Browse our anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies

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anti-Kelch-Like ECH-Associated Protein 1 Antibodies (KEAP1)
On are 163 Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies from 23 different suppliers available. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Kits (19) and Kelch-Like ECH-Associated Protein 1 Proteins (11) and many more products for this protein. A total of 209 Kelch-Like ECH-Associated Protein 1 products are currently listed.
fb36f11, Inrf2, keap1, KLHL19, mKIAA0132, wu:fb36f11
list all antibodies Gene Name GeneID UniProt
KEAP1 9817 Q14145
KEAP1 50868 Q9Z2X8
KEAP1 117519  

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All available anti-Kelch-Like ECH-Associated Protein 1 Antibodies

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Top referenced anti-Kelch-Like ECH-Associated Protein 1 Antibodies

  1. Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085 : Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015 (PubMed)
    Show all 3 references for 702085

  2. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141 : Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011 (PubMed)
    Show all 2 references for 1098141

  3. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954 : Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014 (PubMed)
    Show all 2 references for 2453954

  4. Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775979 : Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006 (PubMed)
    Show all 2 references for 2775979

  5. Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137 : Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010 (PubMed)
    Show all 2 references for 1098137

More Antibodies against Kelch-Like ECH-Associated Protein 1 Interaction Partners

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. NRF2 (show GABPA Antibodies) is regulated at protein level by proteasomal degradation via KEAP1. Data suggest that antioxidant-induced up-regulation of NRF2 (show GABPA Antibodies) expression (a) overcomes KEAP1 regulation, (b) activates NRF2 (show GABPA Antibodies) translocation to nucleus, and (c) activates antioxidant response element. (NRF2 (show GABPA Antibodies) = nuclear factor [erythroid-derived 2]-like 2 protein; KEAP1 = Kelch-like ECH-associated protein 1)

  2. Results indicate that microRNA miR (show MLXIP Antibodies)-141 targets kelch like ECH associated protein 1 (Keap1) to activate NF-E2-related factor 2 (Nrf2 (show NFE2L2 Antibodies)) signaling, which protects retinal pigment epithelium cells (RPEs) and retinal ganglion cells (RGCs) from UV radiation.

  3. The authors show that O-GlcNAcylation of KEAP1 by OGT (show OGT Antibodies) at serine 104 is required for the efficient ubiquitination and degradation of NRF2 (show GABPA Antibodies).

  4. Data indicate the role of kelch like ECH associated protein 1 (Keap1)/nuclear factor E2-related factor 2 (Nrf2 (show GABPA Antibodies)) axis deregulation with potential new function as independent epigenetic prognostic marker in renal cell carcinoma (show MOK Antibodies).

  5. clinical cholangiocarcinoma samples displayed FoxO3 (show FOXO3 Antibodies)-Keap1 down-regulation and Nrf2 (show GABPA Antibodies) hyperactivation

  6. the dual role of nuclear factor-erythroid 2 signaling in induction of colorectal cancer cell survival and death as well as the possibility of targeting nuclear factor-erythroid 2-kelch-like ECH-associated protein 1 axis as an advanced strategy in prevention and effective treatment of colorectal cancer patients have been discussed.

  7. p97 (show EIF4G2 Antibodies) negatively regulates NRF2 (show GABPA Antibodies) through the canonical pathway by extracting ubiquitylated NRF2 (show GABPA Antibodies) from the KEAP1-CUL3 (show CUL3 Antibodies) E3 complex.

  8. Using a combination of biochemical and mass spectrometry studies, the authors show that VP24 is a dimer in solution that directly binds to the Kelch domain of Kelch-like ECH-associated protein 1 (Keap1) to regulate nuclear factor (erythroid-derived 2)-like 2 (Nrf2 (show NFE2L2 Antibodies)).

  9. These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.

  10. ur results identify WDR23 (show DCAF11 Antibodies) as an alternative regulator of NRF2 (show GABPA Antibodies) proteostasis and uncover a cellular pathway that regulates NRF2 (show GABPA Antibodies) activity and capacity for cytoprotection independently of KEAP1.

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. Results show that Keap1 deficiency in long-term hematopoietic stem cells increases the number of multipotent progenitor cells in steady-state hematopoiesis, and impairs their hematopoietic regeneration capacity .

  2. During cellular stress or electrolytic imbalance, cysteine residue modification in Keap1 induces Nrf2 (show NFE2L2 Antibodies) release from the Nrf2 (show NFE2L2 Antibodies)-Keap1 complex, which stabilizes Nrf2 (show NFE2L2 Antibodies) and causes its nuclear translocation.

  3. Results showed that in the basal state, the amount of Keap1 and Cul3 (show CUL3 Antibodies) proteins were maintained at higher levels than that of Nrf2 (show NFE2L2 Antibodies), and remained the same even under oxidative and electrophilic stimuli.

  4. This study found that under oxidative stress induced (show SQSTM1 Antibodies) by experimental periodontitis, the Nrf2 (show NFE2L2 Antibodies)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.

  5. Caffeic acid induces Nrf2 (show NFE2L2 Antibodies) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Antibodies) with Keap1.

  6. Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Antibodies) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.

  7. findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Antibodies) independently of its role in oxidant stress responses.

  8. chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Antibodies) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Antibodies) production to normoglycemic levels.

  9. conclusion, increased Keap1/Nrf2 (show NFE2L2 Antibodies) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.

  10. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function

  2. study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds

Kelch-Like ECH-Associated Protein 1 (KEAP1) Antigen Profile

Antigen Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Alternative names and synonyms associated with Kelch-Like ECH-Associated Protein 1 (KEAP1)

  • kelch-like ECH-associated protein 1 (KEAP1) antibody
  • kelch-like ECH-associated protein 1 (keap1) antibody
  • kelch-like ECH-associated protein 1 (LOC100346935) antibody
  • kelch-like ECH-associated protein 1 (Keap1) antibody
  • Kelch-like ECH-associated protein 1 (Keap1) antibody
  • kelch-like ECH-associated protein 1a (keap1a) antibody
  • fb36f11 antibody
  • Inrf2 antibody
  • keap1 antibody
  • KLHL19 antibody
  • mKIAA0132 antibody
  • wu:fb36f11 antibody

Protein level used designations for KEAP1

kelch-like ECH-associated protein 1 , cytosolic inhibitor of Nrf2 , kelch-like family member 19 , kelch-like protein 19 , NRF2 cytosolic inhibitor , ring canal protein

455706 Pan troglodytes
493386 Xenopus (Silurana) tropicalis
100346935 Oryctolagus cuniculus
9817 Homo sapiens
476713 Canis lupus familiaris
100136900 Sus scrofa
532791 Bos taurus
50868 Mus musculus
117519 Rattus norvegicus
496326 Xenopus laevis
100173389 Pongo abelii
321837 Danio rerio
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