Browse our JAK3 Proteins (JAK3)

Full name:
Tyrosine-Protein Kinase JAK3 Proteins (JAK3)
On www.antibodies-online.com are 21 Tyrosine-Protein Kinase JAK3 (JAK3) Proteins from 9 different suppliers available. Additionally we are shipping JAK3 Antibodies (105) and JAK3 Kits (28) and many more products for this protein. A total of 162 JAK3 products are currently listed.
Synonyms:
fae, JAK, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, RATJAK3, wil
list all proteins Gene Name GeneID UniProt
JAK3 3718 P52333
JAK3 16453 Q62137
Rat JAK3 JAK3 25326  

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JAK3 Proteins (JAK3) by Origin

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More Proteins for JAK3 Interaction Partners

Human Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. frequency of JAK3 mutations in the JH2 domain was relatively low in extranodal natural killer/T-cell lymphoma, nasal type (NTCL) in contrast to a previous report; study identified novel JAK3H583Y- and JAK3G589D-activating mutations that were oncogenic and sensitive to a JAK3 inhibitor

  2. In natural killer/T-cell lymphoma (NKTL) as a disease model, phosphorylation of EZH2 (show EZH2 Proteins) by JAK3 promotes the dissociation of the PRC2 complex leading to decreased global histone H3 (show HIST3H3 Proteins) lysine 27 methylation levels.

  3. a causal relationship between MLH1 (show MLH1 Proteins)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  4. JAK3 mediates smooth muscle cell proliferation and survival during injury-induced vascular remodeling.

  5. Data indicate that phosphorylation of Janus kinase 3 (JAK3) and STAT3 (show STAT3 Proteins) transcription factor (STAT3 (show STAT3 Proteins)) was inhibited by latent membrane protein 1 (LMP1 (show PDLIM7 Proteins))-IgG.

  6. analysis of JAK3 kinetic mechanism and inhibition by tofacitinib

  7. patient had a homozygote of the JAK3 mutation, and her parents were heterozygous carriers.

  8. JAK3 up-regulates SGLT1 (show SLC5A1 Proteins) activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.

  9. JAK3 and MCL-1 (show MCL1 Proteins) were down-regulated in patient CD8 (show CD8A Proteins)(+) T cells versus their normal counterparts, likely due to defective suppressor activity of miR (show MLXIP Proteins)-29b and miR (show MLXIP Proteins)-198 in RCC (show XRCC1 Proteins) CD8 (show CD8A Proteins)(+) T cells.

  10. N225K and A550V PTPN6 (show PTPN6 Proteins) mutations cause loss-of-function leading to JAK3 mediated deregulation of STAT3 (show STAT3 Proteins) pathway and uncover a mechanism that tumor cells can use to control PTPN6 (show PTPN6 Proteins) substrate specificity.

Mouse (Murine) Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Small-scale in vivo screening identified several genes, including Cd109 (show CD109 Proteins), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (show STAT3 Proteins) as a critical, pharmacologically targetable effector of CD109 (show CD109 Proteins)-driven lung cancer metastasis

  2. a causal relationship between MLH1 (show MLH1 Proteins)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  3. JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and JAK3 are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.

  4. JAK mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.

  5. JAK3 up-regulates SGLT1 (show SLC5A1 Proteins) activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.

  6. This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 kinase activity in IL-2 (show IL2 Proteins)-driven T cell proliferation.

  7. Experiments implicate JAK1 (show JAK1 Proteins)/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice.

  8. Foxp3 (show FOXP3 Proteins) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT (show STAT1 Proteins) pathway

  9. JAK3 contributes to the regulation of membrane Kv1.5 (show KCNA5 Proteins) protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase (show ATP1A1 Proteins) activity.

  10. JAK3 deficiency is followed by down-regulation of cytosolic Ca(2 (show CA2 Proteins)+) release, receptor and store operated Ca(2 (show CA2 Proteins)+) entry and Na(+)/Ca(2 (show CA2 Proteins)+) exchanger activity in dendritic cells.

Pig (Porcine) Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.

JAK3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Alternative names and synonyms associated with JAK3

  • Janus kinase 3 (JAK3)
  • Janus kinase 3 (Jak3)
  • fae protein
  • JAK protein
  • JAK-3 protein
  • JAK3_HUMAN protein
  • JAKL protein
  • L-JAK protein
  • LJAK protein
  • RATJAK3 protein
  • wil protein

Protein level used designations for JAK3

Janus kinase 3 (a protein tyrosine kinase, leukocyte) , leukocyte Janus kinase , tyrosine-protein kinase JAK3 , JAK-3 , Janus kinase 3 protein-tyrosine kinase , Janus kinase 3, protein-tyrosine kinase , Janus tyrosine kinase

GENE ID SPECIES
100147451 Equus caballus
3718 Homo sapiens
16453 Mus musculus
25326 Rattus norvegicus
395845 Gallus gallus
610004 Canis lupus familiaris
100518649 Sus scrofa
538276 Bos taurus
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