alpha q subunit , guanine nucleotide-binding protein G(q) alpha subunit

570108 Danio rerio
2776 Homo sapiens
403928 Canis lupus familiaris
81666 Rattus norvegicus
427262 Gallus gallus
654405 Sus scrofa
536654 Bos taurus
399261 Xenopus laevis
14682 Mus musculus
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