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Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085
Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141
Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011
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Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137
Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010
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Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954
Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014
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Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775979
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
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Human Polyclonal KEAP1 Primary Antibody for ELISA, IHC - ABIN4328595
Dinkova-Kostova, Talalay, Sharkey, Zhang, Holtzclaw, Wang, David, Schiavoni, Finlayson, Mierke, Honda: An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. in The Journal of biological chemistry 2010
Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN4328597
Licht-Mayer, Wimmer, Traffehn, Metz, Brück, Bauer, Bradl, Lassmann: Cell type-specific Nrf2 expression in multiple sclerosis lesions. in Acta neuropathologica 2015
Data suggest that Keap1, rather than Nrf2 (show GABPA Antibodies), is critical for the recruitment of iASPP (show PPP1R13L Antibodies) into the Keap1-Nrf2 (show GABPA Antibodies) complex
The modification of NRF2 (show GABPA Antibodies) or KEAP1 expression in non-small cell lung cancer cell lines disrupted downstream gene expression and cell sensitivity to platinum-based drugs.
These data demonstrate that the beneficial properties of SFN (show SFN Antibodies) extend beyond activation of the KEAP1-Nrf2 (show GABPA Antibodies)-ARE system and warrant further interrogation given the current use of this agent in multiple clinical trials
Result showed that there was a significant association between Keap1 and phosphorylated (p) Nrf2 (show GABPA Antibodies) expression in hepatocellular carcinoma. Higher pNrf2 expression was more likely observed in those specimens with reduced Keap1 expression.
Results provide evidence for a critical role of mutations in TP53 (show TP53 Antibodies) and KEAP1 during lung squamous cell carcinoma (LSCC oncogenesis, because deletion of either gene leads to increased self-renewal of airway basal stem cells. Also, KEAP1/NRF2 (show GABPA Antibodies) mutations increase radioresistance and predict local tumor recurrence in radiotherapy treated LSCC patients.
Study showed that Sequestosome 1 (show SQSTM1 Antibodies)-mediated sequestration of Keap1 is associated with chronic activation of the Nrf2 (show GABPA Antibodies) stress response pathway in the autophagic vacuolar myopathie muscle; demonstrated that Nrf2 (show GABPA Antibodies) signaling is upregulated in autophagic muscle disorders and raise the possibility that autophagy disruption in skeletal muscle leads to dysregulation of cellular redox homeostasis.
Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3 (show CUL3 Antibodies)-based E3 ubiquitin ligase (show MUL1 Antibodies). Keap1 regulates the activity of Nrf2 (show GABPA Antibodies) and acts as a sensor for oxidative and electrophilic stresses.
NRF2 (show GABPA Antibodies) is regulated at protein level by proteasomal degradation via KEAP1. Data suggest that antioxidant-induced up-regulation of NRF2 (show GABPA Antibodies) expression (a) overcomes KEAP1 regulation, (b) activates NRF2 (show GABPA Antibodies) translocation to nucleus, and (c) activates antioxidant response element. (NRF2 (show GABPA Antibodies) = nuclear factor [erythroid-derived 2]-like 2 protein; KEAP1 = Kelch-like ECH-associated protein 1)
Results indicate that microRNA miR (show MLXIP Antibodies)-141 targets kelch like ECH associated protein 1 (Keap1) to activate NF-E2-related factor 2 (Nrf2 (show NFE2L2 Antibodies)) signaling, which protects retinal pigment epithelium cells (RPEs) and retinal ganglion cells (RGCs) from UV radiation.
The authors show that O-GlcNAcylation of KEAP1 by OGT (show OGT Antibodies) at serine 104 is required for the efficient ubiquitination and degradation of NRF2 (show GABPA Antibodies).
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
Keap1 deletion in renal tubular cells results in an abnormal kidney development consistent with hydronephrosis.
serine 351 phosphorylation of p62 (show GTF2H1 Antibodies) did not enhance its binding to Keap1 or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 Antibodies)) transcription factor in this neuronal context. Nrf2 (show NFE2L2 Antibodies) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (show NFE2L2 Antibodies) gene
These results suggest that the Keap1/Nrf2 (show NFE2L2 Antibodies) axis plays a critical role in NFATc1 (show NFATC1 Antibodies) expression and osteoclastogenic progression.
Results show that Keap1 deficiency in long-term hematopoietic stem cells increases the number of multipotent progenitor cells in steady-state hematopoiesis, and impairs their hematopoietic regeneration capacity .
During cellular stress or electrolytic imbalance, cysteine residue modification in Keap1 induces Nrf2 (show NFE2L2 Antibodies) release from the Nrf2 (show NFE2L2 Antibodies)-Keap1 complex, which stabilizes Nrf2 (show NFE2L2 Antibodies) and causes its nuclear translocation.
Results showed that in the basal state, the amount of Keap1 and Cul3 (show CUL3 Antibodies) proteins were maintained at higher levels than that of Nrf2 (show NFE2L2 Antibodies), and remained the same even under oxidative and electrophilic stimuli.
This study found that under oxidative stress induced (show SQSTM1 Antibodies) by experimental periodontitis, the Nrf2 (show NFE2L2 Antibodies)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.
Caffeic acid induces Nrf2 (show NFE2L2 Antibodies) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Antibodies) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Antibodies) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Antibodies) independently of its role in oxidant stress responses.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein