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MAP3K4 Antibodies

(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
MAP3K4 antibody MAP3K4 antibody MAP3K4 antibody (ABIN7268653)

MAP3K4 Reactivity: Human IHC, WB Host: Rabbit Monoclonal unconjugated

MAP3K4 antibody  (AA 1-100) MAP3K4 antibody  (AA 1-100) MAP3K4 antibody (AA 1-100) (ABIN7268654)

MAP3K4 Reactivity: Human IHC, WB Host: Rabbit Polyclonal unconjugated

MAP3K4 antibody  (AA 1201-1300) MAP3K4 antibody  (AA 1201-1300) MAP3K4 antibody (AA 1201-1300) (ABIN561801)

MAP3K4 Reactivity: Human IHC (p), ELISA, WB Host: Mouse Monoclonal 4F10 unconjugated

MAP3K4 Antibodies by Reactivity

Find MAP3K4 Antibodies for a variety of species such as anti-Human MAP3K4, anti-Mouse MAP3K4, anti-Rat MAP3K4. The species listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 Antibodies by Application

Find MAP3K4 Antibodies validated for a specific application such as ELISA, WB, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

MAP3K4 Antibodies by Host

Find MAP3K4 Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 Antibodies by Binding Specificity

Find MAP3K4 Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 Antibodies by Clonality

Find available monoclonal or polyclonal MAP3K4 Antibodies. Click on a link to go to the corresponding products.

MAP3K4 Antibodies by Clone

Find MAP3K4 Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 Antibodies by Conjugate

Find MAP3K4 Antibodies with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MAP3K4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (5)
Cat. No. ABIN7268653
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (4)
Cat. No. ABIN7268654
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC (p), ELISA, WB
Validations
  • (4)
Cat. No. ABIN561801
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application PLA, ELISA, WB
Validations
  • (3)
Cat. No. ABIN561800
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7160041
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB
Validations
  • (2)
Cat. No. ABIN7300964
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN1327304
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application IHC (p), WB
Validations
  • (2)
Cat. No. ABIN5534485
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN953298
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (1)
Cat. No. ABIN6263107
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC, ELISA
Validations
  • (1)
Cat. No. ABIN1534230
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
Cat. No. ABIN7185125
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC (p)
Validations
Cat. No. ABIN6285739
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7160044
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7160043
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MAP3K4 Antibodies

Wong, Luo, Deng, Zou, Ye, Lin: "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39366-73, (2004) (PubMed).

Luo, Ng, Jin, Ye, Han, Lin: "Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37451-8, (2003) (PubMed).

Kovalsky, Lung, Roller, Fornace: "Oligomerization of human Gadd45a protein." in: The Journal of biological chemistry, Vol. 276, Issue 42, pp. 39330-9, (2001) (PubMed).

Aliases for MAP3K4 Antibodies

mitogen activated protein kinase kinase kinase 4 (Map3k4) Antibodies
mitogen-activated protein kinase kinase kinase 4 (MAP3K4) Antibodies
mitogen-activated protein kinase kinase kinase 4 (Map3k4) Antibodies
D17Rp17 Antibodies
D17Rp17e Antibodies
MAPKKK4 Antibodies
Mek4b Antibodies
MEKK4 Antibodies
MEKK 4 Antibodies
Mekk4 Antibodies
mKIAA0213 Antibodies
MTK1 Antibodies
PRO0412 Antibodies
RP17 Antibodies
Rp17a Antibodies
Tas Antibodies
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