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This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (show HELLS Proteins) consisting of deactivated Cas9 (dCas9) nuclease (show DCLRE1C Proteins) and catalytic domain of the DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (show HELLS Proteins) of a wider promoter region of the target loci IL6ST and BACH2 (show BACH2 Proteins) decreased their expression
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (show IL6 Proteins) trans-signaling.
Data indicate possible associations between pretransplant levels of CRP (show CRP Proteins)/IL-6 /IL-6 (show IL6 Proteins) receptor /gp130 and posttransplant outcomes.
Soluble glycoprotein 130 and hsp27 (show HSPB1 Proteins) are novel candidate biomarkers for diagnosing Chronic Heart Failure with preserved ejection fraction and thus warrant further investigation; neither dpp4 (show DPP4 Proteins) nor CTSS (show CTSS Proteins) showed promise as biomarkers of Chronic Heart Failure.
Intracellular p19 (show CDKN2D Proteins) associated with the cytokine receptor (show EBI3 Proteins) subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)) signaling
High serum GP130 levels were associated with Chronic Spontaneous Urticaria.
PECs exhibited higher proliferation in response to IL-6 (show IL6 Proteins)/sIL (show PMEL Proteins)-6R co-treatment compared with TECs in HCC (show FAM126A Proteins) via the up-regulation of gp130 /JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins).
Mutations leading to constitutive active gp130/JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) pathway.
In the present study, we analyze the role of a unique cysteine residue (Cys-628) within this C-terminus, which is contained neither in the membrane-bound gp130 nor in the two other sgp130 forms.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
Blocking IL-6 (show IL6 Proteins) trans-signaling in the CNS abrogates the ability of IL-6 (show IL6 Proteins) to suppress feeding. Furthermore, gp130 (show LRPPRC Proteins) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (show LRPPRC Proteins) in the PVH attenuates the beneficial central IL-6 (show IL6 Proteins) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (show LRPPRC Proteins)-dependent STAT3 (show STAT3 Proteins) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6/gp130 signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (show LRPPRC Proteins)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (show INS Proteins) resistance.
differences exist in the expression of receptors utilized by the IL-6 (show IL6 Proteins)/gp130 (show LRPPRC Proteins) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (show OSM Proteins) by astrocytes versus microglia
Deregulation of gp130 (show LRPPRC Proteins)/STAT3 (show STAT3 Proteins) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
IL-6sR and gp130 (show ANPEP Proteins), but not IL-6R alpha (show IL6R Proteins), play important roles in regulation of granulosa cell survival
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
, IL-6 receptor subunit beta
, IL-6R subunit beta
, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
, interleukin receptor beta chain
, interleukin-6 receptor subunit beta
, membrane glycoprotein 130
, membrane glycoprotein gp130
, oncostatin-M receptor subunit alpha
, interleukin-6 signal transducer
, interleukin 6 signal transducer
, glycoprotein 130