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P21-Activated Kinase 1 Proteins (PAK1)
On are 16 P21-Activated Kinase 1 (PAK1) Proteins from 7 different suppliers available. Additionally we are shipping PAK1 Antibodies (332) and PAK1 Kits (12) and many more products for this protein. A total of 374 PAK1 products are currently listed.
AW045634, pak, PAK-1, Paka, PAKalpha, X-PAK1, XPak1
list all proteins Gene Name GeneID UniProt
PAK1 5058 Q13153
PAK1 18479  
PAK1 29431 P35465

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PAK1 Proteins (PAK1) by Origin

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More Proteins for PAK1 Interaction Partners

Xenopus laevis P21-Activated Kinase 1 (PAK1) interaction partners

  1. results represent the first evidence that Pak1 links extracellular signals to the genetic cascade of transcription factors necessary for cranial neural crest specification

  2. These findings expand the role of phosphoinositides in kinase signaling and suggest how altered phosphoinositide metabolism may upregulate Pak1 activity in cancer cells.

  3. The data suggest that EphA4 activation sequesters active Cdc42 (show CDC42 Proteins) and in this way down-regulates cell-cell adhesion.

  4. Pak1 inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo.

Human P21-Activated Kinase 1 (PAK1) interaction partners

  1. Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ (show RHOJ Proteins) signaling halts the growth of BRAF (show BRAF Proteins) mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism

  2. these data strongly support a critical interplay between prolactin (show PRL Proteins) and estrogen via PAK1 and suggest that ligand-independent activation of ERalpha (show ESR1 Proteins) through prolactin (show PRL Proteins)/PAK1 may impart resistance to anti-estrogen therapies.

  3. Given the central role of p21-Activated kinase 1 (PAK1) in vital signaling pathways, studies suggest that clinical development of PAK1 inhibitors will require careful investigation of their safety and efficacy.

  4. These findings suggest that small-molecule inhibitors of Pak1 may have a therapeutic role in the ~25% of ovarian cancers characterized by PAK1 gene amplification.

  5. autocrine VEGF (show VEGFA Proteins) and IL-8 (show IL8 Proteins) promoted endothelial cell migration via the Src (show SRC Proteins)/Vav2/Rac1/PAK1 signaling pathway.

  6. These data provide insight into the mechanisms guiding PRL (show PRL Proteins)-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 in breast cancer metastasis.

  7. p120 (show HNRNPU Proteins) participates in the progress of gastric cancer through regulating Rac1 and Pak1.

  8. The role of PAK1 in cancer drug resistance in BRAF (show BRAF Proteins)-mutated cancer

  9. High p21-activated kinase 1 and cell division control protein 42 homolog (show CDC42 Proteins) expressions are closely related to the clinicopathological features and poor prognosis of cervical carcinoma, serving as unfavorable prognostic factors.

  10. miR7 (show LILRB1 Proteins) negatively regulates PAK1 protein expression but has no effect on PAK1 mRNA expression. Knockdown of PAK1 expression markedly suppressed thyroid cancer cell proliferation, migration and invasion.

Mouse (Murine) P21-Activated Kinase 1 (PAK1) interaction partners

  1. present work presents the correlation between DSCAM gene overexpression and a dysregulation of the PAK pathway, resulting in altered morphological parameters of neuronal plasticity in the trisomic cell line, namely decreased number and length of processes

  2. These results identify Pak1 and Pak2 (show PAK2 Proteins) as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (show CDH2 Proteins)/Cdo (show CDO1 Proteins)/Cdc42 (show CDC42 Proteins) signaling pathway.

  3. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.

  4. These results implicate PAK1 as a regulator of Pancreatic stellate cells activation, proliferation and apoptosis. Targeting stromal PAK1 could increase therapeutic response and survival of patients with pancreatic cancer.

  5. The authors conclude that PAK1, besides its role in virus entry, also plays a relevant role in vaccinia virus dissemination.

  6. PAK1 contributes to initiation of intestinal carcinogenesis

  7. Pak1 is essential for adaptive physiological exercise-induced cardiac remodelling and support previous evidence that demonstrates Pak1 signalling is important for cardiac growth and survival.

  8. Further investigations identified Pak1-ERM (show ETV5 Proteins) as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK (show MAPK14 Proteins) signaling ensures timely epithelial apoptotic death at postimplantation.

  9. Nischarin (show NISCH Proteins) inhibits neurite outgrowth by blocking PAK1 activation in neurons.

  10. results indicate that NCAM (show NCAM1 Proteins) is delivered to the cell surface through a kinesin-1-mediated transport mechanism in a PAK1-dependent manner.

Caenorhabditis elegans (C. elegans) P21-Activated Kinase 1 (PAK1) interaction partners

  1. FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms.

  2. PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan.

  3. Pak-1 interacts with Wnt (show WNT2 Proteins) signaling to regulate tissue polarity and gene expression.

  4. only PAK-1 functions in the GIT/PIX (show ARHGEF7 Proteins)/PAK pathway independently of RAC (show AKT1 Proteins)/CDC42 (show CDC42 Proteins) GTPases.

  5. Data show that combined loss of ROCK and PAK, or ROCK and MRCK (show CDC42BPA Proteins), completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK (show CDC42BPA Proteins).

PAK1 Protein Profile

Protein Summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PAK1

  • p21 protein (Cdc42/Rac)-activated kinase 1 (pak1)
  • p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1)
  • p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1)
  • Protein PAK-1 (pak-1)
  • AW045634 protein
  • pak protein
  • PAK-1 protein
  • Paka protein
  • PAKalpha protein
  • X-PAK1 protein
  • XPak1 protein

Protein level used designations for P21-Activated Kinase 1 Proteins (PAK1)

p21 GTPase-associated kinase 1 , p21-activated kinase 1 , p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) , putative CDKN1A-activated kinase 1 , STE20 homolog, yeast , alpha-PAK , p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) , p65-PAK , serine/threonine-protein kinase PAK 1 , CDC42/RAC effector kinase PAK-A , activated protein kinase alpha , PAK-1 , p21 (CDKN1A)-activated kinase 1 , p68-PAK , protein kinase MUK2

398126 Xenopus laevis
451439 Pan troglodytes
100190755 Taeniopygia guttata
5058 Homo sapiens
18479 Mus musculus
29431 Rattus norvegicus
607885 Canis lupus familiaris
533729 Bos taurus
180873 Caenorhabditis elegans
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