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Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Cdc42 GTPase (show RACGAP1 ELISA Kits) and Rac1 GTPase (show RACGAP1 ELISA Kits) act downstream of p120 catenin (show CTNND1 ELISA Kits) and require GTP (show AK3 ELISA Kits) exchange during gastrulation of zebrafish mesoderm.
These results suggest that Ptenb by antagonizing PI3 kinase and its downstream Akt1 and Cdc42 to regulate actin polymerization that is critical for proper cell motility and migration control during gastrulation in zebrafish.
This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.
The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.
these data indicate that the ITSN2 exchange factor regulates the activity of Cdc42 during embryo development affecting actin cytoskeleton in Xenopus embryos.
These results demonstrate that to participate in the control of the actin cytoskeleton, RLIP needs its complete N-terminal region coding for the mu2BD and the GAP domain.
Data show that in Xenopus laevis oocytes, polar body emission requires a RhoA (show RHOA ELISA Kits) contractile ring and Cdc42-mediated membrane protrusion.
In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure.
Cdc42 controls protrusion formation in a cell non-autonomous manner.
Cdc42 regulates binding of Crumbs protein to the Par-6 (show PARD6A ELISA Kits) CRIB (show SCRIB ELISA Kits)-PDZ (show INADL ELISA Kits) module.
We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development
A proof-of-principle experiment in which the Cdc42 GTPase (show RACGAP1 ELISA Kits) associates with its alleged partner WASp (show WASL ELISA Kits) within neurons during the time and space that coincide with the newly developing CNS.
The distinct buttoning mechanism we propose for dorsal vessel closure is elaborated through signaling pathways regulating Cdc42 activity in this cell type.
there is a mutual dependence between Par proteins and Cdc42 for their localization, regulation of the actin cytoskeleton and, consequently, for the establishment of oocyte polarity
Zir is necessary to activate the Rho-family GTPases Rac2 (show RAC2 ELISA Kits) and Cdc42 during the Drosophila cellular immune response.
Results identify the Cdc42/Par6 (show PARD6A ELISA Kits)/atypical protein kinase C (show PRKCZ ELISA Kits) (aPKC) Par (show AFG3L2 ELISA Kits) polarity complex as uniquely and specifically regulating apoptosis-induced compensatory proliferation in Drosophila epithelia.
Wsp activity in within the fly testis is mediated by the small GTPase (show RACGAP1 ELISA Kits) Cdc42.
Data demonstrate that Cdc42 and Merlin (show NF2 ELISA Kits) act together with Pak1 (show PAK1 ELISA Kits) to control salivary gland lumen size.
Hypoxic pulmonary arterial myocytes challenged with a thromboxane mimetic polymerize actin via the Cdc42 pathway, reflecting increased Cdc42 association with neuronal Wiskott Aldrich Syndrome protein.
Cdc42 is involved in the regulation of alppha-smooth muscle actin promoter activation through p21 (show CDKN1A ELISA Kits)-activated kinase, p38 (show MAPK14 ELISA Kits), myocardin (show MYOCD ELISA Kits)-related transcription factor and serum response factor. Cdc42 may be an important regulator of MRTF cellular localization
CDC42 loss suppresses acute myeloid leukemia (show BCL11A ELISA Kits) cell polarity and division asymmetry.
The structural basis for Cdc42-induced dimerization of IQGAP1 (show IQGAP1 ELISA Kits) and IQGAP2 (show IQGAP2 ELISA Kits) has been uncovered.
Polarity signaling via CDC42/atypical protein kinase C (show PRKCZ ELISA Kits) can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.
Circular RNA ccHIAT1 functions as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion via miR (show MLXIP ELISA Kits)-195-5p/29a-3p/29c-3p/CDC42 signaling pathway.
CDC42 plays an important role in promoting pancreatic cancer development and might serve as a prognostic indicator of pancreatic cancer.
These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.
rapamycin inhibits the RhoA (show RHOA ELISA Kits), Rac1, and Cdc42 activated by high glucose(HG). Thus, rapamycin shows an obvious protective effect on HG-induced Epithelial-mesenchymal transition, by inhibiting the activation of Rho GTPases (RhoA (show RHOA ELISA Kits), Rac1, and Cdc42).
Akt3 (show AKT3 ELISA Kits) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 ELISA Kits)/SGK1 (show SGK1 ELISA Kits)/Cdc42 pathway.
These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions.
Report shows Cdc42 as a downstream target of miR (show MLXIP ELISA Kits)-107.
CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
LRCH1 (show LRCH1 ELISA Kits) as a novel effector to restrain PKCalpha (show PKCa ELISA Kits)-DOCK8 (show DOCK8 ELISA Kits)-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).
analysis of phenotypes of Cdc42 and Myo10 (show MYO10 ELISA Kits) deletion that show multiple roles of filopodial dynamics
Finally, we demonstrate that Cdc42 is involved in neuroligin-dependent presynaptic differentiation of proprioceptive sensory neurons in vitro These data suggest that Cdc42 in presynaptic sensory neurons is essential for proper synapse formation in the development of monosynaptic sensory-motor circuits.
found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain
These results indicate that HuR (show ELAVL1 ELISA Kits) promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
Lrrk1 deficiency in osteoclasts resulted in reduced phosphorylation and activation of RAC1/Cdc42
Cdc42 is essential for cardiomyocyte proliferation, sarcomere organization and cell-cell adhesion during heart development.
shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex.
This study revealed a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell.
These data are consistent with the idea that migrating corneal epithelial cells use a cdc42/rho "switch" to sort vectoral cues, with cdc42 controlling electrotaxis and rho controlling contact guidance.
genetic interactions with CDC42-related genes MSB1, a putative scaffold protein, and RGD3, a putative Rho GTPase-activating protein (GAP) were identified
Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.
These results suggest the development of hyphal-specific characteristics is promoted by Cdc42-GTP (show AK3 ELISA Kits) in a process that also requires the intrinsic GTPase (show RACGAP1 ELISA Kits) activity of Cdc42.
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
Cdc42 protein homolog
, cell division control protein 42 homolog
, cell division cycle 42 (GTP binding protein, 25kDa)
, cell division cycle 42 homolog
, Cell division control protein 42 homolog
, cell division control protein 42-like protein
, G25K GTP-binding protein
, GTP binding protein, 25kDa
, GTP-binding protein, 25kD
, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
, dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
, growth-regulating protein
, small GTP binding protein CDC42
, CDC42 GTP-binding protein
, likely rho family Ras-like GTPase