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Browse our JAK3 Proteins (JAK3)

Full name:
Tyrosine-Protein Kinase JAK3 Proteins (JAK3)
On are 19 Tyrosine-Protein Kinase JAK3 (JAK3) Proteins from 9 different suppliers available. Additionally we are shipping JAK3 Antibodies (92) and JAK3 Kits (27) and many more products for this protein. A total of 145 JAK3 products are currently listed.
list all proteins Gene Name GeneID UniProt
JAK3 3718 P52333
JAK3 16453 Q62137
Rat JAK3 JAK3 25326  

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JAK3 Proteins (JAK3) by Origin

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Human Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Data indicate that phosphorylation of Janus kinase 3 (JAK3) and STAT3 (show STAT3 Proteins) transcription factor (STAT3 (show STAT3 Proteins)) was inhibited by latent membrane protein 1 (LMP1 (show PDLIM7 Proteins))-IgG.

  2. analysis of JAK3 kinetic mechanism and inhibition by tofacitinib

  3. patient had a homozygote of the JAK3 mutation, and her parents were heterozygous carriers.

  4. JAK3 up-regulates SGLT1 (show SLC5A1 Proteins) activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.

  5. JAK3 and MCL-1 (show MCL1 Proteins) were down-regulated in patient CD8 (show CD8A Proteins)(+) T cells versus their normal counterparts, likely due to defective suppressor activity of miR (show MLXIP Proteins)-29b and miR (show MLXIP Proteins)-198 in RCC (show XRCC1 Proteins) CD8 (show CD8A Proteins)(+) T cells.

  6. N225K and A550V PTPN6 (show PTPN6 Proteins) mutations cause loss-of-function leading to JAK3 mediated deregulation of STAT3 (show STAT3 Proteins) pathway and uncover a mechanism that tumor cells can use to control PTPN6 (show PTPN6 Proteins) substrate specificity.

  7. Study shows JAK3 mutations in 16% of patients with T-cell prolymphocytic leukemia which might be an important prognostic marker.

  8. This study showed that JAK3 is a powerful negative regulator of the creatine transporter SLC6A8 (show SLC6A8 Proteins).

  9. Letter/Case Report: ersistent rotavirus diarrhea post-transplant in a novel JAK3-SCID (show PRKDC Proteins) patient after vaccination.

  10. interleukin-4 (show IL4 Proteins) regulates hematopoietic lineage choice by activating the JAK3-STAT6 (show STAT6 Proteins) pathway, which causes dendritic-cell-specific DNA demethylation.

Mouse (Murine) Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and JAK3 are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.

  2. JAK mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.

  3. JAK3 up-regulates SGLT1 (show SLC5A1 Proteins) activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.

  4. This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 kinase activity in IL-2 (show IL2 Proteins)-driven T cell proliferation.

  5. Experiments implicate JAK1 (show JAK1 Proteins)/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice.

  6. Foxp3 (show FOXP3 Proteins) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT (show STAT1 Proteins) pathway

  7. JAK3 contributes to the regulation of membrane Kv1.5 (show KCNA5 Proteins) protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase (show ATP1A1 Proteins) activity.

  8. JAK3 deficiency is followed by down-regulation of cytosolic Ca(2 (show CA2 Proteins)+) release, receptor and store operated Ca(2 (show CA2 Proteins)+) entry and Na(+)/Ca(2 (show CA2 Proteins)+) exchanger activity in dendritic cells.

  9. Jak3 has a role in promoting mucosal tolerance through suppressed expression and limiting activation of TLRs thereby preventing intestinal and systemic chronic low-grade inflammation and associated obesity and MetS

  10. Our results demonstrate that JAK3/STAT6 (show STAT6 Proteins) has an important role in bone marrow-derived fibroblast activation, extracellular matrix production, and interstitial fibrosis development.

Pig (Porcine) Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.

JAK3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Alternative names and synonyms associated with JAK3

  • Janus kinase 3 (JAK3)
  • Janus kinase 3 (Jak3)
  • fae protein
  • JAK protein
  • JAK-3 protein
  • JAK3_HUMAN protein
  • JAKL protein
  • L-JAK protein
  • LJAK protein
  • RATJAK3 protein
  • wil protein

Protein level used designations for JAK3

Janus kinase 3 (a protein tyrosine kinase, leukocyte) , leukocyte Janus kinase , tyrosine-protein kinase JAK3 , JAK-3 , Janus kinase 3 protein-tyrosine kinase , Janus kinase 3, protein-tyrosine kinase , Janus tyrosine kinase

100147451 Equus caballus
3718 Homo sapiens
16453 Mus musculus
25326 Rattus norvegicus
395845 Gallus gallus
610004 Canis lupus familiaris
100518649 Sus scrofa
538276 Bos taurus
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