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Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review
This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema.
This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis.
The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy.
These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients.
The study reports the crystal structure of dimeric IL-5 (show IL5 Proteins) in complex with the IL5RA extracellular domains.
REVIEW: Interleukin-5 (show IL5 Proteins) and IL-5 (show IL5 Proteins) receptor in health and disease
we determined the structure of IL-5 (show IL5 Proteins) bound to the extracellular domain of IL-5Ralpha.
Polymorphisms in IL5RA, LPL (show LCP1 Proteins), ITGA2 (show ITGA2 Proteins) and NOS3 (show NANOS3 Proteins) genes were independently associated with ischemic stroke in Chinese diabetic population.
findings are consistent with an airway tissue-selective expression of the IL-5 (show IL5 Proteins) receptor that mediates IL-5 (show IL5 Proteins)-induced airway hyperresponsiveness independent of eosinophils
SLy2 (show SAMSN1 Proteins) controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.
Interleukin-5 receptor alpha chain expression and splicing during brain development in mice.
IL-5 (show IL5 Proteins) is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 (show IL5 Proteins) gene (show GPD1 Proteins)-deleted mice
Octamer Transcription Factor 2 (show HNF1B Proteins) (Oct2 (show SLC22A2 Proteins)) augments the ability of activated B cells to differentiate to antibody-secreting plasma cells under T cell-dependent conditions through regulation of the gene encoding the interleukin 5 receptor alpha chain.
We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver
The murine interleukin-5 receptor alpha chain pre-mRNA is alternatively spliced, resulting in soluble isoforms lacking the transmembrane coding region which do not complex with the IL-5R beta chain.
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.
interleukin 5 receptor, alpha
, Interleukin-5 receptor subunit alpha
, interleukin-5 receptor subunit alpha
, interleukin 5 receptor alpha
, interleukin-5 receptor, alpha
, interleukin-5 receptor subunit alpha-like
, CD125 antigen
, IL-5 receptor subunit alpha
, IL-5R subunit alpha
, interleukin 5 receptor type 3
, interleukin-5 receptor alpha chain
, IL-5 receptor alpha chain