MPL Protein (AA 22-489) (His tag)
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- Target See all MPL Proteins
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-489
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Origin
- Cynomolgus
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MPL protein is labelled with His tag.
- Purpose
- Cynomolgus c-MPL/Thrombopoietin R Protein
- Sequence
- Gln22-Thr489
- Characteristics
- Recombinant Cynomolgus c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln22-Thr489.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Cynomolgus c-MPL, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-C-MPL Antibody, hFc Tag with the EC50 of 12.7ng/ml determined by ELISA. See testing image for detail.
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- Discover our top product MPL Protein
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Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) protein (His tag)
MPL Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-482) protein (His tag)MPL Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-635) protein (MBP tag,His tag)Crystallography grade MPL Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) protein (GST tag)MPL Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) protein (His tag)MPL Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Myeloproliferative Leukemia Virus Oncogene (MPL) protein (His tag)MPL Origin: Rat Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % Glycerol ( pH 7.5).
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- Alternative Name
- c-MPL (MPL Products)
- Synonyms
- C-MPL Protein, CD110 Protein, MPLV Protein, THCYT2 Protein, TPOR Protein, TPO-R Protein, c-mpl Protein, c-mpl-I Protein, c-mpl-II Protein, hlb219 Protein, MPL Protein, mpll Protein, tpor Protein, tpor.b Protein, MPL proto-oncogene, thrombopoietin receptor Protein, myeloproliferative leukemia virus oncogene Protein, MPL Protein, Mpl Protein, mpl Protein
- Background
- The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45 % of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
- Molecular Weight
- 53.48 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
- UniProt
- A0A2K5UGC7
- Pathways
- JAK-STAT Signaling
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