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Browse our IL-6 Receptor Proteins (IL6R)

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Interleukin-6 Receptor Proteins (IL6R)
On are 56 Interleukin-6 Receptor (IL6R) Proteins from 15 different suppliers available. Additionally we are shipping IL-6 Receptor Antibodies (273) and IL-6 Receptor Kits (60) and many more products for this protein. A total of 407 IL-6 Receptor products are currently listed.
CD126, gp80, IL-6R, IL-6R-1, IL-6RA, IL-6Ralpha, IL6Q, Il6r, IL6R1, Il6ra, IL6RQ
list all proteins Gene Name GeneID UniProt
IL6R 3570 P08887
IL6R 24499  
IL6R 16194 P22272

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IL-6 Receptor Proteins (IL6R) by Origin

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Top referenced IL-6 Receptor Proteins

  1. Human IL-6 Receptor Protein expressed in Human Cells - ABIN2002777 : Yamasaki, Taga, Hirata, Yawata, Kawanishi, Seed, Taniguchi, Hirano, Kishimoto: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. in Science (New York, N.Y.) 1988 (PubMed)
    Show all 5 references for ABIN2002777

  2. Mouse (Murine) IL-6 Receptor Protein expressed in Human Cells - ABIN2007611 : Müller-Newen, Küster, Hemmann, Keul, Horsten, Martens, Graeve, Wijdenes, Heinrich: Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 5 references for ABIN2007611

  3. Rat (Rattus) IL-6 Receptor Protein expressed in Human Cells - ABIN2009668 : Ancey, Küster, Haan, Herrmann, Heinrich, Müller-Newen: A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN2009668

  4. Human IL-6 Receptor Protein expressed in HEK-293 Cells - ABIN2181394 : Yoshio-Hoshino, Adachi, Aoki, Pereboev, Curiel, Nishimoto: Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor. in Cancer research 2007 (PubMed)
    Show all 2 references for ABIN2181394

More Proteins for IL-6 Receptor Interaction Partners

Zebrafish Interleukin-6 Receptor (IL6R) interaction partners

  1. The expression of IL-6 (show IL6 Proteins), IL-6R and gp130 (show IL6ST Proteins) transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.

Human Interleukin-6 Receptor (IL6R) interaction partners

  1. Thus, trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5.

  2. The here presented data demonstrate that miR (show MLXIP Proteins)-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in osteosarcoma via down-regulating IL 6R.

  3. DNA hypomethylation of IL-6 (show IL6 Proteins) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.

  4. DNA hypomethylation of IL-6 (show IL6 Proteins) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.

  5. minor allele, with the difference eliminated upon addition of tocilizumab. In conclusion, there is evidence that neutrophils may be an important source of sIL-6R in the lungs, and the Asp358Ala variant may have pro-inflammatory effects in lung cells.d However, we were unable to identify evidence for aisease

  6. Data indicate possible associations between pretransplant levels of CRP (show CRP Proteins)/IL-6 /IL-6 (show IL6 Proteins) receptor /gp130 (show IL6ST Proteins) and posttransplant outcomes.

  7. MiR-451 may function as a potential suppressor of tumor angiogenesis in HCC by targeting IL-6R-STAT3-VEGF signaling, suggesting.

  8. miR-106a promoted the growth and invasion of SKOV3 cells by targeting phosphatase and tensin homolog (PTEN). Furthermore, the present study revealed that IL-6 inhibited miR-106a expression by activating STAT3. Tocilizumab, a humanized anti-human IL-6R antibody, that competitively inhibits IL-6/IL-6R signaling, did not inhibit the proliferation and invasion of SKOV3 cells.

  9. No significant association between IL6R rs2228145 and dementia.

  10. we evaluated anti-IL-6 (show IL6 Proteins) receptor antibody treatment of cancer-related anemia in an IL-6 (show IL6 Proteins)-producing human lung cancer xenograft model.We demonstrated that inhibition of the IL-6 (show IL6 Proteins) signaling pathway by MR16-1 treatment resulted in significant recovery of iron-deficiency anemia and alleviation of cancer-related symptoms

Pig (Porcine) Interleukin-6 Receptor (IL6R) interaction partners

  1. IL-6sR and gp130 (show ANPEP Proteins), but not IL-6R alpha, play important roles in regulation of granulosa cell survival

Cow (Bovine) Interleukin-6 Receptor (IL6R) interaction partners

  1. Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6 (show IL6 Proteins)/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.

Mouse (Murine) Interleukin-6 Receptor (IL6R) interaction partners

  1. C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 (show LRPPRC Proteins) expression following lipoic acid treatment or heat shock.

  2. Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus

  3. findings identify TRAF3 (show TRAF3 Proteins) and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Proteins) in the regulation of plasma cell differentiation

  4. Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Proteins)) and inhibit the bone loss they cause.

  5. established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Proteins) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Proteins)

  6. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung

  7. When endogenously released IL-6 (show IL6 Proteins) binds to Il-6Ralpha in brain the effect is pyrogenic.

  8. metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 Proteins) as well as soluble IL-6Ra, which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.

  9. Cellular senescence or EGFR (show EGFR Proteins) signaling induces Interleukin 6 receptor expression controlled by mTOR (show FRAP1 Proteins).

  10. IL-6Ralpha deficiency activates PP-1alpha and Mule expression, resulting in increased Mcl-1 (show MCL1 Proteins) turnover and protection against HCC (show FAM126A Proteins) development.

IL-6 Receptor (IL6R) Protein Profile

Protein Summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Alternative names and synonyms associated with IL-6 Receptor (IL6R)

  • interleukin 6 receptor (IL6R)
  • interleukin 6 receptor (il6r)
  • interleukin 6 receptor (Il6r)
  • interleukin 6 receptor-like (LOC100347752)
  • interleukin 6 receptor, alpha (Il6ra)
  • CD126 protein
  • gp80 protein
  • IL-6R protein
  • IL-6R-1 protein
  • IL-6RA protein
  • IL-6Ralpha protein
  • IL6Q protein
  • Il6r protein
  • IL6R1 protein
  • Il6ra protein
  • IL6RQ protein

Protein level used designations for Interleukin-6 Receptor Proteins (IL6R)

interleukin 6 receptor , interleukin 6 receptor alpha , interleukin-6 receptor subunit alpha , CD126 antigen , IL-6 receptor subunit alpha , IL-6R 1 , membrane glycoprotein 80 , IL-6R subunit alpha , IL-6R-alpha , IL-6RA , interleukin 6 receptor, alpha , IL-6 receptor alpha chain

469506 Pan troglodytes
100135755 Danio rerio
3570 Homo sapiens
24499 Rattus norvegicus
101085689 Felis catus
399522 Sus scrofa
612271 Canis lupus familiaris
507359 Bos taurus
100730490 Cavia porcellus
101103369 Ovis aries
100347752 Oryctolagus cuniculus
16194 Mus musculus
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