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anti-Human IL6RA Antibodies:
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Data show that the let-7c/miR (show MLXIP Antibodies)-99a/miR (show MLXIP Antibodies)-125b cluster controlled tumorigenesis by targeting IL-6 (show IL6 Antibodies), IL-6R and IGF1R (show IGF1R Antibodies).
Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf (show MAF Antibodies) induction were adverse events for counteracting tumor-specific Th1 (show TH1L Antibodies) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 (show ADAM17 Antibodies) in regulating murine IL-6 (show IL6 Antibodies) signals during inflammatory processes.
this study show that soluble IL-6R is infiltrating from the circulation in an ADAM17 (show ADAM17 Antibodies)-independent process and is involved in the controlled resolution of an acute inflammatory episode
the sIL (show PMEL Antibodies)-6R/p28 (show PSMD10 Antibodies) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (show AFT1 Antibodies) to the IFN-lambda1 promoter via the p38 MAPK (show MAPK14 Antibodies) signaling pathway; results demonstrate the important role of sIL (show PMEL Antibodies)-6R/p28 (show PSMD10 Antibodies) FP in mediating virus-induced type III IFN production
Thus, trans-signaling of IL-6 (show IL6 Antibodies) can only occur via sIL (show PMEL Antibodies)-6R, but not sCD5 (show SCD5 Antibodies).
The here presented data demonstrate that miR (show MLXIP Antibodies)-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in osteosarcoma via down-regulating IL 6R.
DNA hypomethylation of IL-6 (show IL6 Antibodies) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.
minor allele, with the difference eliminated upon addition of tocilizumab. In conclusion, there is evidence that neutrophils may be an important source of sIL (show PMEL Antibodies)-6R in the lungs, and the Asp358Ala variant may have pro-inflammatory effects in lung cells.d However, we were unable to identify evidence for aisease
TNF (show TNF Antibodies)/IL-6 (show IL6 Antibodies) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Antibodies), DNAX-activation protein 12 (show TYROBP Antibodies), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha (show IL6R Antibodies) may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Antibodies) and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Antibodies) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor (show IL6R Antibodies) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Antibodies)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Antibodies) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Antibodies)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 Antibodies) binds to Il-6Ralpha (show IL6R Antibodies) in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 Antibodies) as well as soluble IL-6Ra (show IL6R Antibodies), which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (show EGFR Antibodies) signaling induces Interleukin 6 receptor (show IL6R Antibodies) expression controlled by mTOR (show FRAP1 Antibodies).
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain