Browse our IL-6 Receptor Proteins (IL6R)

Full name:
Interleukin-6 Receptor Proteins (IL6R)
On www.antibodies-online.com are 50 Interleukin-6 Receptor (IL6R) Proteins from 14 different suppliers available. Additionally we are shipping IL-6 Receptor Antibodies (301) and IL-6 Receptor Kits (59) and many more products for this protein. A total of 428 IL-6 Receptor products are currently listed.
Synonyms:
CD126, gp80, IL-6R, IL-6R-1, IL-6RA, IL-6Ralpha, IL6Q, Il6r, IL6R1, Il6ra, IL6RQ
list all proteins Gene Name GeneID UniProt
IL6R 3570 P08887
IL6R 24499  
IL6R 16194 P22272

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IL-6 Receptor Proteins (IL6R) by Origin

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Top referenced IL-6 Receptor Proteins

  1. Human IL-6 Receptor Protein expressed in Human Cells - ABIN2002777 : Yamasaki, Taga, Hirata, Yawata, Kawanishi, Seed, Taniguchi, Hirano, Kishimoto: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. in Science (New York, N.Y.) 1988 (PubMed)
    Show all 5 references for 2002777

  2. Mouse (Murine) IL-6 Receptor Protein expressed in Human Cells - ABIN2007611 : Müller-Newen, Küster, Hemmann, Keul, Horsten, Martens, Graeve, Wijdenes, Heinrich: Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 5 references for 2007611

  3. Rat (Rattus) IL-6 Receptor Protein expressed in Human Cells - ABIN2009668 : Ancey, Küster, Haan, Herrmann, Heinrich, Müller-Newen: A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for 2009668

  4. Human IL-6 Receptor Protein expressed in HEK-293 Cells - ABIN2181394 : Yoshio-Hoshino, Adachi, Aoki, Pereboev, Curiel, Nishimoto: Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor. in Cancer research 2007 (PubMed)
    Show all 2 references for 2181394

More Proteins for IL-6 Receptor Interaction Partners

Zebrafish Interleukin-6 Receptor (IL6R) interaction partners

  1. The expression of IL-6 (show IL6 PLURAL_@42467@), IL-6R and gp130 (show IL6ST PLURAL_@42467@) transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.

Human Interleukin-6 Receptor (IL6R) interaction partners

  1. Data show that the let-7c/miR (show MLXIP Proteins)-99a/miR (show MLXIP Proteins)-125b cluster controlled tumorigenesis by targeting IL-6 (show IL6 Proteins), IL-6R and IGF1R (show IGF1R Proteins).

  2. Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf (show MAF Proteins) induction were adverse events for counteracting tumor-specific Th1 (show TH1L Proteins) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy

  3. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 (show ADAM17 Proteins) in regulating murine IL-6 (show IL6 Proteins) signals during inflammatory processes.

  4. this study show that soluble IL-6R is infiltrating from the circulation in an ADAM17 (show ADAM17 Proteins)-independent process and is involved in the controlled resolution of an acute inflammatory episode

  5. the sIL (show PMEL Proteins)-6R/p28 (show PSMD10 Proteins) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (show AFT1 Proteins) to the IFN-lambda1 promoter via the p38 MAPK (show MAPK14 Proteins) signaling pathway; results demonstrate the important role of sIL (show PMEL Proteins)-6R/p28 (show PSMD10 Proteins) FP in mediating virus-induced type III IFN production

  6. Thus, trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5.

  7. The here presented data demonstrate that miR (show MLXIP Proteins)-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in osteosarcoma via down-regulating IL 6R.

  8. DNA hypomethylation of IL-6 (show IL6 Proteins) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.

  9. DNA hypomethylation of IL-6 (show IL6 Proteins) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.

  10. minor allele, with the difference eliminated upon addition of tocilizumab. In conclusion, there is evidence that neutrophils may be an important source of sIL-6R in the lungs, and the Asp358Ala variant may have pro-inflammatory effects in lung cells.d However, we were unable to identify evidence for aisease

Pig (Porcine) Interleukin-6 Receptor (IL6R) interaction partners

  1. IL-6sR and gp130 (show ANPEP PLURAL_@42467@), but not IL-6R alpha, play important roles in regulation of granulosa cell survival

Cow (Bovine) Interleukin-6 Receptor (IL6R) interaction partners

  1. Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6 (show IL6 Proteins)/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.

Mouse (Murine) Interleukin-6 Receptor (IL6R) interaction partners

  1. TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Proteins), DNAX-activation protein 12 (show TYROBP Proteins), and cell proliferation

  2. C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 (show LRPPRC PLURAL_@42467@) expression following lipoic acid treatment or heat shock.

  3. Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus

  4. findings identify TRAF3 (show TRAF3 Proteins) and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Proteins) in the regulation of plasma cell differentiation

  5. Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Proteins)) and inhibit the bone loss they cause.

  6. established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Proteins) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Proteins)

  7. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung

  8. When endogenously released IL-6 (show IL6 Proteins) binds to Il-6Ralpha in brain the effect is pyrogenic.

  9. metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 Proteins) as well as soluble IL-6Ra, which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.

  10. Cellular senescence or EGFR (show EGFR Proteins) signaling induces Interleukin 6 receptor expression controlled by mTOR (show FRAP1 Proteins).

IL-6 Receptor (IL6R) Protein Profile

Protein Summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Alternative names and synonyms associated with IL-6 Receptor (IL6R)

  • interleukin 6 receptor (IL6R)
  • interleukin 6 receptor (il6r)
  • interleukin 6 receptor (Il6r)
  • interleukin 6 receptor-like (LOC100347752)
  • interleukin 6 receptor, alpha (Il6ra)
  • CD126 protein
  • gp80 protein
  • IL-6R protein
  • IL-6R-1 protein
  • IL-6RA protein
  • IL-6Ralpha protein
  • IL6Q protein
  • Il6r protein
  • IL6R1 protein
  • Il6ra protein
  • IL6RQ protein

Protein level used designations for Interleukin-6 Receptor Proteins (IL6R)

interleukin 6 receptor , interleukin 6 receptor alpha , interleukin-6 receptor subunit alpha , CD126 antigen , IL-6 receptor subunit alpha , IL-6R 1 , membrane glycoprotein 80 , IL-6R subunit alpha , IL-6R-alpha , IL-6RA , interleukin 6 receptor, alpha , IL-6 receptor alpha chain

GENE ID SPECIES
469506 Pan troglodytes
100135755 Danio rerio
3570 Homo sapiens
24499 Rattus norvegicus
101085689 Felis catus
399522 Sus scrofa
612271 Canis lupus familiaris
507359 Bos taurus
100730490 Cavia porcellus
101103369 Ovis aries
100347752 Oryctolagus cuniculus
16194 Mus musculus
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