Browse our JNK (MAPK8) ELISA Kits

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Mitogen-Activated Protein Kinase 8 ELISA Kits (MAPK8)
On are 27 Mitogen-Activated Protein Kinase 8 (MAPK8) ELISA Kits from 12 different suppliers available. Additionally we are shipping JNK Antibodies (432) and JNK Proteins (30) and many more products for this protein. A total of 523 JNK products are currently listed.
AI849689, Bsk, BSK/DJNK, c-Jun, CG5680, D-JNK, D-junk, DBSK/JNK, dJNK, DJNK/bsk, Dmel\\CG5680, jnk, JNK-46, JNK/SAPK, jnk1, JNK1A2, JNK21B1/2, Junk, mapk8, Prkm8, sapk1, SAPK1c, SAPKa, T10F20.15, zgc:112379
list all ELISA KIts Gene Name GeneID UniProt
MAPK8 5599 P45983
MAPK8 26419 Q91Y86
MAPK8 116554 P49185

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JNK (MAPK8) ELISA Kits by Reactivity

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Top referenced JNK ELISA Kits

  1. Human JNK ELISA Kit for Cell ELISA - ABIN1981833 : Hinton, Henderson, Blanks, Rudnicka, Miller: Monoclonal antibodies react with neuronal subpopulations in the human nervous system. in The Journal of comparative neurology 1988 (PubMed)
    Show all 9 references for 1981833

  2. ABIN411896 : Noguchi, Naziruddin, Shimoda, Fujita, Chujo, Takita, Peng, Sugimoto, Itoh, Tamura, Olsen, Kobayashi, Onaca, Levy, Matsumoto: Comparison of fresh and cultured islets from human and porcine pancreata. in Transplantation proceedings 2010 (PubMed)
    Show all 6 references for 411896

  3. ABIN411895 : Shintani, Hollingsworth, Wheelock, Johnson: Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. in Cancer research 2006 (PubMed)
    Show all 2 references for 411895

More ELISA Kits for JNK Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (show EGFR ELISA Kits)) pathway in the lateral epidermis for sustained dpp (show TGFb ELISA Kits) expression in the LE. Specifically, we demonstrate that Egfr (show EGFR ELISA Kits) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling

  2. n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing

  3. malignant transformation of the ras(V12)scrib(1 (show SCRIB ELISA Kits)) tumors requires bZIP protein Fos, the ETS (show ETS1 ELISA Kits)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 ELISA Kits), all acting downstream of Jun-N-terminal kinase.

  4. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  5. ROS (show ROS1 ELISA Kits)/JNK/p38 (show MAPK14 ELISA Kits)/Upd (show UROD ELISA Kits) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  6. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 ELISA Kits)-Src (show SRC ELISA Kits) synergy.

  7. This study demonstrated that the mechanism by which Bsk (show FRK ELISA Kits) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 ELISA Kits) Fasciclin II (show NCAM2 ELISA Kits) (FasII)

  8. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH ELISA Kits)-PNP (show NP ELISA Kits)) and magnesium.

  9. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.

  10. Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (show TARDBP ELISA Kits)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (show MAPK14 ELISA Kits) signaling dictates phenotypic outcome to TDP-43 (show TARDBP ELISA Kits) expression in Drosophila.

Human Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Taken together, our data demonstrate that JNK regulates triple-negative breast cancer (TNBC)tumorigenesis by promoting CSC phenotype through Notch1 (show NOTCH1 ELISA Kits) signaling via activation of c-Jun (show JUN ELISA Kits) and indicate that JNK/c-Jun/Notch1 (show NOTCH1 ELISA Kits) signaling is a potential therapeutic target for TNBC

  2. Here, the authors show that the CDK (show CDK4 ELISA Kits) inhibitor p21 (CDKN1A (show CDKN1A ELISA Kits)) maintains the viability of DNA damage-induced senescent cells. Upon p21 (show CDKN1A ELISA Kits) knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM (show ATM ELISA Kits)) and nuclear factor (NF)-kappaB (show NFKB1 ELISA Kits) kinase, leading to decreased cell survival. NF-kappaB (show NFKB1 ELISA Kits) activation induced TNF-alpha (show TNF ELISA Kits) secretion and JNK activation to mediate death of senescent cells in a...

  3. Results indicate that cordycepin promotes caveolin-1 (CAV1 (show CAV1 ELISA Kits))upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A (show FOXO3 ELISA Kits) protein (Foxo3a (show FOXO3 ELISA Kits)) signaling pathway activation, inducing apoptosis in lung cancer cells.

  4. The combination of 2-deoxyglucose (2-DG) and ABT-199 initiated cell death through the reduction of myeloid cell leukemia sequence 1 protein (Mcl-1 (show MCL1 ELISA Kits)) expression and c-Jun N-terminal kinase 1 (JNK1) activation and subsequent Bcl-xL (show BCL2L1 ELISA Kits) protein degradation.

  5. identified the c-Jun N-terminal kinase 1 (JNK1) as the kinase involved in the phosphorylation of NEIL1 (show NEIL1 ELISA Kits)

  6. This study suggests that advanced glycation end products (AGEs) and activation of AGEs receptor could induce the proliferation of smooth muscle cells from Saphenous vein but not smooth muscle cells from internal thoracic arteryvia MAP kinase (show MAPK1 ELISA Kits) pathway in diabetes mellitus.

  7. The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1 (show SP1 ELISA Kits)) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1 (show TGFB1 ELISA Kits)) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.

  8. JNK1 physically and functionally interacted with VDR (show CYP27B1 ELISA Kits) and positively regulated VDR (show CYP27B1 ELISA Kits) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.

  9. In conclusion, our findings revealed DIP2 (show WDR3 ELISA Kits) as a novel effector downstream of Bsk (show FRK ELISA Kits) modulating the direction of axon projection.

  10. The release of infectious respiratory syncytial virus (RSV) virions from infected cells was significantly reduced by JNK1/2 siRNA knockdown, implicating JNK1/2 as a key host factor for RSV virus production.

Mouse (Murine) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Study examined whether JNK is present at the presynaptic site and its activity after presynaptic NMDA receptors stimulation; found that JNK, via the JBD domain, acts as a physiological effector on T-SNARE (show VTI1B ELISA Kits) proteins; data suggest that JNK-dependent phosphorylation of T-SNARE (show VTI1B ELISA Kits) proteins may have an important functional role in synaptic plasticity.

  2. JNK signaling, which is inversely correlated with WNT4 (show WNT4 ELISA Kits), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin (show CDH1 ELISA Kits) junctions between oocytes in mouse ovaries.

  3. It was concluded that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.

  4. JNK1 activation suppresses antifungal immunity in mice. JNK1-deficient mice had a significantly higher survival rate than wild-type control mice in response to Candida albicans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect.

  5. activation of JNK in the endoplasmic reticulum stress response precedes activation of XBP1 (show XBP1 ELISA Kits).

  6. Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.

  7. JNK/FoxO1 (show FOXO1 ELISA Kits) is involved in the regulation of oxidative stress-induced (show SQSTM1 ELISA Kits) cell apoptosis in MGCs

  8. apoE (show APOE ELISA Kits)(-/-) mouse carrying a visceral fat graft from obese dnJNK donors were protected against enhanced systemic inflammation and atherogenesis.

  9. These data provide evidence for involvement of the TNF-alpha (show TNF ELISA Kits)-JNK axis in extracellular matrix remodeling.

  10. Phosphorylation levels of P38 (show CRK ELISA Kits) and JNK in siRNA-TMEM16A (show ANO1 ELISA Kits) group were lower than that of the Model group. Thus, TMEM16A (show ANO1 ELISA Kits) is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.

Xenopus laevis Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 ELISA Kits)-dependent Proteolysis of JNK1-2 and Bid (show BID ELISA Kits).

  2. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB ELISA Kits).

  3. Data show that the death pathway is independent of ERK (show MAPK1 ELISA Kits) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 ELISA Kits) and JNK.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 ELISA Kits))+ and ROS (show ROS1 ELISA Kits) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 ELISA Kits))+/CaMs and MAP kinase (show MAPK1 ELISA Kits) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 ELISA Kits) homeostasis

Zebrafish Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

  2. P38 (show MAPK14 ELISA Kits) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.

  3. A dorsalization pathway that is exerted by Axin (show AXIN1 ELISA Kits)/JNK signaling and its inhibitor Aida (show AIDA ELISA Kits) during vertebrate embryogenesis, is defined.

  4. JNK-Mmp13 (show MMP13 ELISA Kits) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Caenorhabditis elegans (C. elegans) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (show INS ELISA Kits)-IGF-1 (show IGF1 ELISA Kits) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi

  2. JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.

  3. The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.

  4. the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 ELISA Kits) (MAPK (show MAPK1 ELISA Kits)) signaling pathway, which is regulated by MLK-1 MAPK (show MAPK1 ELISA Kits) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 ELISA Kits) MAPK (show MAPK1 ELISA Kits) kinase (MAPKK), and KGB-1 (show KCNJ3 ELISA Kits) JNK-like MAPK (show MAPK1 ELISA Kits).

JNK (MAPK8) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with JNK (MAPK8)

  • basket (bsk) Elisa Kit
  • mitogen-activated protein kinase 8 (MAPK8) Elisa Kit
  • mitogen-activated protein kinase 8 (Mapk8) Elisa Kit
  • mitogen-activated protein kinase 8 (mapk8) Elisa Kit
  • mitogen-activated protein kinase 8 (ATMPK8) Elisa Kit
  • mitogen-activated protein kinase 8b (mapk8b) Elisa Kit
  • Protein JNK-1 (jnk-1) Elisa Kit
  • AI849689 Elisa Kit
  • Bsk Elisa Kit
  • BSK/DJNK Elisa Kit
  • c-Jun Elisa Kit
  • CG5680 Elisa Kit
  • D-JNK Elisa Kit
  • D-junk Elisa Kit
  • DBSK/JNK Elisa Kit
  • dJNK Elisa Kit
  • DJNK/bsk Elisa Kit
  • Dmel\\CG5680 Elisa Kit
  • jnk Elisa Kit
  • JNK-46 Elisa Kit
  • JNK/SAPK Elisa Kit
  • jnk1 Elisa Kit
  • JNK1A2 Elisa Kit
  • JNK21B1/2 Elisa Kit
  • Junk Elisa Kit
  • mapk8 Elisa Kit
  • Prkm8 Elisa Kit
  • sapk1 Elisa Kit
  • SAPK1c Elisa Kit
  • SAPKa Elisa Kit
  • T10F20.15 Elisa Kit
  • zgc:112379 Elisa Kit

Protein level used designations for MAPK8

CG5680-PB , CG5680-PE , CG5680-PF , JNK , JUN kinase , Jun N-terminal kinase , Jun NH2-terminal kinase , Jun-N-terminal kinase , Jun-kinase , bsk-PB , bsk-PE , bsk-PF , c-Jun N-terminal kinase , c-Jun aminoterminal kinase , c-Jun-N-terminal kinase , drosophila JNK , JUN N-terminal kinase , MAP kinase 8 , c-Jun N-terminal kinase 1 , mitogen-activated protein kinase 8 isoform JNK1 alpha1 , mitogen-activated protein kinase 8 isoform JNK1 beta2 , stress-activated protein kinase 1 , stress-activated protein kinase 1c , JNK1 beta1 protein kinase , MAPK 8 , mitogen activated protein kinase 8 , protein kinase mitogen-activated 8 , stress-activated protein kinase JNK1 , SAPK gamma , c-jun NH2-terminal kinase , p54 gamma , jnk1a-1 , mitogen-activated protein kinase 8

44801 Drosophila melanogaster
5599 Homo sapiens
26419 Mus musculus
116554 Rattus norvegicus
379876 Xenopus laevis
838394 Arabidopsis thaliana
65236 Danio rerio
177460 Caenorhabditis elegans
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