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anti-Mouse (Murine) IL6RA Antibodies:
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No significant association between IL6R (show IL6R Antibodies) rs2228145 and dementia.
we evaluated anti-IL-6 (show IL6 Antibodies) receptor antibody treatment of cancer-related anemia in an IL-6 (show IL6 Antibodies)-producing human lung cancer xenograft model.We demonstrated that inhibition of the IL-6 (show IL6 Antibodies) signaling pathway by MR16-1 treatment resulted in significant recovery of iron-deficiency anemia and alleviation of cancer-related symptoms
Data suggest domains D1-D3, which contain cytokine binding module, determine which cytokine can activate interleukin-6 (show IL6 Antibodies) or interleukin-11 (show IL11 Antibodies) alpha-receptor subunits; stalk, transmembrane, or intracellular regions do not participate in ligand selectivity.
Anti-IL-6R antibody prevented the early loss of intrahepatic islet grafts mediated by HMGB1 (show HMGB1 Antibodies)-induced immune activation after islet transplantation.
While prior studies have found an association between PDE4D (show PDE4D Antibodies) and IL6R (show IL6R Antibodies) polymorphisms and ischemic stroke, the results of this study suggest that this association may be different in a hypertensive population.
Authors identified miR (show MLXIP Antibodies)-125a as a direct regulator of IL-6R, and the genotype of rs12976445 might be a novel predictor of the development of DN in DM.
This is the first study to investigate the effects of functional two polymorphisms on IL-6 (show IL6 Antibodies) and IL-6R genes in a pediatric patient group with AA risk.
results provide evidence that two IL6R gene polymorphisms rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma. Furthermore, the rs2228145 A-C variant is associated with levels of sIL-6R and IgE.
miR (show MLXIP Antibodies)-125a-5p directly targets IL-6R and STAT3 (show STAT3 Antibodies) expression in HEK (show EPHA3 Antibodies)-293T cells.
findings identify TRAF3 (show TRAF3 Antibodies) and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Antibodies) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor (show IL6R Antibodies) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Antibodies)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Antibodies) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Antibodies)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 Antibodies) binds to Il-6Ralpha (show IL6R Antibodies) in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 Antibodies) as well as soluble IL-6Ra (show IL6R Antibodies), which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (show EGFR Antibodies) signaling induces Interleukin 6 receptor (show IL6R Antibodies) expression controlled by mTOR (show FRAP1 Antibodies).
IL-6Ralpha (show IL6R Antibodies) deficiency activates PP-1alpha and Mule expression, resulting in increased Mcl-1 (show MCL1 Antibodies) turnover and protection against HCC (show FAM126A Antibodies) development.
identify the transcription factor Twist1 (show TWIST1 Antibodies) as a component of a STAT3 (show STAT3 Antibodies)-induced feedback loop that controls IL-6 (show IL6 Antibodies) signals by directly repressing Il6ra (show IL6R Antibodies).
a dual role of the IL-6R stalk region in IL-6 (show IL6 Antibodies) signaling.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain