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Endothelial cell -specific deletion of Mcl1 resulted in a dose-dependent increase in endothelial cell apoptosis in the angiogenic vasculature and a corresponding decline in vessel density.
Our findings indicate that MCL-1 expression is an important biomarker of TEC (show NR4A3 ELISA Kits) survival
These results identify MCL-1 as a critical prosurvival protein for preventing beta-cell death and clarify the mechanisms behind its downregulation by proinflammatory cytokines.
These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells
BCL-XL (show BCL2L1 ELISA Kits) expression promotes survival of immature B cells, expression of BCL-2 (show BCL2 ELISA Kits) is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development.
miR (show MLXIP ELISA Kits)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.
GSK3B (show GSK3b ELISA Kits)-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.
Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 ELISA Kits) signaling pathway is the primary mediator of Mcl-1 expression.
MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell
Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A ELISA Kits) Proteins c-myc (show MYC ELISA Kits) overexpressing B cell progenitors.
sequestration of Bim (show BCL2L11 ELISA Kits) by Mcl-1 is a mechanism of intrinsic ABT-199 resistance and supports the clinical development of ABT-199 in combination with cytarabine or daunorubicin for the treatment of AML (show RUNX1 ELISA Kits).
Quinacrine and sorafenib inhibited expression of prosurvival MCL1.
Mcl-1 suppression was determined to play a critical role in mediating this enhancing effect.
The authors identified the apoptosis regulator Mcl-1 as a target that interacts with Chlamydia trachomatis Cdu1 and is stabilized by deubiquitination at the chlamydial inclusion.
geraniin retarded ovarian cancer growth and reduced expression of phospho-p65 (show GORASP1 ELISA Kits) and Mcl-1. Collectively, geraniin elicits growth suppression in ovarian cancer through inhibition of NF-kappaB (show NFKB1 ELISA Kits) and Mcl-1 and may provide therapeutic benefits for this malignancy.
Data show that Noxa (show PMAIP1 ELISA Kits)-mediated MCL-1 phosphorylation and degradation is regulated by CDK2 (show CDK2 ELISA Kits).
UMI-77 alone or in combination with TRAIL untethered pro-apoptotic Bcl-2 (show BCL2 ELISA Kits) proteins Bim (show BCL2L11 ELISA Kits) and Bak (show BAK1 ELISA Kits) from the sequestration of Mcl-1 and promoted the conformational activation of Bak (show BAK1 ELISA Kits).
Our results demonstrate that in placenta accreta, miR (show MLXIP ELISA Kits)-29a/b/c inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1.
PTBP1 (show PTBP1 ELISA Kits) is a novel regulator of MCL1 mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
our results provide new insights into the critical role of NCTD in suppressing Mcl-1 via epigenetic upregulation of miR (show MLXIP ELISA Kits)-320d, resulting in PCa (show FLVCR1 ELISA Kits) cell apoptosis
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog
, bcl-2-like protein 3
, induced myeloid leukemia cell differentiation protein Mcl-1
, myeloid cell leukemia ES
, myeloid cell leukemia protein 1