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Browse our MPL Proteins (MPL)

Full name:
Myeloproliferative Leukemia Virus Oncogene Proteins (MPL)
On www.antibodies-online.com are 15 Myeloproliferative Leukemia Virus Oncogene (MPL) Proteins from 6 different suppliers available. Additionally we are shipping MPL Antibodies (56) and MPL Kits (1) and many more products for this protein. A total of 75 MPL products are currently listed.
Synonyms:
C-MPL, c-mpl-I, c-mpl-II, CD110, hlb219, MPL, MPLV, THCYT2, TPO-R, TPOR
list all proteins Gene Name GeneID UniProt
MPL 4352 P40238
MPL 17480 Q08351
MPL 366455  

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MPL Proteins (MPL) by Origin

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Top referenced MPL Proteins

  1. Rat (Rattus) MPL Protein expressed in Baculovirus infected Insect Cells - ABIN2009520 : Bernard, Lecointe, Jonveaux, Souyri, Mauchauffé, Berger, Larsen, Mathieu-Mahul: Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. in Oncogene 1991 (PubMed)
    Show all 2 references for ABIN2009520

More Proteins for MPL Interaction Partners

Human Myeloproliferative Leukemia Virus Oncogene (MPL) interaction partners

  1. In essential thrombocythemia, MPL mutations might be associated with a higher risk of fibrotic transformation and the presence of JAK2 (show JAK2 Proteins)/MPL mutations with higher risk of thrombosis.

  2. PARP-1 (show PARP1 Proteins) has an important role in the progression of acute myeloid leukemia (show BCL11A Proteins) by suppressing the myeloproliferative leukemia virus oncogene

  3. mutant CALR (show CALR Proteins) promotes myeloproliferative neoplasm development by activating c-MPL and its downstream pathway.

  4. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin (show CALR Proteins) mutants.

  5. we describe a Mpl W515K somatic mutation in a paediatric case of ET who presented with Budd-Chiari syndrome. No paediatric patient harbouring a Mpl W515K mutation has been previously reported.

  6. His(499) regulates the activation of human TpoR and provides additional protection against activating mutations, such as oncogenic Asn mutations in the TM domain

  7. this study has shown that in a fraction of the so-called triple-negative ETs (show ETS1 Proteins) a significant proportion of patients have mutations in signaling molecules, more particularly in MPL.

  8. erythrocyte lineage enforces exclusivity through upregulation of EKLF (show KLF1 Proteins) and its lineage-specific cytokine receptor (show EBI3 Proteins) (EpoR (show EPOR Proteins)) while inhibiting both FLI-1 (show FLI1 Proteins) and the receptor TpoR (also known as MPL) for the opposing megakaryocyte lineage

  9. Compared to normal controls, the frequency of the JAK246/1 haplotype was significantly higher among patients with JAK2V617F, JAK2Ex12del, or MPL mutations, whereas no significant difference was found among CALR (show CALR Proteins) mutation-positive patients

  10. Flow cytometric detection of MPL (CD110) as a diagnostic tool for differentiation of congenital thrombocytopenias.

Mouse (Murine) Myeloproliferative Leukemia Virus Oncogene (MPL) interaction partners

  1. C-Mpl is expressed on osteoblasts and osteoclasts and is important in regulating skeletal homeostasis.

  2. CALR (show CALR Proteins) mutants are sufficient to induce thrombocytosis through MPL activation.

  3. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin (show CALR Proteins) mutants.

  4. The interaction between Mpl and Atp5d (show ATP5D Proteins) was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro.

  5. Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

  6. MERIT40 (show BABAM1 Proteins) deficiency triggers hypersensitivity to Tpo (show THPO Proteins) stimulation and the stem cell phenotypes are abrogated on a background null for the Tpo (show THPO Proteins) receptor Mpl.

  7. OTT1 regulates the alternative splicing of Mpl-TR, a truncated isoform of c-Mpl, which modulates Thrombopoietin (show THPO Proteins)-mediated signaling.

  8. Mpl expression, but not Tpo (show THPO Proteins), is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms

  9. Thrombopoietin (show THPO Proteins)/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Proteins) leukemia.

  10. These studies show the importance of the c-Mpl membrane-distal cytokine receptor (show LEPR Proteins) homology module to thrombopoietin (show THPO Proteins)-binding and suggest that mutations within this CRM that perturb TPO (show THPO Proteins) binding could give rise to Congenital Amegakaryocytic Thrombocytopenia.

MPL Protein Profile

Protein Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Alternative names and synonyms associated with MPL

  • myeloproliferative leukemia virus oncogene (MPL)
  • myeloproliferative leukemia virus oncogene (LOC100230798)
  • myeloproliferative leukemia virus oncogene (LOC100355135)
  • myeloproliferative leukemia virus oncogene (Mpl)
  • C-MPL protein
  • c-mpl-I protein
  • c-mpl-II protein
  • CD110 protein
  • hlb219 protein
  • MPL protein
  • MPLV protein
  • THCYT2 protein
  • TPO-R protein
  • TPOR protein

Protein level used designations for MPL

thrombopoietin receptor , myeloproliferative leukemia virus oncogene , thrombopoietin receptor-like , TPO-R , myeloproliferative leukemia protein , proto-oncogene c-Mpl

GENE ID SPECIES
414804 Gallus gallus
528492 Bos taurus
723813 Macaca mulatta
747522 Pan troglodytes
100008643 Oryctolagus cuniculus
100066544 Equus caballus
100230798 Taeniopygia guttata
100355135 Oryctolagus cuniculus
100448006 Pongo abelii
100626347 Sus scrofa
4352 Homo sapiens
17480 Mus musculus
366455 Rattus norvegicus
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