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IL21R is probably not causally involved in recurrent airway obstruction.
bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14 (show NDUFA2 Proteins)(+) cells in enhanced osteoclast formation.
Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals.
expression of IL-21 (show IL17C Proteins) and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade
interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency (show PRKDC Proteins).
IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE.
IL-21 (show IL17C Proteins)/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity.
STAT3 (show STAT3 Proteins) signaling downstream of IL-23R (show IL23R Proteins) and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT (show SLC22A6 Proteins) cell numbers
Human neutrophils in peripheral blood express functional IL-21 (show IL17C Proteins) receptors.
IL-21R gene polymorphisms and serum IL-21 (show IL17C Proteins) levels predict virological response to interferon (show IFNA Proteins)-based therapy in Asian chronic hepatitis C patients.
Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease.
this study shows that IL-21R signaling is essential for the optimal control of Mycobacterium tuberculosis infection
natural genetic variation in murine Il21r influences neuronal cell viability after ischemia by modulating receptor function and downstream signal transduction
IL-21 (show IL21 Proteins) may play an important role in the pathogenesis of SSc (show CYP11A1 Proteins) as a Th17 effector cytokine, and IL-21 (show IL21 Proteins) may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R.
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21 (show IL21 Proteins), IL21R, and a series of genes associated with TFH cell development and function.
IIl21r deletion reduced spontaneous EAE associated with defective Th17 cell generation. IL-21R deficiency limited IL-23R (show IL23R Proteins) expression on Th17 cells and inhibited expression of key molecules for pathogenic Th17 cell generation.
our data demonstrate the novel finding that the IL-21R plays a critical role in regulating innate immune responses against HSV-2 infection.
During experimental arthritis, IL-21R deficiency protected against severe inflammation and joint destruction. This was accompanied by suppressed serum IgG1 levels and antigen-specific T cell responses.
in the absence of IL-21 (show IL21 Proteins)/IL-21R signaling, Il2 (show IL2 Proteins)(-/-) mice retained a deficiency in Tregs yet exhibited a reduced and delayed inflammatory disease which was reflected in reduced pancreatitis and hemolytic anemia
IL-21R expression on donor CD4 (show CD4 Proteins)+ T cells is essential for sustaining T cell number and help for B cells, resulting in more severe lupus-like renal disease, but it does not alter the balance of T helper (Th)17 cells and regulatory T cells.
IL-21R controls both antigen transport by DCs and the crucial beacon (show UBL5 Proteins) function of CD4 (show CD4 Proteins)(+) cells for autoreactive CD8 (show CD8A Proteins)(+) cells to reach the islets.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
, interleukin 21 receptor
, interleukin 21 receptor alpha.a
, IL-21 receptor
, novel interleukin receptor
, lymphocyte receptor beta
, novel cytokine receptor 8