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anti-Human MAPK3 Antibodies:
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
Show all 6 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
Show all 6 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967700
Ackerley, Grierson, Brownlees, Thornhill, Anderton, Leigh, Shaw, Miller: Glutamate slows axonal transport of neurofilaments in transfected neurons. in The Journal of cell biology 2000
Show all 5 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967701
Aguirre-Ghiso, Liu, Mignatti, Kovalski, Ossowski: Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. in Molecular biology of the cell 2001
Show all 5 Pubmed References
Chicken Polyclonal MAPK3 Primary Antibody for ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
Show all 9 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
Show all 4 Pubmed References
Mouse (Murine) Polyclonal MAPK3 Primary Antibody for IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
Show all 3 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
Show all 2 Pubmed References
Human Monoclonal MAPK3 Primary Antibody for WB - ABIN1539804
Lei, Chen, Huang, Wu, Lin, Lai: Proteomic analysis of the effect of extracellular calcium ions on human mesenchymal stem cells: Implications for bone tissue engineering. in Chemico-biological interactions 2015
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (show MAPK6 Antibodies) can both interact with SPOROCYTELESS/NOZZLE (SPL (show SGPL1 Antibodies)) in vitro and in vivo and can phosphorylate the SPL (show SGPL1 Antibodies) protein in vitro.
MKK4 (show MAP2K4 Antibodies), MKK5 (show MAP2K5 Antibodies), MKK7 (show MAP2K7 Antibodies), and MKK9, are responsible for the activation of MPK3 and MPK6 (show MAPK6 Antibodies) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Antibodies) signaling through MKK4 (show MAP2K4 Antibodies)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (show MAPK6 Antibodies), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (show MAPK6 Antibodies) to riboflavin-induced resistance.
These results indicate that the MVB pathway is positively regulated by pathogen-responsive MPK3/6 through LIP5 phosphorylation and plays a critical role in plant immune system
MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.
MPK3 and MPK6 (show MAPK6 Antibodies) target a subclass of 'VQ-motif'-containing proteins to regulate immune responses.
MicroRNA biogenesis factor DRB1 (show EPHX1 Antibodies) is a phosphorylation target of mitogen activated protein kinase (show MAPK1 Antibodies) MPK3 in both rice and Arabidopsis
MPK3 represses the constitutive and flg22-induced expression of defence genes in Arabidopsis thaliana.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (show NPPC Antibodies) and this process is related to the EGFR (show EGFR Antibodies) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 (show EGR1 Antibodies) via activation of ERK1/2 (show MAPK1/3 Antibodies) and contributes to pulmonary vascular remodeling.
ER Ca(2 (show CA2 Antibodies)+) release enhances eNOS (show NOS3 Antibodies) Ser (show SIGLEC1 Antibodies)-635 phosphorylation and function via ERK1/2 (show MAPK1/3 Antibodies) activation.
Thrombospondin 1 (show THBS1 Antibodies), fibronectin (show FN1 Antibodies), and vitronectin (show VTN Antibodies) are differentially dependent upon RAS, ERK1/2 (show MAPK1/3 Antibodies), and p38 (show MAPK14 Antibodies) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1 (show GAB1 Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Antibodies) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (show AKT1 Antibodies), mTOR (show FRAP1 Antibodies), p70S6K (show RPS6KB1 Antibodies), and ERK1/2 (show MAPK1/3 Antibodies).
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (show MAPK1 Antibodies).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 (show MAPK1/3 Antibodies) dependent.
Results suggest that estrogen receptors and the ERK1/2 (show MAPK1/3 Antibodies) signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
The results suggest that the MPK-1 (show MAPK1 Antibodies)/ERK (show MAPK1 Antibodies) regulatory network, including FBF-1 (show FBF1 Antibodies), FBF-2, and LIP-1 (show CENPJ Antibodies), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (show FGFR3 Antibodies) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (show SUV420H1 Antibodies) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (show MAPK1 Antibodies) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (show CDC42 Antibodies) GTPase (show RACGAP1 Antibodies).
ERK1/2 (show MAPK1/3 Antibodies)-Akt1 (show AKT1 Antibodies) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (show SH3GL1 Antibodies) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (show MAPK1 Antibodies) pathway
ERK1 and ERK2 (show MAPK1 Antibodies) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (show HSPA1A Antibodies) in response to heat stress is dependent on ERK (show MAPK1 Antibodies) activation in Pac2 (show PSMG2 Antibodies) cells.
Data define distinct roles for ERK1 and ERK2 (show MAPK1 Antibodies) in developmental cell migration processes during zebrafish embryogenesis.
GLUL (show GLUL Antibodies) knockdown markedly inhibited the p38 MAPK (show MAPK14 Antibodies) and ERK1/ERK2 (show MAPK1 Antibodies) signaling pathways in cultured breast cancer cells and reduces their proliferation.
These results suggested that HOXB7 (show HOXB7 Antibodies) stimulates ERK1/2 (show MAPK1/3 Antibodies) phosphorylation and provided evidence that HOXB7 (show HOXB7 Antibodies), besides its role in transcriptional regulation, also promotes cell motility and invasiveness.
High ERK1 expression is associated with castration-resistant prostate cancer.
combined use of butyrate and highly specific Syk (show SYK Antibodies) inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk (show SYK Antibodies)- and ERK1/2 (show MAPK1/3 Antibodies)-dependent manner.
new findings indicating that canonical FGFR (show FGFR2 Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) signaling entrapped hBMSCs in a pre-committed state and arrested further maturation of committed precursors.
mutually exclusive transcriptional regulation by AP-1 (cjun (show JUN Antibodies)/cfos) and non-canonical NF-kappaB (show NFKB1 Antibodies) (RelB (show RELB Antibodies)/p52 (show FKBP4 Antibodies)) downstream of MEK (show MAP2K1 Antibodies)-ERK (show EPHB2 Antibodies) and NIK (show MAP3K14 Antibodies)-IKK-alpha (show CHUK Antibodies)-NF-kappaB2 (p100 (show CUX1 Antibodies)) phosphorylation, respectively was responsible for persistent Ccl20 (show CCL20 Antibodies) expression in the colonic cells.
LPS (show IRF6 Antibodies)-activated ERK1,2 was at least partly involved in the observed effects on periodontal ligament stem cell differentiation capacity, acquisition of myofibroblastic attributes, and changes of their immunomodulatory features.
The findings indicate that ERK (show EPHB2 Antibodies) and JNK (show MAPK8 Antibodies) signaling pathways, as well as NF-kappaB (show NFKB1 Antibodies)-mediated signaling are important contributors to the pathogenesis of Kashin-Beck disease.
The antitumor activity of scopoletin may be due to its strong anti-angiogenic effect, which may be mediated by its effective inhibition of ERK1, VEGF-A (show VEGFA Antibodies), and FGF-2 (show FGF2 Antibodies).
High ERK1 expression is associated with melanoma.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (show MAPK1 Antibodies) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (show CD44 Antibodies) expression, and increased CD44 (show CD44 Antibodies) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (show ICAM1 Antibodies) and VCAM-1 (show VCAM1 Antibodies) by activating the ERK1/2 (show MAPK1/3 Antibodies) pathway, resulting in the expression of ETB (show EDNRB Antibodies) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (show NFkBP65 Antibodies), ERK1, ERK2 (show MAPK1 Antibodies) and STAT1 (show STAT1 Antibodies) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (show KITLG Antibodies) signaling.
At low oxLDL levels LOX-1 (show OLR1 Antibodies) activates the protective Oct-1 (show POU2F1 Antibodies)/SIRT1 (show SIRT1 Antibodies) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (show MAPK1/3 Antibodies) pathway.
Studies indicate that progesterone receptor (show PGR Antibodies) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (show CXCL9 Antibodies)-6over) phosphatase and tensin homolog (show PTEN Antibodies) protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (show MAPK1/3 Antibodies) and its target genes.
Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
ERK1 underexpression is associated with obesity.
retinoschisin (show RS1 Antibodies) is a novel regulator of MAP kinase (show MAPK1 Antibodies) signalling and exerts an anti-apoptotic effect on retinal cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (show BCL2L11 Antibodies).
Treatment with ERK (show MAPK1 Antibodies) inhibitors or ERK1/2 (show MAPK1/3 Antibodies) knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 (show MAPK1/3 Antibodies) signaling, has a substantial impact on T cell behavior.
CSF2 (show CSF2 Antibodies) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 (show MAPK1/3 Antibodies) MAPK (show MAPK1 Antibodies)-dependent MTOR (show FRAP1 Antibodies) signal transduction cascades.
PGRN (show GRN Antibodies) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Antibodies) activation mediated PPARgamma (show PPARG Antibodies) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Antibodies)/ERK (show MAPK1 Antibodies)/TSC2 (show TSC2 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 (show MAPK1/3 Antibodies) and JNK1 (show MAPK8 Antibodies)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 (show MAPK1/3 Antibodies) and p38 MAPK (show MAPK14 Antibodies) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (show IGF1 Antibodies) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (show IGF1R Antibodies)
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
extracellular signal-regulated kinase 1
, likely protein kinase
, MAP kinase isoform p44
, MAPK 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, mitogen-activated protein kinase 3
, extracellular signal-regulated kinase-1