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anti-Human MAPK11 Antibodies:
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Human Polyclonal MAPK11 Primary Antibody for IHC - ABIN966524
Jiang, Chen, Li, Guo, Gegner, Lin, Han: Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). in The Journal of biological chemistry 1996
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Human Polyclonal MAPK11 Primary Antibody for IHC - ABIN966523
Kumar, McDonnell, Gum, Hand, Lee, Young: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. in Biochemical and biophysical research communications 1997
Show all 5 Pubmed References
Human Monoclonal MAPK11 Primary Antibody for ELISA, WB - ABIN969276
Beardmore, Hinton, Eftychi, Apostolaki, Armaka, Darragh, McIlrath, Carr, Armit, Clacher, Malone, Kollias, Arthur: Generation and characterization of p38beta (MAPK11) gene-targeted mice. in Molecular and cellular biology 2005
Show all 2 Pubmed References
Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis.
Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
These findings suggest that coronin 1A (show CORO1A Antibodies) modulates endothelial cell apoptosis by regulating p38beta expression and activation.
The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder.
p38beta is a novel regulatory target of the transcription factor Pokemon (show ZBTB7A Antibodies) and positively regulated by Pokemon (show ZBTB7A Antibodies) in hepatic cells.
Data show that the p38 MAPK (p38 (show MAPK14 Antibodies)) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell.
Differential roles for p38alpha (show MAPK14 Antibodies) and p38beta in the HGF (show HGF Antibodies)-induced expression of key osteogenic markers.
study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells
Study identifies Hsp27 (show HSPB1 Antibodies) as a novel target of ILK (show ILK Antibodies)-p38beta signaling complexes, playing a key role in bladder cancer cell migration.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 (show CCR7 Antibodies) signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional candidate gene
propose that active p38-Mapk14 (show MAPK14 Antibodies)/11 act as enablers, and Erk1/2 (show MAPK1/3 Antibodies) as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Double deficiency of p38alpha (show MAPK14 Antibodies) and p38beta in naive CD4 (show CD4 Antibodies)(+) T cells resulted in an attenuation of MAPK (show MAPK1 Antibodies)-activated protein kinase (show CDK7 Antibodies) (MK)-dependent mTOR (show FRAP1 Antibodies) signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Data indicate that alternatively activated p38alpha (show MAPK14 Antibodies) and p38beta up-regulates the transcription factors NFATc1 (show NFATC1 Antibodies) and IRF4 (show IRF4 Antibodies).
the cell autonomous defect in self-renewal in satellite cells from aged mice is due to an impaired response to FGF ligands and elevated p38alpha (show MAPK14 Antibodies)/beta MAPK (show MAPK1 Antibodies) activity
work reveals a 'seed and soil' mechanism where TGF-beta2 (show TGFB2 Antibodies) and TGF-beta (show TGFB1 Antibodies)-RIII signalling through p38alpha (show MAPK14 Antibodies)/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
Results suggest that UBR2 (show UBR2 Antibodies) up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta (show CEBPB Antibodies) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
inhibition of the SOCE downstream target CaM kinase kinase beta (show CAMKK2 Antibodies) (CaMKKbeta) or knockdown of AMPKalpha1 (show PRKAA1 Antibodies) suppressed PAR-1 (show MARK2 Antibodies)-mediated phosphorylation of p38beta and hence STIM1 (show STIM1 Antibodies).
p27 (show CDKN1B Antibodies) inhibition of COX-2 (show COX2 Antibodies) expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB (show CREB1 Antibodies)) phosphorylation mediated by p38beta and p38delta (show MAPK1/3 Antibodies).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
mitogen-activated protein kinase 11
, mitogen-activated protein kinase 11-like
, MAP kinase 11
, MAP kinase p38 beta
, MAPK 11
, mitogen-activated protein kinase p38 beta
, mitogen-activated protein kinase p38-2
, stress-activated protein kinase 2
, stress-activated protein kinase 2b
, stress-activated protein kinase-2
, stress-activated protein kinase-2b
, mitogen activated protein kinase 11
, protein kinase, mitogen activated kinase, 11, p38beta