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Browse our JAK1 Proteins (JAK1)

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Janus Kinase 1 Proteins (JAK1)
On are 12 Janus Kinase 1 (JAK1) Proteins from 6 different suppliers available. Additionally we are shipping JAK1 Antibodies (111) and JAK1 Kits (15) and many more products for this protein. A total of 144 JAK1 products are currently listed.
AA960307, C130039L05Rik, jak1, JAK1A, JAK1B, JNK, JNK1, JTK3, wu:fb93e10
list all proteins Gene Name GeneID UniProt
JAK1 3716 P23458
JAK1 16451  
Rat JAK1 JAK1 84598  

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JAK1 Proteins (JAK1) by Origin

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More Proteins for JAK1 Interaction Partners

Pig (Porcine) Janus Kinase 1 (JAK1) interaction partners

  1. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1 (show STAT1 Proteins)) signaling pathway.

  2. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.

  3. These data suggest that the p38 (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.

  4. based on the data, we can conclude that JNK (show MAPK8 Proteins) plays an active role in fragmentation of pig oocytes and that p38 MAPK (show MAPK14 Proteins) is not involved in this process

  5. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.

  6. PP2A (show PPP2R2B Proteins) and AIP1 (show PDCD6IP Proteins) cooperatively induce activation of ASK1 (show MAP3K5 Proteins)-JNK (show MAPK8 Proteins) signaling and vascular endothelial cell apoptosis.

  7. Phorbol 12-myristate 13-acetate activation of ERK (show MAPK1 Proteins) and JNK (show MAPK8 Proteins) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.

Rabbit Janus Kinase 1 (JAK1) interaction partners

  1. This is the first report of the genetic polymorphisms of the JAK1 and STAT3 (show STAT3 Proteins) genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Human Janus Kinase 1 (JAK1) interaction partners

  1. When association tests were applied to data from the Diabetes Heart Study, it found exome variants of POMGNT1 (show POMGNT1 Proteins) and JAK1 genes were associated with type 2 diabetes.

  2. Studies indicate that Janus kinase 1 (JAK1) inhibition leads to depression in inflammatory cytokine expression associated with MF-related constitutional symptoms.

  3. Mutations leading to constitutive active gp130 (show IL6ST Proteins)/JAK1/STAT3 (show STAT3 Proteins) pathway.

  4. Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 (show STAT3 Proteins) signaling

  5. Data show that IFN-lambda induced a faster but shorter expression of suppressor of cytokine signaling 1 (SOCS1 (show SOCS1 Proteins)) which inhibited Janus kinase/signal transducer and activator of transcription (show STAT1 Proteins) (Jak (show JAK3 Proteins)/STAT (show STAT1 Proteins)) pathway and phosphorylation.

  6. Shp-2 (show PTPN11 Proteins) contributes to the control of respiratory syncytial virus replication and progeny production in pulmonary alveolar epithelial cells by interfering with IFN-alpha (show IFNA Proteins)-induced Jak (show JAK3 Proteins)/Stat1 (show STAT1 Proteins) pathway activation

  7. Data show that JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling inhibition is potentiated by Bcl-xL (show BCL2L1 Proteins) (B-cell lymphoma-extra large) blockade in interleukin 2 (IL-2 (show IL2 Proteins)) dependent adult T-cell leukemia cells.

  8. Genetic variants of the genes JAK1 and the TNFAIP3 (show TNFAIP3 Proteins) were not associated with Behcet's disease in a Spanish population.

  9. Data indicate direct effects of sorafenib on the Janus kinase JAK1-transcription factors STAT3 (show STAT3 Proteins)/5 signaling pathway in immune cells.

  10. Expression analysis revealed upregulation of IL6 (show IL6 Proteins) and CD126 and GP130 (show IL6ST Proteins) in ALDH(hi) endometrial cancer ... targeted inhibition of the IL6 (show IL6 Proteins) receptor and its downstream effectors JAK1 and STAT3 (show STAT3 Proteins) reduced tumor cell growth.

Mouse (Murine) Janus Kinase 1 (JAK1) interaction partners

  1. Data indicate thar Janus kinase 1 (Jak1) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (show NDFIP1 Proteins)/Ndfip2 (show NDFIP2 Proteins).

  2. Experiments implicate JAK1/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice.

  3. JAK1/JAK2 (show JAK2 Proteins) inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.

  4. -1 promotes IFN-alpha (show IFNA Proteins)-induced autophagy via the JAK1-STAT1 (show STAT1 Proteins) signaling.

  5. Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production.

  6. JAK1 and JAK3 (show JAK3 Proteins) mutants cooperate in T-cell transformation

  7. Data suggest thatthat pharmacologic targeting of excessively activated wild-type Jak (show JAK3 Proteins) kinases Jak1/2 affords therapeutic suppression of inflammation-associated gastrointestinal cancers progression in vivo.

  8. Jak3 (show JAK3 Proteins) pseudokinase mutants require JAK1 for their transforming potential causing T-cell acute lymphoblastic leukemia in a mouse model.

  9. In cellular assays, SAR (show SRL Proteins)-20347 dose dependently (1 nM-10 muM) inhibited JAK1- and/or TYK2 (show TYK2 Proteins)-dependent signaling from the IL-12 (show IL12A Proteins)/IL-23 (show IL23A Proteins), IL-22 (show IL22 Proteins), and IFN-alpha (show IFNA Proteins) receptors.

  10. Disruption of PERK (show EIF2AK3 Proteins) abrogates endoplasmic reticulum stress-induced activation of STAT3 (show STAT3 Proteins) via JAK1.

Zebrafish Janus Kinase 1 (JAK1) interaction partners

JAK1 Protein Profile

Protein Summary

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Alternative names and synonyms associated with JAK1

  • Janus kinase 1 (JAK1)
  • mitogen-activated protein kinase 8 (MAPK8)
  • Tyrosine-protein kinase Jak1 (jak1)
  • Janus kinase 1 (jak1)
  • Janus kinase 1 (Jak1)
  • AA960307 protein
  • C130039L05Rik protein
  • jak1 protein
  • JAK1A protein
  • JAK1B protein
  • JNK protein
  • JNK1 protein
  • JTK3 protein
  • wu:fb93e10 protein

Protein level used designations for Janus Kinase 1 Proteins (JAK1)

Janus kinase 1 (a protein tyrosine kinase) , protein tyrosine kinase , tyrosine kinase JAK1 , tyrosine-protein kinase JAK1 , janus kinase 1 , Janus kinase 1 , Tyrosine-protein kinase Jak1 , tyrosine-protein kinase JAK1-like , JAK-1 , Janus protein tyrosine kinase 1 , etID309794.6 , fb93e10 , jak-1 , jak1 kinase

442952 Canis lupus familiaris
395681 Gallus gallus
396610 Sus scrofa
677689 Macaca mulatta
697808 Macaca mulatta
743373 Pan troglodytes
100031307 Monodelphis domestica
100286690 Salmo salar
100352594 Oryctolagus cuniculus
100385835 Callithrix jacchus
100433477 Pongo abelii
100473460 Ailuropoda melanoleuca
100559328 Anolis carolinensis
3716 Homo sapiens
16451 Mus musculus
84598 Rattus norvegicus
397202 Sus scrofa
537201 Bos taurus
30280 Danio rerio
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