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Browse our MAP2K1 Proteins (MAP2K1)

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Mitogen-Activated Protein Kinase Kinase 1 Proteins (MAP2K1)
On are 22 Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Proteins from 9 different suppliers available. Additionally we are shipping MAP2K1 Antibodies (616) and MAP2K1 Kits (31) and many more products for this protein. A total of 708 MAP2K1 products are currently listed.
ATMEK1, CFC3, F20B18.180, F20B18_180, MAP kinase/ ERK kinase 1, MAPKK1, MEK, mek-2, MEK1, MEKK1, MITOGEN ACTIVATED PROTEIN KINASE KINASE, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, MKK1, NMAPKK, Prkmk1, si:ch211-242m18.2, wu:fj56a12, wu:fj61b01, zgc:56557
list all proteins Gene Name GeneID UniProt
MAP2K1 170851 Q01986
MAP2K1 5604 Q02750
MAP2K1 26395 P31938

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MAP2K1 Proteins (MAP2K1) by Origin

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Top referenced MAP2K1 Proteins

  1. Mouse (Murine) MAP2K1 Protein expressed in Baculovirus infected Insect Cells - ABIN3216428 : Duesbery, Webb, Leppla, Gordon, Klimpel, Copeland, Ahn, Oskarsson, Fukasawa, Paull, Vande Woude: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 4 references for ABIN3216428

More Proteins for MAP2K1 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation

  2. MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.

  3. The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.

  4. Data show that mitogen-activated protein kinase (show MAPK1 Proteins) kinases MEK1/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  5. the purpose of this paper was to investigate MAPK (show MAPK1 Proteins) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

  6. Specific inhibition of BRAF (show BRAF Proteins) oncogene (show RAB1A Proteins), MEK or p38 (show CRK Proteins) signaling was associated with decreases in DIO3 (show DIO3 Proteins) expression in papillary thyroid cancer cells

  7. Data show that Ba/F3 cells transformed with mutant HRAS (show HRAS Proteins) protien indicated equal sensitivity towards Map kinase (show MAPK1 Proteins) kinase (MEK) and mTOR (show FRAP1 Proteins) serine-threonine kinase (show TLK2 Proteins) (mTOR (show FRAP1 Proteins)) inhibition.

  8. Our data demonstrate that MEK inhibitors can inhibit breast cancer stem cells and may have clinical potential for the prevention of metastasis in certain cases in which tumors are MAPK (show MAPK1 Proteins) dependent.

  9. Data show that src (show SRC Proteins) kinases (SRC (show SRC Proteins)) and mitogen-activated protein kinase kinase 1 (MEK) co-inhibition by saracatinib and PD0325901 respectively can be broadly effective in tumor growth control of a wide panel of non-small cell lung cancer (NSCLC) cell lines.

  10. at clinically relevant concentrations, cDDP binds to and inhibits MEK1/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1/2

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. REDD1 (show DDIT4 Proteins) is required for normal insulin (show INS Proteins)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (show DDIT4 Proteins), and mTOR (show FRAP1 Proteins)

  2. blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (show LEPR Proteins) mice

  3. MEK1 and MEK2 (show MAP2K2 Proteins) can substitute for each other but a minimum amount of MEK (show MDK Proteins) is critical for placenta development and embryo survival

  4. Aberrant phosphorylation of AKT (show AKT1 Proteins) and MEK (show MDK Proteins) signalling pathways was identified in cells carrying mutant huntingtin (show HTT Proteins).

  5. An essential function for MEK1 in macrophages in regulating the ERK1/2 and STAT4 (show STAT4 Proteins) pathways in response to TLR4 (show TLR4 Proteins) activation.

  6. Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Proteins)), inhibiting adipogenesis and disrupting ERK (show EPHB2 Proteins) signaling.

  7. MEK1 is inhibited by phosphorylation at Thr (show TRH Proteins)-292/286 by Cdk5 (show CDK5 Proteins), ERK (show EPHB2 Proteins), and Cdk1 (show CDK1 Proteins).

  8. The effect of Akt1 (show AKT1 Proteins) and Mek1 on extracellular matrix synthesis was reconciled through the activation of p70 S6-kinase (show PRKACB Proteins).

  9. Homologous recombination efficiency enhanced by inhibition of MEK and GSK3beta.

  10. Data show that Treg cell-specific expression of activated MAP Kinase Kinase 1 (MEK1) led to dysregulation of Treg function.

Xenopus laevis Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. in FGFR1 (show FGFR1 Proteins) signalling JNK1 (show MAPK8 Proteins) phosphorylation depends on ERK2 (show MAPK1 Proteins)

  2. The data demonstrate that ERK (show MAPK1 Proteins) phosphorylation of UBF prevents DNA bending by its first two HMG (show SSRP1 Proteins) boxes, leading to a cooperative unfolding of the enhancesome

  3. We propose that Erk2 MAP kinase (show MAPK1 Proteins) phosphorylation of Vg1RBP (show IGF2BP3 Proteins) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.

Rabbit Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Extracellular signal-regulated kinase (ERK (show MAPK1 Proteins)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.

  2. KSR (show KSR1 Proteins) interacts with a regulatory Raf (show RAF1 Proteins) molecule in cis (show CISH Proteins) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 Proteins) molecule in trans

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Data indicate that MEKK2 (show MAP3K2 Proteins) is required for the mekk1 (show MAP3K1 Proteins), mkk1 mkk2 (show MAP2K2 Proteins), and mpk4 (show MAPK4 Proteins) autoimmune phenotypes.

  2. Data suggest that the MEKK1 (show MAP3K1 Proteins)-MKK1/MKK2 (show MAP2K2 Proteins)-MPK4 (show MAPK4 Proteins) kinase cascade negatively regulates MEKK2 (show MAP3K2 Proteins) and activation of MEKK2 (show MAP3K2 Proteins) triggers SUMM2-mediated immune responses.

  3. miR (show MYLIP Proteins)-1826 plays an important role as tumor suppressor via CTNNB1 (show CTNNB1 Proteins)/MEK1/VEGFC (show VEGFC Proteins) downregulation in bladder cancer.

  4. ETS1 (show ETS1 Proteins) is probably mediating high CIP2A (show KIAA1524 Proteins) expression in human cancers with increased EGFR (show EGFR Proteins)-MEK1/2-ERK (show MAPK1 Proteins) pathway activity

  5. An analysis of the interation of MEKK1 (show MAP3K1 Proteins) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.

  6. This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.

  7. These results suggest that the formation of SUMO-1 (show SUMO1 Proteins) foci is regulated by the MEK-ERK (show MAPK1 Proteins) pathway and may induce apoptosis.

  8. AtMEK1 is a crucial mediator in plant stress signal transduction.

  9. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (show MAP2K2 Proteins) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (show MAP3K1 Proteins) and mpk4 (show MAPK4 Proteins) mutants

  10. Activation of MPK4 (show MAPK4 Proteins) by flg22 is impaired in the mkk1 mkk2 (show MAP2K2 Proteins) double mutants, suggesting that MKK1 and MKK2 (show MAP2K2 Proteins) function together with MPK4 (show MAPK4 Proteins) and MEKK1 (show MAP3K1 Proteins) in a MAP kinase (show MAPK1 Proteins) cascade to negatively regulate innate immune responses in plants.

MAP2K1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Alternative names and synonyms associated with MAP2K1

  • mitogen activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (MAP2K1)
  • mitogen-activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (map2k1)
  • mitogen-activated protein kinase kinase 1 (MEK1)
  • ATMEK1 protein
  • CFC3 protein
  • F20B18.180 protein
  • F20B18_180 protein
  • MAP kinase/ ERK kinase 1 protein
  • MAPKK1 protein
  • MEK protein
  • mek-2 protein
  • MEK1 protein
  • MEKK1 protein
  • MKK1 protein
  • NMAPKK protein
  • Prkmk1 protein
  • si:ch211-242m18.2 protein
  • wu:fj56a12 protein
  • wu:fj61b01 protein
  • zgc:56557 protein

Protein level used designations for MAP2K1

ERK activator kinase 1 , MAP kinase kinase 1 , MAP kinase/Erk kinase 1 , MAPK/ERK kinase 1 , MAPKK 1 , dual specificity mitogen-activated protein kinase kinase 1 , mitogen-activated protein kinase kinase 1 , MEK 1 , protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) , dual specificity mitogen activated protein kinase kinase 1 , mitogen activated protein kinase kinase 1 , protein kinase, mitogen activated, kinase 1, p45 , MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2) , MEK1

170851 Rattus norvegicus
5604 Homo sapiens
478347 Canis lupus familiaris
26395 Mus musculus
379991 Xenopus laevis
415549 Gallus gallus
533199 Bos taurus
406728 Danio rerio
100009316 Oryctolagus cuniculus
100233191 Sus scrofa
828713 Arabidopsis thaliana
450188 Pan troglodytes
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