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Browse our JAK1 Proteins (JAK1)

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Janus Kinase 1 Proteins (JAK1)
On are 13 Janus Kinase 1 (JAK1) Proteins from 7 different suppliers available. Additionally we are shipping JAK1 Antibodies (128) and JAK1 Kits (21) and many more products for this protein. A total of 169 JAK1 products are currently listed.
AA960307, C130039L05Rik, jak1, JAK1A, JAK1B, JNK, JNK1, JTK3, wu:fb93e10
list all proteins Gene Name GeneID UniProt
JAK1 3716 P23458
JAK1 16451  
Rat JAK1 JAK1 84598  

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JAK1 Proteins (JAK1) by Origin

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More Proteins for JAK1 Interaction Partners

Pig (Porcine) Janus Kinase 1 (JAK1) interaction partners

  1. Porcine reproductive and respiratory syndrome virus -activated TAK-1 (show NR2C2 Proteins) was essential for the activation of JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) pathways and IL-8 (show IL8 Proteins) expression.

  2. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Proteins)-STAT1 (show STAT1 Proteins)) signaling pathway.

  3. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.

  4. These data suggest that the p38 (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.

  5. based on the data, we can conclude that JNK (show MAPK8 Proteins) plays an active role in fragmentation of pig oocytes and that p38 MAPK (show MAPK14 Proteins) is not involved in this process

  6. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.

  7. PP2A (show PPP2R2B Proteins) and AIP1 (show PDCD6IP Proteins) cooperatively induce activation of ASK1 (show MAP3K5 Proteins)-JNK (show MAPK8 Proteins) signaling and vascular endothelial cell apoptosis.

  8. Phorbol 12-myristate 13-acetate activation of ERK (show MAPK1 Proteins) and JNK (show MAPK8 Proteins) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.

Rabbit Janus Kinase 1 (JAK1) interaction partners

  1. This is the first report of the genetic polymorphisms of the JAK1 and STAT3 (show STAT3 Proteins) genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Human Janus Kinase 1 (JAK1) interaction partners

  1. In this structure, the receptor peptide forms an 85-A-long extended chain, in which both the previously identified box1 and box2 regions bind simultaneously to the FERM and SH2-like domains of JAK1.

  2. Results reveal the structure of box1 from class II cytokine receptors IFNLR1 (show IL28RA Proteins) and IL10RA (show IL10RA Proteins) bound to the FERM-SH2 domain of human JAK1, identifying a consensus motif for JAK1 interaction.

  3. study demonstrated that miR (show MLXIP Proteins)-9 could inhibit activation of the NLRP3 (show NLRP3 Proteins) inflammasome and attenuate atherosclerosis-related inflammation, likely through the JAK1/STAT1 (show STAT1 Proteins) signaling pathway. Therefore, miR (show MLXIP Proteins)-9 may serve as a potential therapeutic target for atherosclerosis.

  4. miR (show MLXIP Proteins)-340 suppressed HCC (show FAM126A Proteins) cell proliferation and invasion by regulating the JAK1/STAT3 (show STAT3 Proteins) pathway

  5. this study identifies a psoriasis-protective JAK1 haplotype in the Korean population

  6. Data show that tight junction protein 1 (TJP1 (show TJP1 Proteins)) suppressed expression of the catalytically proteasome subunits LMP7 (show PSMB8 Proteins) and LMP2 (show PSMB9 Proteins), decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR (show EGFR Proteins)/JAK1/STAT3 (show STAT3 Proteins) signaling.

  7. EGFR (show EGFR Proteins) Del 19 may promote Fn14 (show TNFRSF12A Proteins) and JAK1/STAT1 (show STAT1 Proteins) expression in NSCLC.

  8. Piperlongumine reduced the phosphorylation of Janus kinase (JAK)1, JAK2 (show JAK2 Proteins) and signal transducer and activator of transcription (STAT (show STAT1 Proteins))3 (show STAT3 Proteins) in a concentrationdependent manner

  9. JAK1 rs310241 C-related genotype and allele are involved in AR susceptibility, making them potentially useful genetic biomarkers for allergic rhinitis susceptibility in the Chinese Han population.

  10. Data show that astaxanthin functions as a potent inhibitor of A549 lung cancer cell growth by targeting Janus kinase 1 a(JAK1)/STAT3 (show STAT3 Proteins) transcription factor (STAT3 (show STAT3 Proteins)) signaling pathway.

Mouse (Murine) Janus Kinase 1 (JAK1) interaction partners

  1. Data show that CUZD1 (show CUZD1 Proteins) interacts with a complex containing JAK1/JAK2 (show JAK2 Proteins) and STAT5 (show STAT5A Proteins), downstream transducers of prolactin (show PRL Proteins) signaling in the mammary gland.

  2. JAK1 conditional knockout mice will be an invaluable tool to study cytokine signaling during normal development and disease progression in adult animals.

  3. JAK1, JAK2 (show JAK2 Proteins), and JAK3 (show JAK3 Proteins) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.

  4. JAK (show JAK3 Proteins) mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.

  5. Data indicate thar Janus kinase 1 (Jak1) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (show NDFIP1 Proteins)/Ndfip2 (show NDFIP2 Proteins).

  6. Experiments implicate JAK1/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice.

  7. JAK1/JAK2 (show JAK2 Proteins) inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.

  8. -1 promotes IFN-alpha (show IFNA Proteins)-induced autophagy via the JAK1-STAT1 (show STAT1 Proteins) signaling.

  9. Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production.

  10. JAK1 and JAK3 (show JAK3 Proteins) mutants cooperate in T-cell transformation

Zebrafish Janus Kinase 1 (JAK1) interaction partners

  1. JAK1 activating mutants are insufficient to drive hepatocellular carcinoma development in vivo.

JAK1 Protein Profile

Protein Summary

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Alternative names and synonyms associated with JAK1

  • Janus kinase 1 (JAK1)
  • mitogen-activated protein kinase 8 (MAPK8)
  • Tyrosine-protein kinase Jak1 (jak1)
  • Janus kinase 1 (jak1)
  • Janus kinase 1 (Jak1)
  • AA960307 protein
  • C130039L05Rik protein
  • jak1 protein
  • JAK1A protein
  • JAK1B protein
  • JNK protein
  • JNK1 protein
  • JTK3 protein
  • wu:fb93e10 protein

Protein level used designations for Janus Kinase 1 Proteins (JAK1)

Janus kinase 1 (a protein tyrosine kinase) , protein tyrosine kinase , tyrosine kinase JAK1 , tyrosine-protein kinase JAK1 , janus kinase 1 , Janus kinase 1 , Tyrosine-protein kinase Jak1 , tyrosine-protein kinase JAK1-like , JAK-1 , Janus protein tyrosine kinase 1 , etID309794.6 , fb93e10 , jak-1 , jak1 kinase

442952 Canis lupus familiaris
395681 Gallus gallus
396610 Sus scrofa
677689 Macaca mulatta
697808 Macaca mulatta
743373 Pan troglodytes
100031307 Monodelphis domestica
100286690 Salmo salar
100352594 Oryctolagus cuniculus
100385835 Callithrix jacchus
100433477 Pongo abelii
100473460 Ailuropoda melanoleuca
100559328 Anolis carolinensis
3716 Homo sapiens
16451 Mus musculus
84598 Rattus norvegicus
397202 Sus scrofa
537201 Bos taurus
30280 Danio rerio
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