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Browse our GJA1 Proteins (GJA1)

Full name:
Gap Junction Protein, alpha 1, 43kDa Proteins (GJA1)
On www.antibodies-online.com are 11 Gap Junction Protein, alpha 1, 43kDa (GJA1) Proteins from 4 different suppliers available. Additionally we are shipping GJA1 Antibodies (301) and GJA1 Kits (51) and many more products for this protein. A total of 378 GJA1 products are currently listed.
Synonyms:
AI118175, AU042049, AVSD3, AW546267, Cnx32, Cnx43, Cnx46, connexin43, connexin 43, Cx32, CX43, cx43a1, Cx43alpha1, Cx46, DFNB38, Gja-1, Gja-3, gja1, gja1-A, GJAL, Gjb-1, HLHS1, HSS, Npm1, ODDD, zfCx43.3
list all proteins Gene Name GeneID UniProt
GJA1 14609 P23242
GJA1 24392 P08050
GJA1 2697 P17302

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GJA1 Proteins (GJA1) by Origin

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More Proteins for GJA1 Interaction Partners

Zebrafish Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.

  2. serpinh1b (show HSP47 Proteins) is molecularly and functionally downstream of cx43. The gene serpinh1b (show HSP47 Proteins) codes for a protein called Hsp47 (show HSP47 Proteins), a molecular chaperone (show HSP90AA1 Proteins) responsible for proper folding of procollagen molecules.

  3. Hapln1a (show HAPLN1 Proteins)-ECM (show MMRN1 Proteins) stabilizes the secreted growth factor (show WNT2 Proteins) Semaphorin3d (Sema3d (show SEMA3D Proteins)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.

  4. Hapln1a (show HAPLN1 Proteins) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton

  5. Sema3d (show SEMA3D Proteins) functions in a common molecular pathway with Cx43 cell proliferation and joint formation

  6. Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (show COL6A1 Proteins)) exhibited osteogenic characteristics, in which Cx43 played an important role.

  7. Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.

  8. Data demonstrate a cross-talk between IGF-1R (show IGF1R Proteins) and AT-1R in AT-II and IGF-1 (show IGF1 Proteins)-induced Cx43 expression in SV SMCs involving Erk 1 (show MAPK3 Proteins)/2 and downstream activation of the AP-1 (show JUN Proteins) transcription factor.

  9. Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (show GJC1 Proteins).

  10. Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.

Rabbit Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.

  2. Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.

  3. In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart

Mouse (Murine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The results identify new protein-protein interactions between AIF (show AIFM1 Proteins)-Cx43, ETFB (show ETFB Proteins)-Cx43 and AIF (show AIFM1 Proteins)-ETFB (show ETFB Proteins) as possible players in the regulation of the mitochondrial redox state.

  2. Data show that in the presence of heterogeneous connexin 43 (Cx43) expression, ephaptic coupling can either prevent or promote conduction block (CB) depending on the Cx43 knockout (Cx43KO) content.

  3. Insulin (show INS Proteins) is cardioprotective against cryoinjury in diabetic mouse model and that this protection is associated with Cx43 gap junction function and phosphorylation in the mouse heart.

  4. Moderate intensity exercise produced significant cardiovascular benefits by improving mitochondrial function through restoration of Cx43 networks and mitochondrial trans-membrane potential and prevention of excessive mitochondrial fission.

  5. Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43

  6. Panx3 (show PANX3 Proteins) functions as an endoplasmic reticulum (ER) Ca(2 (show CA2 Proteins)+) channel to promote differentiation, and it could rescue mineralization defects in Cx43(-/-) calvarial cells.

  7. Study described a scrapie infection-mediated novel regulatory signaling pathway of Cx43 expression and may suggest a role for Cx43 in the pathogenesis of prion (show PRNP Proteins) diseases

  8. The results suggest an involvement of Cx43 in the psychosine-mediated apoptosis of primary oligodendrocyte progenitors from wild type or Krabbe disease twitcher (show GALC Proteins) mice.

  9. antigens present on bone marrowderived dendritic cell (BMDCs) can be suppressed by connexin43 knockdown in BMDCs.

  10. CX43 might represent an important regulator of dynamic Blood-testis barrier formation, composition and function.[review]

Guinea Pig Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.

  2. CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.

Cow (Bovine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.

  2. Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.

  3. RhoA (show RHOA Proteins) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress

  4. Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.

  5. Human TGF-beta1 (show TGFB1 Proteins) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells

  6. Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.

  7. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Proteins), Cx32 (show GJB1 Proteins), and Cx43

  8. CBN (show CALB1 Proteins) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.

  9. Results describe the effect of suppression of connexin 43 and E-cadherin (show CDH1 Proteins) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Human Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. AMPK (show PRKAA1 Proteins) inhibits Cx43 in BSMCs and improves bladder activity under pathological conditions. We propose that strategies that target AMPK (show PRKAA1 Proteins) can be developed as novel therapeutic approaches for treating bladder dysfunction.

  2. Cx43, which is up-regulated by mechanical stress, seems to function partly via the activation of ERK1/2 and p38 MAPK (show MAPK14 Proteins) signals to promote the osteoblastic differentiation of ligament fibroblasts.

  3. Cx43 expressed by mesenchymal stem cells induces apoptosis on leukemia cells.

  4. Report expression of connexin 43 in ovarian cancer cells in G1/S phase.

  5. Connexin 43 significantly regulates osteogenic differentiation in the cells from posterior longitudinal ligament by altering the activity of ERK (show EPHB2 Proteins), and subsequently causing the modification of Runx2 (show RUNX2 Proteins).

  6. Our data suggest a mechanism by which CT-Cx43 may regulate cell proliferation by regulating mir (show MLXIP Proteins)-125b and p53 (show TP53 Proteins) expression

  7. we are the first to identify that miR (show MLXIP Proteins)-381 suppresses C/EBPalpha (show CEBPA Proteins)-dependent Cx43 expression in breast cancer cells. The miR (show MLXIP Proteins)-381-C/EBPalpha (show CEBPA Proteins)-Cx43 axis might be a useful diagnostic and therapeutic target of metastatic breast cancer

  8. Cx43-Hsc70 (show HSPA8 Proteins) interaction regulates cell cycle G1/S progression through a novel mechanism by which Cx43-Hsc70 (show HSPA8 Proteins) interaction prevents the nuclear accumulation of p27 (show PAK2 Proteins) through controlling the nuclear translocation of cyclin D1 (show CCND1 Proteins)-CDK4 (show CDK4 Proteins)-p27 (show PAK2 Proteins) complex.

  9. local regulation of endothelial Cx43 expression within the vasculature regulates monocyteendothelial adhesion.

  10. demonstrate a specific role of the upstream DNA methylation (show HELLS Proteins)/miR (show MLXIP Proteins)-1298/Connexin 43 pathway in regulating VSMC function

Pig (Porcine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.

  2. we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.

  3. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (show CDK4 Proteins) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

  4. Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.

  5. Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.

  6. These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.

  7. Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.

  8. Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.

  9. During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.

  10. These results indicate that changes of Cx43 expression in the porcine myometrium during the oestrous cycle may be regulated by progesterone concentration and may contribute to the modulation of uterine motility.

GJA1 Protein Profile

Protein Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Alternative names and synonyms associated with GJA1

  • gap junction protein, alpha 1, 43kDa (gja1)
  • connexin 43 (cx43)
  • connexin 43 (CX43)
  • CONNEXIN 43 protein (CONNEXIN 43)
  • connexin 43-like (LOC100359132)
  • gap junction protein, alpha 1 (Gja1)
  • gap junction protein, alpha 1, 43kDa (GJA1)
  • gap junction protein, alpha 3 (Gja3)
  • gap junction protein, beta 1 (Gjb1)
  • AI118175 protein
  • AU042049 protein
  • AVSD3 protein
  • AW546267 protein
  • Cnx32 protein
  • Cnx43 protein
  • Cnx46 protein
  • connexin43 protein
  • connexin 43 protein
  • Cx32 protein
  • CX43 protein
  • cx43a1 protein
  • Cx43alpha1 protein
  • Cx46 protein
  • DFNB38 protein
  • Gja-1 protein
  • Gja-3 protein
  • gja1 protein
  • gja1-A protein
  • GJAL protein
  • Gjb-1 protein
  • HLHS1 protein
  • HSS protein
  • Npm1 protein
  • ODDD protein
  • zfCx43.3 protein

Protein level used designations for GJA1

alpha 1 gap junction protein , connexin 43 , connexin-43 , etID309742.9 , gap junction alpha-1 protein , gap junction protein, alpha 1 , shf , short fin protein , sof , alpha 1 connexin , gap junction 43 kDa heart protein , gap junction membrane channel protein alpha 1 , cx43 , gap junction protein, alpha 1, 43 kD (connexin 43) , vascular smooth muscle connexin-43 , gap junction protein, alpha 1, 43kDa (connexin 43) , Connexin-43 , gap junction protein alpha 1 , gap junction protein, alpha 1, 43kDa , alpha 3 connexin , connexin-46 , gap junction alpha-3 protein , gap junction membrane channel protein alpha 3 , connexin 32 , connexin-32 , gap junction beta-1 protein , gap junction membrane channel protein beta 1

GENE ID SPECIES
394450 Xenopus (Silurana) tropicalis
30236 Danio rerio
100067229 Equus caballus
443455 Ovis aries
100359132 Oryctolagus cuniculus
14609 Mus musculus
24392 Rattus norvegicus
100379273 Cavia porcellus
281193 Bos taurus
2697 Homo sapiens
403418 Canis lupus familiaris
100518636 Sus scrofa
100008935 Oryctolagus cuniculus
373664 Xenopus laevis
395278 Gallus gallus
443233 Ovis aries
101100211 Felis catus
14611 Mus musculus
14618 Mus musculus
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