Browse our GJA1 Proteins (GJA1)

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Gap Junction Protein, alpha 1, 43kDa Proteins (GJA1)
On are 10 Gap Junction Protein, alpha 1, 43kDa (GJA1) Proteins from 3 different suppliers available. Additionally we are shipping GJA1 Antibodies (306) and GJA1 Kits (65) and many more products for this protein. A total of 395 GJA1 products are currently listed.
AI118175, AU042049, AVSD3, AW546267, Cnx32, Cnx43, Cnx46, connexin43, connexin 43, Cx32, CX43, cx43a1, Cx43alpha1, Cx46, DFNB38, Gja-1, Gja-3, gja1, gja1-A, GJAL, Gjb-1, HLHS1, HSS, Npm1, ODDD, zfCx43.3
list all proteins Gene Name GeneID UniProt
GJA1 14609 P23242
GJA1 24392 P08050
GJA1 2697 P17302

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GJA1 Proteins (GJA1) by Origin

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More Proteins for GJA1 Interaction Partners

Zebrafish Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.

  2. serpinh1b (show HSP47 Proteins) is molecularly and functionally downstream of cx43. The gene serpinh1b (show HSP47 Proteins) codes for a protein called Hsp47 (show HSP47 Proteins), a molecular chaperone (show HSP90AA1 Proteins) responsible for proper folding of procollagen molecules.

  3. Hapln1a (show HAPLN1 Proteins)-ECM (show MMRN1 Proteins) stabilizes the secreted growth factor (show WNT2 Proteins) Semaphorin3d (Sema3d (show SEMA3D Proteins)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.

  4. Hapln1a (show HAPLN1 Proteins) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton

  5. Sema3d (show SEMA3D Proteins) functions in a common molecular pathway with Cx43 cell proliferation and joint formation

  6. Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (show COL6A1 Proteins)) exhibited osteogenic characteristics, in which Cx43 played an important role.

  7. Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.

  8. Data demonstrate a cross-talk between IGF-1R (show IGF1R Proteins) and AT-1R in AT-II and IGF-1 (show IGF1 Proteins)-induced Cx43 expression in SV SMCs involving Erk 1 (show MAPK3 Proteins)/2 and downstream activation of the AP-1 (show JUN Proteins) transcription factor.

  9. Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (show GJC1 Proteins).

  10. Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.

Rabbit Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. These findings indicated that Cx43/miR (show MYLIP Proteins)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.

  2. Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.

  3. Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.

  4. In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart

Mouse (Murine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Blocking of connexin32 (show GJB1 Proteins) or connexin43 hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury.

  2. deletion of connexin 43 (Cx43, also known as GJA1) in astrocytes inhibits OPC proliferation by decreasing matrix glucose levels without impacting on OPC hemichannel properties, a process that also occurs in corpus callosum from acute brain slices.

  3. Relative to Gja1(+/-) controls, male Gja1(-/K258Stop) mice have a cortical bone phenotype that is remarkably similar to those reported for deletion of the entire Cx43 gene in osteoblasts.

  4. S368 of connexin 43 (also known as GJA1) is phosphorylated on gap junctions and connexosomes, whereas connexin 43 residue S262 is phosphorylated only on some connexosomes.

  5. a plaque accretion defect as the primary manifestation of myosin VI (show MYO6 Proteins) loss in Cx43 homeostasis, is reported.

  6. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.

  7. beige adipocytes display an increased cell-to-cell coupling via connexin 43 (Cx43) gap junction channels.

  8. intermittent hypoxia (but not sleep fragmentation) causes reductions and remodeling of atrial Cx40 (show GJA5 Proteins) and Cx43.

  9. the expression of Cx43 is specifically required in lymphatic endothelial cells for normal development of Lymphatic valves.

  10. This study showed that Gja1 may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 (show ACRV1 Proteins) on the differentiation of uterine stromal cells through targeting Hand2 (show HAND2 Proteins).

Guinea Pig Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.

  2. CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.

Cow (Bovine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.

  2. Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.

  3. RhoA (show RHOA Proteins) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress

  4. Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.

  5. Human TGF-beta1 (show TGFB1 Proteins) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells

  6. Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.

  7. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Proteins), Cx32 (show GJB1 Proteins), and Cx43

  8. CBN (show CALB1 Proteins) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.

  9. Results describe the effect of suppression of connexin 43 and E-cadherin (show CDH1 Proteins) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Human Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Cx45 (show GJC1 Proteins) mutant p.R75H is responsible for a novel disease entity of progressive atrial conduction system defects associated with craniofacial and dentodigital malformation.

  2. Connexin 43 expression is increased in human fetal membrane defects after fetoscopic surgery compared to controls, with preferential distribution in the fibroblast layer compared with the epithelial layer.

  3. Results show stark differences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phosphorylation, and hemichannel activity among Cx43 variants, as well as subtle differences in myofibroblast differentiation.

  4. These observations point to Cx43 as a novel profibrotic factor in asthma progression.

  5. results show that Cx43 expression is reduced in the diabetic retinas and Cx43 reduction is associated with increased vascular cell death; findings suggest that diabetes decreases retinal Cx43 expression and that the development of pericyte loss and acellular capilaries is associated with reduced Cx43 expression in diabetic retinopathy

  6. Reduced expression of Cx26 (show GJB2 Proteins) and Cx43 is implicated in the pathophysiology of colonic dysmotility in the aganglionic bowel as well as, in the case of Cx26 (show GJB2 Proteins), the ganglionic bowel in Hirschsprung's disease.

  7. Results suggest polymorphisms of Cx37 (show GJA4 Proteins) rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of essential hypertension.

  8. The Cx43 is the most prominent gap junction protein in the heart, cardiomyocyte-differentiated stem cells have been studied intensely. Cx43 expression was detected at mRNA and protein level in human cord-blood-derived induced pluripotent stem cells .

  9. Human deltoid muscle biopsies of 5 Chilean dysferlinopathy patients exhibited the presence of muscular connexins (Cx40.1, Cx43 and Cx45 (show GJC1 Proteins)).

  10. endogenous osteocyte Cx43 hemichannels emerge as important and promising therapeutic targets for the prevention of bone metastases and/or clinical treatment of bone-metastasized breast cancers

Pig (Porcine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.

  2. The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.

  3. we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.

  4. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (show CDK4 Proteins) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

  5. Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.

  6. Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.

  7. These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.

  8. Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.

  9. Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.

  10. During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.

GJA1 Protein Profile

Protein Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Alternative names and synonyms associated with GJA1

  • gap junction protein, alpha 1, 43kDa (gja1)
  • connexin 43 (cx43)
  • connexin 43 (CX43)
  • CONNEXIN 43 protein (CONNEXIN 43)
  • connexin 43-like (LOC100359132)
  • gap junction protein, alpha 1 (Gja1)
  • gap junction protein, alpha 1, 43kDa (GJA1)
  • gap junction protein, alpha 3 (Gja3)
  • gap junction protein, beta 1 (Gjb1)
  • AI118175 protein
  • AU042049 protein
  • AVSD3 protein
  • AW546267 protein
  • Cnx32 protein
  • Cnx43 protein
  • Cnx46 protein
  • connexin43 protein
  • connexin 43 protein
  • Cx32 protein
  • CX43 protein
  • cx43a1 protein
  • Cx43alpha1 protein
  • Cx46 protein
  • DFNB38 protein
  • Gja-1 protein
  • Gja-3 protein
  • gja1 protein
  • gja1-A protein
  • GJAL protein
  • Gjb-1 protein
  • HLHS1 protein
  • HSS protein
  • Npm1 protein
  • ODDD protein
  • zfCx43.3 protein

Protein level used designations for GJA1

alpha 1 gap junction protein , connexin 43 , connexin-43 , etID309742.9 , gap junction alpha-1 protein , gap junction protein, alpha 1 , shf , short fin protein , sof , alpha 1 connexin , gap junction 43 kDa heart protein , gap junction membrane channel protein alpha 1 , cx43 , gap junction protein, alpha 1, 43 kD (connexin 43) , vascular smooth muscle connexin-43 , gap junction protein, alpha 1, 43kDa (connexin 43) , Connexin-43 , gap junction protein alpha 1 , gap junction protein, alpha 1, 43kDa , alpha 3 connexin , connexin-46 , gap junction alpha-3 protein , gap junction membrane channel protein alpha 3 , connexin 32 , connexin-32 , gap junction beta-1 protein , gap junction membrane channel protein beta 1

394450 Xenopus (Silurana) tropicalis
30236 Danio rerio
100067229 Equus caballus
443455 Ovis aries
100359132 Oryctolagus cuniculus
14609 Mus musculus
24392 Rattus norvegicus
100379273 Cavia porcellus
281193 Bos taurus
2697 Homo sapiens
403418 Canis lupus familiaris
100518636 Sus scrofa
100008935 Oryctolagus cuniculus
373664 Xenopus laevis
395278 Gallus gallus
443233 Ovis aries
101100211 Felis catus
14611 Mus musculus
14618 Mus musculus
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