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anti-Mouse (Murine) IL6RA Antibodies:
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This is the first study to investigate the effects of functional two polymorphisms on IL-6 (show IL6 Antibodies) and IL-6R genes in a pediatric patient group with AA risk.
results provide evidence that two IL6R gene polymorphisms rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma. Furthermore, the rs2228145 A-C variant is associated with levels of sIL-6R and IgE.
miR (show MLXIP Antibodies)-125a-5p directly targets IL-6R and STAT3 (show STAT3 Antibodies) expression in HEK (show EPHA3 Antibodies)-293T cells.
findings identify TRAF3 (show TRAF3 Antibodies) and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Antibodies) in the regulation of plasma cell differentiation
Interleukin-6 (show IL6 Antibodies) is strongly affected by factors associated with obesity accounting for its lability and responsiveness to diet, life style and contemporaneous events.
soluble IL-6R expression upregulated the levels of its own ligand, IL-6 (show IL6 Antibodies) and those of the pro-inflammatory cytokine IL-32 (show IL32 Antibodies).
The serum levels of VEGF (show VEGFA Antibodies), IL-17 (show IL17A Antibodies), IL-10 (show IL10 Antibodies) and TNF-alpha (show TNF Antibodies) were lower in the pregnant women with PE when compared with their normotensive peers, while the IL-6 (show IL6 Antibodies) levels were higher
In obese children and adolescents, insulin (show INS Antibodies) resistance is associated with elevated levels of IL-6 (show IL6 Antibodies) and diminished values of sIL (show PMEL Antibodies)-6R.
obesity was a positive modulator of IL-6R and IL-6 (show IL6 Antibodies) expression in the adipose tissue which might be a contributory mechanism to induce metabolic inflammation.
It was predicted that interleukin-6-receptor (IL6R (show IL6R Antibodies)) was a potential target gene of miR (show MLXIP Antibodies)-34a by bioinformatics analysis and identified by luciferase assay. It was further showed that miR (show MLXIP Antibodies)-34a inhibited oral cancer progression via IL6R (show IL6R Antibodies)
Data show that blockade of interleukin-6 receptor (show IL6R Antibodies) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Antibodies)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Antibodies) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Antibodies)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 Antibodies) binds to Il-6Ralpha (show IL6R Antibodies) in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 Antibodies) as well as soluble IL-6Ra (show IL6R Antibodies), which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (show EGFR Antibodies) signaling induces Interleukin 6 receptor (show IL6R Antibodies) expression controlled by mTOR (show FRAP1 Antibodies).
IL-6Ralpha (show IL6R Antibodies) deficiency activates PP-1alpha and Mule expression, resulting in increased Mcl-1 (show MCL1 Antibodies) turnover and protection against HCC (show FAM126A Antibodies) development.
identify the transcription factor Twist1 (show TWIST1 Antibodies) as a component of a STAT3 (show STAT3 Antibodies)-induced feedback loop that controls IL-6 (show IL6 Antibodies) signals by directly repressing Il6ra (show IL6R Antibodies).
a dual role of the IL-6R stalk region in IL-6 (show IL6 Antibodies) signaling.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain