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High Mcl-1 levels enhanced mTOR (show FRAP1 ELISA Kits) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A ELISA Kits) T cells.
Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.
Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.
a mechanism of inverse coregulation between BECN1 (show BECN1 ELISA Kits) and MCL1 significantly contributes to their opposing roles in tumorigenesis
There is a non-redundant pathway linking IL-15 (show IL15 ELISA Kits) to Mcl1 in the maintenance of NK cells and innate immune responses in vivo.
Authors recognize MCL-1 as the essential survival factor required for conservation of the postnatal PMF (show PRB1 ELISA Kits) pool, growing follicle survival and effective oocyte mitochondrial function.
Tax (show CNTN2 ELISA Kits) interacted with and activated TRAF6 (show TRAF6 ELISA Kits), and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with lysine 63-linked polyubiquitin (show UBB ELISA Kits) chains
deletion of Mir155 prevents Fas (show FAS ELISA Kits)-induced hepatocyte apoptosis and liver injury through the up-regulation of Mcl1.
Inverse co-regulation of Beclin 1 (show BECN1 ELISA Kits) and Mcl-1 represents a mechanism of functional counteraction in cancer.
miR (show MLXIP ELISA Kits)-29a is involved in the pathogenesis of ulcerative colitis by regulating intestinal epithelial apoptosis via Mcl-1.
LA provoked a down regulation of two anti-apoptotic proteins, Mcl-1 and Bcl-xL (show BCL2L1 ELISA Kits) protein and a strong induction of the BH3-only (show BBC3 ELISA Kits) protein Bim (show BCL2L11 ELISA Kits).
AZD5582 draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 (show BIRC2 ELISA Kits) and XIAP (show XIAP ELISA Kits) in human pancreatic cancer
the FoxM1 (show FOXM1 ELISA Kits)/Mcl-1 pathway may overcome cispaltin resistance of gastric cancer and provide a new therapeutic target for the treatment of gastric cancer
Upregulation of miR (show MLXIP ELISA Kits)-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. miR (show MLXIP ELISA Kits)-125b elicits these responses by directly targeting MCL1, which results in a marked reduction in MCL1 expression.
In the acquired resistance setting, MCL1 suppression in response to HSP90 (show HSP90 ELISA Kits) inhibitors is maintained; however, a switch in MCL1 dependence occurs
The mechanisms involved in 17-DR-induced apoptosis included the downregulation of myeloid cell leukemia-1 (Mcl-1), and upregulation of Bcl-2 (show BCL2 ELISA Kits) antagonist killer 1 (Bak (show BAK1 ELISA Kits)).
Reduced miR (show MLXIP ELISA Kits)-512 and the elevated expression of its targets cFLIP (show CFLAR ELISA Kits) and MCL1 localize to neurons with hyperphosphorylated Tau protein in Alzheimer disease.
The authors now show that human cytomegalovirus more robustly upregulated Mcl-1 than normal myeloid growth factors and that Mcl-1 was the only myeloid survival factor to rapidly induce HSP27 (show HSPB1 ELISA Kits) prior to the 48-h cell fate checkpoint.
Data show that leukemia inhibitory factor (LIF (show LIF ELISA Kits)) signaling promote chemoresistance in cholangiocarcinoma by up-regulating myeloid cell factor-1 (Mcl-1) via phosphatidylinositol 3-kinase (PI3K (show PIK3CA ELISA Kits))/c-akt (show AKT1 ELISA Kits) protein (AKT (show AKT1 ELISA Kits))-dependent pathway.
Mcl-1 plays a fundamental role in the survival and resistance of U-937 cells to etoposide.
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog
, bcl-2-like protein 3
, induced myeloid leukemia cell differentiation protein Mcl-1
, myeloid cell leukemia ES
, myeloid cell leukemia protein 1