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Browse our anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies

Full name:
anti-Kelch-Like ECH-Associated Protein 1 Antibodies (KEAP1)
On www.antibodies-online.com are 142 Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies from 22 different suppliers available. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Kits (14) and Kelch-Like ECH-Associated Protein 1 Proteins (11) and many more products for this protein. A total of 183 Kelch-Like ECH-Associated Protein 1 products are currently listed.
Synonyms:
fb36f11, Inrf2, keap1, KLHL19, mKIAA0132, wu:fb36f11
list all antibodies Gene Name GeneID UniProt
KEAP1 9817 Q14145
KEAP1 50868 Q9Z2X8
KEAP1 117519  

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All available anti-Kelch-Like ECH-Associated Protein 1 Antibodies

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Top referenced anti-Kelch-Like ECH-Associated Protein 1 Antibodies

  1. Human Polyclonal KEAP1 Primary Antibody for EIA, IF - ABIN1449975 : Zhang, Lo, Cross, Templeton, Hannink: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for ABIN1449975

  2. Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085 : Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015 (PubMed)
    Show all 3 references for ABIN702085

  3. Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137 : Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010 (PubMed)
    Show all 2 references for ABIN1098137

  4. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141 : Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011 (PubMed)
    Show all 2 references for ABIN1098141

  5. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954 : Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014 (PubMed)
    Show all 2 references for ABIN2453954

  6. Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775978 : Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006 (PubMed)

More Antibodies against Kelch-Like ECH-Associated Protein 1 Interaction Partners

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.

  2. ur results identify WDR23 (show DCAF11 Antibodies) as an alternative regulator of NRF2 (show GABPA Antibodies) proteostasis and uncover a cellular pathway that regulates NRF2 (show GABPA Antibodies) activity and capacity for cytoprotection independently of KEAP1.

  3. Keap1 orchestrates the antioxidant response; the system can be targeted for therapy [review]

  4. Keap1 is the main negative regulator of Nrf2 (show GABPA Antibodies) [review]

  5. Results show that GSTP (show GSTP1 Antibodies) potentiates S-glutathionylation of Keap1, which leads to Nrf2 (show GABPA Antibodies) activation and subsequently increases expression of GSTP (show GSTP1 Antibodies). This positive feedback regulatory loop represents a novel mechanism by which GSTP (show GSTP1 Antibodies) elicits antioxidant protection in the brain.

  6. EMT (show ITK Antibodies) signalling and the KEAP1/NFE2L2 (show NFE2L2 Antibodies)-axis are likely to be involved in metastatic spread of malignant melanoma and also appear to have potential interactions.

  7. the expression of NRF2 (show GABPA Antibodies), KEAP1, NQO-1 (show NQO1 Antibodies) and HO-1 (show HMOX1 Antibodies) are increased significantly in advanced laryngeal squamous cell carcinoma, compared with the adjacent normal mucosa. Remarkable relevance exists between high expression of KEAP1, NQO-1 (show NQO1 Antibodies), HO-1 (show HMOX1 Antibodies) and nuclear NRF2 (show GABPA Antibodies). their expression levels were independent of age, tumor stage (clinical stage III and IV), tumor size and lymph node metastasis.

  8. miR (show MLXIP Antibodies)-200a was found to interact with the 3'-untranslated region of Keap1, the native regulator of Nrf2 (show GABPA Antibodies).

  9. We present the case that chemoprevention through the Keap1/Nrf2 (show GABPA Antibodies) system may be context dependent and that the Nrf2 (show GABPA Antibodies) "dose-response curve" for electrophilic and redox balance may not be monotonic.

  10. Immunohistochemical assays were used to measure the expression of Keap1 protein in breast cancer tissue and adjacent normal tissue, and its clinical significance was explored. We observed that 24.6% breast cancer tissue samples were positive for Keap1, a significantly lower proportion than that seen with adjacent normal tissue specimens

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. This study found that under oxidative stress induced (show SQSTM1 Antibodies) by experimental periodontitis, the Nrf2 (show NFE2L2 Antibodies)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.

  2. Caffeic acid induces Nrf2 (show NFE2L2 Antibodies) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Antibodies) with Keap1.

  3. Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Antibodies) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.

  4. findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Antibodies) independently of its role in oxidant stress responses.

  5. chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Antibodies) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Antibodies) production to normoglycemic levels.

  6. conclusion, increased Keap1/Nrf2 (show NFE2L2 Antibodies) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.

  7. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.

  8. iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 Antibodies) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 Antibodies).

  9. These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.

  10. Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function

  2. study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds

Kelch-Like ECH-Associated Protein 1 (KEAP1) Antigen Profile

Antigen Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Alternative names and synonyms associated with Kelch-Like ECH-Associated Protein 1 (KEAP1)

  • kelch-like ECH-associated protein 1 (KEAP1) antibody
  • kelch-like ECH-associated protein 1 (keap1) antibody
  • kelch-like ECH-associated protein 1 (LOC100346935) antibody
  • kelch-like ECH-associated protein 1 (Keap1) antibody
  • Kelch-like ECH-associated protein 1 (Keap1) antibody
  • kelch-like ECH-associated protein 1a (keap1a) antibody
  • fb36f11 antibody
  • Inrf2 antibody
  • keap1 antibody
  • KLHL19 antibody
  • mKIAA0132 antibody
  • wu:fb36f11 antibody

Protein level used designations for KEAP1

kelch-like ECH-associated protein 1 , cytosolic inhibitor of Nrf2 , kelch-like family member 19 , kelch-like protein 19 , NRF2 cytosolic inhibitor , ring canal protein

GENE ID SPECIES
455706 Pan troglodytes
493386 Xenopus (Silurana) tropicalis
100346935 Oryctolagus cuniculus
9817 Homo sapiens
476713 Canis lupus familiaris
100136900 Sus scrofa
532791 Bos taurus
50868 Mus musculus
117519 Rattus norvegicus
496326 Xenopus laevis
100173389 Pongo abelii
321837 Danio rerio
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