Browse our anti-MAP3K5 (MAP3K5) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 Antibodies (MAP3K5)
On www.antibodies-online.com are 389 Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Antibodies from 30 different suppliers available. Additionally we are shipping MAP3K5 Kits (39) and MAP3K5 Proteins (12) and many more products for this protein. A total of 467 MAP3K5 products are currently listed.
Synonyms:
7420452D20Rik, ASK, ASK1, MAP3K5, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11
list all antibodies Gene Name GeneID UniProt
MAP3K5 293015 O35099
MAP3K5 4217 Q99683

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Most Popular Reactivities for anti-MAP3K5 (MAP3K5) Antibodies

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anti-Mouse (Murine) MAP3K5 Antibodies:

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Top referenced anti-MAP3K5 Antibodies

  1. Human Polyclonal MAP3K5 Primary Antibody for WB - ABIN116930 : Matsuzawa, Ichijo: Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1. in Journal of biochemistry 2001 (PubMed)
    Show all 14 references for 116930

  2. Human Monoclonal MAP3K5 Primary Antibody for IF, WB - ABIN393594 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for 393594

  3. Human Polyclonal MAP3K5 Primary Antibody for IF, IHC (p) - ABIN197326 : Zhang, Zheng, Storz, Min: Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. in The Journal of biological chemistry 2005 (PubMed)
    Show all 4 references for 197326

  4. Human Polyclonal MAP3K5 Primary Antibody for IHC (p), WB - ABIN196914 : Fujii, Goldman, Park, Zhang, Chen, Fu: Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. in Oncogene 2004 (PubMed)
    Show all 4 references for 196914

  5. Human Polyclonal MAP3K5 Primary Antibody for IF, IHC (p) - ABIN197310 : Mabuchi, Ohmichi, Kimura, Nishio, Arimoto-Ishida, Yada-Hashimoto, Tasaka, Murata: Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. in Endocrinology 2003 (PubMed)
    Show all 3 references for 197310

  6. Human Polyclonal MAP3K5 Primary Antibody for IHC, ELISA - ABIN1531773 : Ichijo, Nishida, Irie, ten Dijke, Saitoh, Moriguchi, Takagi, Matsumoto, Miyazono, Gotoh: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. in Science (New York, N.Y.) 1997 (PubMed)
    Show all 2 references for 1531773

  7. Human Polyclonal MAP3K5 Primary Antibody for IHC (p), WB - ABIN196912 : Yuan, Feldman, Sussman, Coppola, Nicosia, Cheng: AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 196912

  8. Human Polyclonal MAP3K5 Primary Antibody for IHC, ELISA - ABIN1532802 : Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003 (PubMed)
    Show all 2 references for 1532802

  9. Human Polyclonal MAP3K5 Primary Antibody for IF (p), IHC (p) - ABIN683128 : Taniuchi, Furihata, Hanazaki, Iwasaki, Tanaka, Shimizu, Saito, Saibara: Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity. in Pancreas 2015 (PubMed)

More Antibodies against MAP3K5 Interaction Partners

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.

  2. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

  3. These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA (show F3 Antibodies)-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis.

  4. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Antibodies)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Antibodies) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

  5. ASK1 MAP kinase (show MAPK1 Antibodies) signaling cascade is an important regulator of chondrocyte terminal differentiation.

  6. ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.

  7. ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta (show TGFB1 Antibodies).

  8. ASK1 signalling regulates brown and beige (show LYST Antibodies) adipocyte function.

  9. blocking MPTP (show PTPN2 Antibodies)-mediated TNF (show TNF Antibodies) signaling through intrathecal administration of TNF (show TNF Antibodies)-neutralizing antibody prevented Trx1 (show TXN Antibodies) oxidation and downstream ASK1-p38 MAPK (show MAPK14 Antibodies) activation

  10. ASK1 deletion in vivo significantly suppresses hyperoxia-induced elevation of inflammatory cytokines (i.e. IL-1beta (show IL1B Antibodies) and TNF-alpha (show TNF Antibodies)), cell apoptosis in the lung, and recruitment of immune cells

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. PBL27 interacts with both CERK1 and the MAPK (show MAPK1 Antibodies) kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK (show MAPK1 Antibodies) kinase activation and disease resistance to Alternaria brassicicola.

Human Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

  1. CD40 (show CD40 Antibodies) activation resulted in down-regulation of Thioredoxin (Trx)-1 (show TXN Antibodies) to permit ASK1 activation and apoptosis. Although soluble receptor (show IFNAR1 Antibodies) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (show CD40 Antibodies) agonist and pharmacological inhibition of Trx-1 (show MLL Antibodies) was functionally equivalent to the signal triggered by mCD40L

  2. These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.

  3. from the two catalytic cysteines of TRX1 (show MLL Antibodies) the residue C32 (show CKLF Antibodies) is responsible for the high-affinity binding of TRX1 (show MLL Antibodies) to the ASK1-TRX (show VAC14 Antibodies)-binding domain in reducing conditions

  4. Shotgun mass spectrometry and manual validation identified 12 distinct ASK1 phosphosites. Targeted parallel reaction monitoring assays were used to track the phosphorylation dynamics of each confirmed site in response to treatment.

  5. phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta (show YWHAZ Antibodies) interacts with the kinase domain of ASK1 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.

  6. ASK1 MAP kinase (show MAPK1 Antibodies) signaling cascade is an important regulator of chondrocyte terminal differentiation.

  7. Pretreatment by IRE1 (show ERN1 Antibodies) agonist tunicamycin or JNK (show MAPK8 Antibodies) agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1 (show ERN1 Antibodies)-ASK1-JNK (show MAPK8 Antibodies) pathway

  8. Our results thus suggest that GSK-3beta (show GSK3b Antibodies) is a key factor involved in ASK1 activation and reactive oxygen species-induced cell death.

  9. the data show that miRNA-mediated down-regulation of ASK1 protects mesenchymal stem cells during post-transplantation, leading to an increase in the efficacy of MSC (show MSC Antibodies)-based cell therapy.

  10. Cross-talk between arginine methylation and serine phosphorylation in ASK1.PRMT5 (show PRMT5 Antibodies) is an ASK1-binding protein.PRMT5 mediates arginine methylation of ASK1.

MAP3K5 Antigen Profile

Antigen Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK.

Alternative names and synonyms associated with MAP3K5

  • mitogen-activated protein kinase kinase kinase 5 (Map3k5) antibody
  • mitogen-activated protein kinase kinase kinase 5 (MAPKKK5) antibody
  • mitogen-activated protein kinase kinase kinase 5 (MAP3K5) antibody
  • 7420452D20Rik antibody
  • ASK antibody
  • ASK1 antibody
  • MAP3K5 antibody
  • MAPKKK5 antibody
  • MEKK5 antibody
  • mitogen-activated protein kinase kinase kinase 5 antibody
  • MUD21.11 antibody
  • MUD21_11 antibody

Protein level used designations for MAP3K5

ASK-1 , MAPK/ERK kinase kinase 5 , MEK kinase 5 , MEKK 5 , apoptosis signal-regulating kinase 1 , mitogen activated protein kinase kinase kinase 5 , MAP/ERK kinase kinase 5 , apoptosis signal regulating kinase 1 , mitogen-activated protein kinase kinase kinase 5

GENE ID SPECIES
293015 Mus musculus
836819 Arabidopsis thaliana
4217 Homo sapiens
26408 Mus musculus
100157454 Sus scrofa
537380 Bos taurus
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