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Human KEAP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004957
Strachan, Morgan, Otis, Caltagarone, Gittis, Bowser, Jordan-Sciutto: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein. in Biochemistry 2004
Show all 4 references for ABIN2004957
Human KEAP1 Protein expressed in HEK-293 Cells - ABIN2724103
Lieder, Reisen, Geppert, Sollberger, Beer, auf dem Keller, Schäfer, Detmar, Schneider, Werner: Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening. in The Journal of biological chemistry 2012
Show all 2 references for ABIN2724103
Human KEAP1 Protein expressed in Wheat germ - ABIN1308530
Yuan, Ji, Luo, Lu, Ma, Ma, Chen: Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide. in Fitoterapia 2012
These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.
ur results identify WDR23 (show DCAF11 Proteins) as an alternative regulator of NRF2 (show GABPA Proteins) proteostasis and uncover a cellular pathway that regulates NRF2 (show GABPA Proteins) activity and capacity for cytoprotection independently of KEAP1.
Keap1 orchestrates the antioxidant response; the system can be targeted for therapy [review]
Keap1 is the main negative regulator of Nrf2 (show GABPA Proteins) [review]
Results show that GSTP (show GSTP1 Proteins) potentiates S-glutathionylation of Keap1, which leads to Nrf2 (show GABPA Proteins) activation and subsequently increases expression of GSTP (show GSTP1 Proteins). This positive feedback regulatory loop represents a novel mechanism by which GSTP (show GSTP1 Proteins) elicits antioxidant protection in the brain.
EMT (show ITK Proteins) signalling and the KEAP1/NFE2L2 (show NFE2L2 Proteins)-axis are likely to be involved in metastatic spread of malignant melanoma and also appear to have potential interactions.
the expression of NRF2 (show GABPA Proteins), KEAP1, NQO-1 (show NQO1 Proteins) and HO-1 (show HMOX1 Proteins) are increased significantly in advanced laryngeal squamous cell carcinoma, compared with the adjacent normal mucosa. Remarkable relevance exists between high expression of KEAP1, NQO-1 (show NQO1 Proteins), HO-1 (show HMOX1 Proteins) and nuclear NRF2 (show GABPA Proteins). their expression levels were independent of age, tumor stage (clinical stage III and IV), tumor size and lymph node metastasis.
miR (show MLXIP Proteins)-200a was found to interact with the 3'-untranslated region of Keap1, the native regulator of Nrf2 (show GABPA Proteins).
We present the case that chemoprevention through the Keap1/Nrf2 (show GABPA Proteins) system may be context dependent and that the Nrf2 (show GABPA Proteins) "dose-response curve" for electrophilic and redox balance may not be monotonic.
Immunohistochemical assays were used to measure the expression of Keap1 protein in breast cancer tissue and adjacent normal tissue, and its clinical significance was explored. We observed that 24.6% breast cancer tissue samples were positive for Keap1, a significantly lower proportion than that seen with adjacent normal tissue specimens
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Proteins) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
This study found that under oxidative stress induced (show SQSTM1 Proteins) by experimental periodontitis, the Nrf2 (show NFE2L2 Proteins)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.
Caffeic acid induces Nrf2 (show NFE2L2 Proteins) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Proteins) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Proteins) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Proteins) independently of its role in oxidant stress responses.
chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Proteins) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Proteins) production to normoglycemic levels.
conclusion, increased Keap1/Nrf2 (show NFE2L2 Proteins) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.
Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.
iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 Proteins) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 Proteins).
These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.
Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Proteins), indicating that the presence of either Cys (show DNAJC5 Proteins)-273 or Cys (show DNAJC5 Proteins)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 Proteins) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Proteins)-151 and Cys (show DNAJC5 Proteins)-273, for a variety of Nrf2 (show NFE2L2 Proteins)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein