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Browse our IL6ST Proteins (IL6ST)

Full name:
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) Proteins (IL6ST)
On are 22 Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Proteins from 5 different suppliers available. Additionally we are shipping IL6ST Antibodies (149) and IL6ST Kits (15) and many more products for this protein. A total of 202 IL6ST products are currently listed.
5133400A03Rik, AA389424, Ac1055, BB405851, CD130, CDW130, D13Ertd699e, GP130, IL-6RB
list all proteins Gene Name GeneID UniProt
IL6ST 16195 Q00560
IL6ST 25205  
IL6ST 3572 P40189

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IL6ST Proteins (IL6ST) by Origin

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More Proteins for IL6ST Interaction Partners

Mouse (Murine) Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) interaction partners

  1. gp130 (show LRPPRC Proteins)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (show INS Proteins) resistance.

  2. differences exist in the expression of receptors utilized by the IL-6 (show IL6 Proteins)/gp130 (show LRPPRC Proteins) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (show OSM Proteins) by astrocytes versus microglia

  3. Deregulation of gp130 (show LRPPRC Proteins)/STAT3 (show STAT3 Proteins) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.

  4. Significant differential expression (both increases and decreases) of multiple IL-6 (show IL6 Proteins)/gp130 (show LRPPRC Proteins) cytokines, such as LIF (show LIF Proteins), oncostatin-M (show OSM Proteins), and ciliary neurotrophic factor (show CNTF Proteins), occurred after Muller cell ablation

  5. GP130 (show LRPPRC Proteins) signaling collaborated with MYC (show MYC Proteins) to induce MM and was responsible and sufficient for directing the plasma cell phenotype.

  6. gp130 (show LRPPRC Proteins), a co-receptor for IL-6 (show IL6 Proteins) cytokines, triggers activation of YAP (show YAP1 Proteins) and Notch (show NOTCH1 Proteins), transcriptional regulators that control tissue growth and regeneration, independently of the gp130 (show LRPPRC Proteins) effector STAT3 (show STAT3 Proteins)

  7. osteocytic gp130 (show LRPPRC Proteins) signaling is required for normal trabecular bone mass and proper cortical bone composition.

  8. PGF2alpha inhibits adipocyte differentiation by means of an IL-11 (show IL11 Proteins) mediated autocrine negative feedback loop, that acts via gp130 (show LRPPRC Proteins) to block adipogenesis through the essential actions of the STAT1 (show STAT1 Proteins) transcription factor.

  9. Osteocytic gp130 (show LRPPRC Proteins) is required to maintain PTH1R (show PTH1R Proteins) expression in the osteoblast lineage, and for the stimulation of osteoblast differentiation that occurs in response to PTH (show PTH Proteins).

  10. study concludes that in a setting of islet inflammation and pathophysiology modeling type 2 diabetes, activation of alpha-cell gp130 (show LRPPRC Proteins) receptor signaling has deleterious effects on alpha-cell function, promoting hyperglycemia.

Human Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) interaction partners

  1. High serum GP130 levels were associated with Chronic Spontaneous Urticaria.

  2. PECs exhibited higher proliferation in response to IL-6 (show IL6 Proteins)/sIL (show PMEL Proteins)-6R co-treatment compared with TECs in HCC (show FAM126A Proteins) via the up-regulation of gp130 /JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins).

  3. Mutations leading to constitutive active gp130/JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) pathway.

  4. In the present study, we analyze the role of a unique cysteine residue (Cys (show DNAJC5 Proteins)-628) within this C-terminus, which is contained neither in the membrane-bound gp130 nor in the two other sgp130 forms.

  5. pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements

  6. Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 (show IL6 Proteins) receptor pathway.

  7. Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6 (show IL6 Proteins)/gp130/STAT3 (show STAT3 Proteins) Pathway.

  8. Increased soluble gp130 in older patients may inhibit IL-6 (show IL6 Proteins) trans-signaling, impair barrier function, and decrease S100A8 (show S100A8 Proteins)/ S100A9 (show S100A9 Proteins) production in elderly chronic rhinosinusitis patients with asthma and nasal polyps.

  9. Data (including data from molecular dynamics simulation studies) suggest that conformation of GP130 (domains 2 and 3) changes and fluctuates only modestly (inter-domain angles vary only 125-140 degrees).

  10. GP130 signaling collaborated with MYC (show MYC Proteins) to induce MM and was responsible and sufficient for directing the plasma cell phenotype.

IL6ST Protein Profile

Protein Summary

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.

Alternative names and synonyms associated with IL6ST

  • interleukin 6 signal transducer (Il6st)
  • interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST)
  • 5133400A03Rik protein
  • AA389424 protein
  • Ac1055 protein
  • BB405851 protein
  • CD130 protein
  • CDW130 protein
  • D13Ertd699e protein
  • GP130 protein
  • IL-6RB protein

Protein level used designations for IL6ST

IL-6 receptor subunit beta , IL-6R subunit beta , IL-6R-beta , IL-6RB , interleukin-6 receptor subunit beta , interleukin-6 signal transducer , membrane glycoprotein 130 , oncostatin-M receptor subunit alpha , CD130 antigen , gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form , interleukin receptor beta chain , membrane glycoprotein gp130

16195 Mus musculus
25205 Rattus norvegicus
3572 Homo sapiens
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