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Browse our CDC42 Proteins (CDC42)

Full name:
Cell Division Cycle 42 (GTP Binding Protein, 25kDa) Proteins (CDC42)
On are 24 Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) Proteins from 8 different suppliers available. Additionally we are shipping CDC42 Antibodies (104) and CDC42 Kits (11) and many more products for this protein. A total of 156 CDC42 products are currently listed.
AI747189, AU018915, Cdc42, cdc42a, Cdc42Dm, CDC42Hs, CG12530, D-cdc42, Dcdc42, Dm Cdc42, Dmcdc42, Dmel\\CG12530, G25K, wu:fb07d08, wu:fi33d02, wu:fj62g06, Xcdc42, zgc:55427, zgc:63918, zgc:86687
list all proteins Gene Name GeneID UniProt
CDC42 998 P60953
CDC42 12540 P60766
CDC42 64465 Q8CFN2

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CDC42 Proteins (CDC42) by Origin

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Top referenced CDC42 Proteins

  1. Human CDC42 Protein expressed in Escherichia coli (E. coli) - ABIN666665 : Harris, Tepass: Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. in The Journal of cell biology 2008 (PubMed)
    Show all 2 references for ABIN666665

  2. Human CDC42 Protein expressed in Escherichia coli (E. coli) - ABIN2001997 : Yasuda, Narumiya: Analysis of a mitotic role of Cdc42. in Methods in enzymology 2006 (PubMed)

More Proteins for CDC42 Interaction Partners

Zebrafish Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.

  2. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.

  3. Cdc42 GTPase (show RACGAP1 Proteins) and Rac1 GTPase (show RACGAP1 Proteins) act downstream of p120 catenin (show CTNND1 Proteins) and require GTP (show AK3 Proteins) exchange during gastrulation of zebrafish mesoderm.

  4. These results suggest that Ptenb by antagonizing PI3 kinase and its downstream Akt1 and Cdc42 to regulate actin polymerization that is critical for proper cell motility and migration control during gastrulation in zebrafish.

Xenopus laevis Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.

  2. The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.

  3. these data indicate that the ITSN2 exchange factor regulates the activity of Cdc42 during embryo development affecting actin cytoskeleton in Xenopus embryos.

  4. These results demonstrate that to participate in the control of the actin cytoskeleton, RLIP needs its complete N-terminal region coding for the mu2BD and the GAP domain.

  5. Data show that in Xenopus laevis oocytes, polar body emission requires a RhoA (show RHOA Proteins) contractile ring and Cdc42-mediated membrane protrusion.

  6. In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure.

Fruit Fly (Drosophila melanogaster) Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. Cdc42 regulates binding of Crumbs protein to the Par-6 CRIB-PDZ module.

  2. We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development

  3. A proof-of-principle experiment in which the Cdc42 GTPase (show RACGAP1 Proteins) associates with its alleged partner WASp (show WASL Proteins) within neurons during the time and space that coincide with the newly developing CNS.

  4. The distinct buttoning mechanism we propose for dorsal vessel closure is elaborated through signaling pathways regulating Cdc42 activity in this cell type.

  5. there is a mutual dependence between Par proteins and Cdc42 for their localization, regulation of the actin cytoskeleton and, consequently, for the establishment of oocyte polarity

  6. Zir is necessary to activate the Rho-family GTPases Rac2 (show RAC2 Proteins) and Cdc42 during the Drosophila cellular immune response.

  7. Results identify the Cdc42/Par6 (show PARD6A Proteins)/atypical protein kinase C (show PRKCZ Proteins) (aPKC) Par (show AFG3L2 Proteins) polarity complex as uniquely and specifically regulating apoptosis-induced compensatory proliferation in Drosophila epithelia.

  8. Wsp activity in within the fly testis is mediated by the small GTPase (show RACGAP1 Proteins) Cdc42.

  9. Data demonstrate that Cdc42 and Merlin (show NF2 Proteins) act together with Pak1 (show PAK1 Proteins) to control salivary gland lumen size.

  10. Drosophila Rich (dRich), a conserved Cdc42-selective guanosine triphosphatase-activating protein (GAP), inhibits the Cdc42-Wsp pathway to stimulate postsynaptic Gbb release

Pig (Porcine) Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. Hypoxic pulmonary arterial myocytes challenged with a thromboxane mimetic polymerize actin via the Cdc42 pathway, reflecting increased Cdc42 association with neuronal Wiskott Aldrich Syndrome protein.

  2. Cdc42 is involved in the regulation of alppha-smooth muscle actin promoter activation through p21 (show CDKN1A Proteins)-activated kinase, p38 (show MAPK14 Proteins), myocardin-related transcription factor and serum response factor. Cdc42 may be an important regulator of MRTF cellular localization

Human Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. we found that CXCR4 (show CXCR4 Proteins)-CXCL12 (show CXCL12 Proteins)/AKT (show AKT1 Proteins) axis regulates RhoA (show RHOA Proteins), Rac-1, and Cdc42 to modulate cell invasion and tumor metastasis. Together, these results demonstrate a role for CXCR4 (show CXCR4 Proteins) in ESCC metastasis and progression and suggest potential targets for therapeutic intervention.

  2. Low gene dosage of cdc42 is not associated with protein dysfunction in patients with colorectal cancer.

  3. We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1 (show FARP1 Proteins), ARHGEF1 (show ARHGEF1 Proteins), and ARHGAP36 (show ARHGAP36 Proteins)

  4. PAK6 (show PAK6 Proteins) localization to cell-cell adhesions is Cdc42-dependent

  5. Golgi-localized Cdc42 enables the cell to diversify the function of Cdc42, which in some cases represents new roles and in other cases acts to complement the established roles of Cdc42 at the plasma membrane.

  6. The present observation provides further evidence supporting the notion that a mutation in CDC42 causes a recognizable syndromic form of thrombocytopenia.

  7. the Cdc42/Nwasp (show WASL Proteins)/stress fibers/YAP (show YAP1 Proteins) signal pathway may potentially play an important role in regulating podocyte apoptosis. Maintaining necessary Cdc42 would be one potent way to prevent proteinuria kidney diseases.

  8. we identified Cdc42 as a potentially essential biomarker for trichohepatoenteric syndrome

  9. we discovered distinct predictive performance of Rac1 and Cdc42 depending on the migration modes, indicating that Rac1 and Cdc42 contribute to persistent and random migration, respectively

  10. Authors conclude that a transient interaction between Cdc42 and GRAF1 (show ARHGAP26 Proteins) drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism.

Mouse (Murine) Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. presentation of a form of biochemical computation in dendrites involving the controlled complementation of three molecules--Rac1, RhoA (show RHOA Proteins) and Cdc42--that simultaneously ensures signal specificity and primes the system for BDNF (show BDNF Proteins)-dependent homo- and heterosynaptic plasticity

  2. Cdc42 is involved not in osteogenesis but in chondrogenesis in which the BMP2 (show BMP2 Proteins)/Cdc42/Pak/p38 (show CRK Proteins)/Smad (show SMAD1 Proteins) signaling module promotes mesenchymal condensation and the TGF-beta (show TGFB1 Proteins)/Cdc42/Pak/Akt (show AKT1 Proteins)/Sox9 (show SOX9 Proteins) signaling module facilitates chondrogenic differentiation.

  3. These data show that membrane protrusions originate from surface ectodermal cells and that Rac1 is necessary for the formation of membrane ruffles which typify late neural fold closure stages, whereas Cdc42 is required for the predominance of filopodia in early neurulation.

  4. findings demonstrate that Cdc42 plays essential roles in mammary gland function post pregnancy, where it helps to establish proper epithelial cell polarity and tissue homeostasis during lactation.

  5. This work demonstrated miR (show MLXIP Proteins)-137 and CDC42 are critical regulators in cardiomyocyte apoptosis.

  6. the principal role of Cdc42 in ureteric bud and metanephric mesenchyme development is to regulate epithelial cell polarity and the actin cytoskeleton.

  7. indicate that restricted expression of Wnt5a (show WNT5A Proteins) in the caudal SpM (show NPC1 Proteins) is essential for normal OFT morphogenesis, and uncover a novel function of spatially regulated cell cohesion by Wnt5a (show WNT5A Proteins) in driving the deployment of SHF (show SHF Proteins) cells from the SpM (show NPC1 Proteins) into the OFT

  8. role of P-cadherin through beta-PIX (show ARHGEF7 Proteins)-mediated Cdc42 activation in the regulation of cell polarity

  9. Thus, Cdc42 and Rac1 have nonredundant roles in controlling ALK-rearranged lymphoma survival and morphology but are redundant for lymphoma dissemination

  10. Knockdown of Fat1 in renal tubular cells decreases active RAC1 and CDC42.

Cow (Bovine) Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex.

  2. This study revealed a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell.

  3. These data are consistent with the idea that migrating corneal epithelial cells use a cdc42/rho "switch" to sort vectoral cues, with cdc42 controlling electrotaxis and rho controlling contact guidance.

Candida albicans Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) interaction partners

  1. Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.

  2. These results suggest the development of hyphal-specific characteristics is promoted by Cdc42-GTP (show AK3 Proteins) in a process that also requires the intrinsic GTPase (show RACGAP1 Proteins) activity of Cdc42.

CDC42 Protein Profile

Protein Summary

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.

Alternative names and synonyms associated with CDC42

  • cell division cycle 42 (cdc42)
  • CG12530 gene product from transcript CG12530-RC (Cdc42)
  • cell division cycle 42 (CDC42)
  • cell division cycle 42, like (cdc42l)
  • Cell division control protein 42 homolog (CDC42)
  • cell division control protein 42 homolog (LOC100386331)
  • cell division control protein 42 homolog (LOC100392513)
  • cell division control protein 42 homolog (LOC100404291)
  • cell division control protein 42 homolog (LOC100424807)
  • cell division cycle 42 (GTP binding protein, 25kDa) (CDC42)
  • cell division control protein 42 homolog (LOC100455652)
  • cell division control protein 42 homolog (LOC100465076)
  • cell division control protein 42 homolog (LOC100627190)
  • cell division control protein 42 homolog (LOC100636735)
  • cell division control protein 42 homolog (LOC100637699)
  • cell division control protein 42 homolog (LOC100638834)
  • cell division cycle 42 (GTP binding protein, 25kDa) (TGas120g11.1)
  • cell division cycle 42 (Cdc42)
  • cell division cycle 42 (GTP binding protein) (Cdc42)
  • one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase; signal transduction (CDC42)
  • AI747189 protein
  • AU018915 protein
  • Cdc42 protein
  • cdc42a protein
  • Cdc42Dm protein
  • CDC42Hs protein
  • CG12530 protein
  • D-cdc42 protein
  • Dcdc42 protein
  • Dm Cdc42 protein
  • Dmcdc42 protein
  • Dmel\\CG12530 protein
  • G25K protein
  • wu:fb07d08 protein
  • wu:fi33d02 protein
  • wu:fj62g06 protein
  • Xcdc42 protein
  • zgc:55427 protein
  • zgc:63918 protein
  • zgc:86687 protein

Protein level used designations for CDC42

Cdc42 protein homolog , cell division control protein 42 homolog , fj62g06 , cell division cycle 42 (GTP binding protein, 25kDa) , CG12530-PA , CG12530-PB , CG12530-PC , CG12530-PD , CG12530-PE , CG12530-PF , Cdc42-PA , Cdc42-PB , Cdc42-PC , Cdc42-PD , Cdc42-PE , Cdc42-PF , Cdc42-like , cdc42c , cell division cycle 42 homolog , Cell division control protein 42 homolog , cell division control protein 42-like protein , G25K GTP-binding protein , GTP binding protein, 25kDa , GTP-binding protein, 25kD , dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) , dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) , growth-regulating protein , small GTP binding protein CDC42 , CDC42 GTP-binding protein , likely rho family Ras-like GTPase

336839 Danio rerio
379055 Xenopus laevis
32981 Drosophila melanogaster
745248 Pan troglodytes
793158 Danio rerio
4836688 Scheffersomyces stipitis CBS 6054
100386331 Callithrix jacchus
100392513 Callithrix jacchus
100404291 Callithrix jacchus
100424807 Macaca mulatta
100438199 Pongo abelii
100455652 Pongo abelii
100465076 Ailuropoda melanoleuca
100528978 Ictalurus punctatus
100627190 Sus scrofa
100636735 Amphimedon queenslandica
100637699 Amphimedon queenslandica
100638834 Amphimedon queenslandica
456609 Pan troglodytes
493389 Xenopus (Silurana) tropicalis
549824 Xenopus (Silurana) tropicalis
607535 Canis lupus familiaris
707637 Macaca mulatta
100227983 Taeniopygia guttata
998 Homo sapiens
12540 Mus musculus
395917 Gallus gallus
403934 Canis lupus familiaris
532712 Bos taurus
780428 Sus scrofa
64465 Rattus norvegicus
3646488 Candida albicans SC5314
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