CDC42 Protein (AA 1-188) (His tag)

Catalog No. ABIN7505004

Product Details

Target: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Protein Type: Recombinant

Protein Characteristics: AA 1-188

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CDC42 protein is labelled with His tag.

Sequence: Met1-Cys188

Characteristics: A DNA sequence encoding theHuman CDC42 protein (P60953-2) (Met1-Cys188) was expressed with a N-His.

Purity: >95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Alternative Name: CDC42 (CDC42 Products)

Synonyms: CDC42Hs Protein, G25K Protein, AI747189 Protein, AU018915 Protein, cdc42a Protein, wu:fb07d08 Protein, wu:fj62g06 Protein, zgc:63918 Protein, Xcdc42 Protein, cdc42hs Protein, g25k Protein, CDC42 Protein, CG12530 Protein, Cdc42Dm Protein, D-CDC42 Protein, D-Cdc42 Protein, D-cdc42 Protein, DCDC42 Protein, DCdc42 Protein, Dcdc42 Protein, Dm Cdc42 Protein, DmCDC42 Protein, Dmcdc42 Protein, Dmel\\CG12530 Protein, cdc42 Protein, cell division cycle 42 Protein, Cell division control protein 42 homolog Protein, cell division control protein 42 homolog Protein, cell division cycle 42 L homeolog Protein, CG12530 gene product from transcript CG12530-RC Protein, Rho family GTPase Protein, CDC42 Protein, Cdc42 Protein, cdc42 Protein, LOC100636735 Protein, LOC100637699 Protein, LOC100638834 Protein, cdc42.L Protein

Background:

Background: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase.Regulates cell migration.In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections.Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation.Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling.Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.

Synonym: G25K GTP-binding protein

Molecular Weight: 20.9 kDa

Pathways: MAPK Signaling, Microtubule Dynamics, RTK Signaling, WNT Signaling, TCR Signaling, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling