MPL Protein (His tag)

Catalog No. ABIN7321113

Product Details

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Protein Type: Recombinant

Origin: Rat

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This MPL protein is labelled with His tag.

Purpose: Recombinant Rat c-MPL/CD110/TPOR Protein (His Tag)

Sequence: Met1-Ala500

Characteristics: A DNA sequence encoding the mature form of rat MPL (Met1-Ala500) was expressed with a polyhistide tag at the C-terminus.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Alternative Name: c-MPL/CD110/TPOR (MPL Products)

Synonyms: C-MPL Protein, CD110 Protein, MPLV Protein, THCYT2 Protein, TPOR Protein, TPO-R Protein, c-mpl Protein, c-mpl-I Protein, c-mpl-II Protein, hlb219 Protein, MPL Protein, mpll Protein, tpor Protein, tpor.b Protein, MPL proto-oncogene, thrombopoietin receptor Protein, myeloproliferative leukemia virus oncogene Protein, MPL Protein, Mpl Protein, mpl Protein

Background:

Background: CD110, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for c-mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopeniawhich is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.

Synonym: MPL

Molecular Weight: 55.1 kDa

Pathways: JAK-STAT Signaling