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Browse our PAK1 Proteins (PAK1)

Full name:
P21-Activated Kinase 1 Proteins (PAK1)
On are 16 P21-Activated Kinase 1 (PAK1) Proteins from 7 different suppliers available. Additionally we are shipping PAK1 Antibodies (330) and PAK1 Kits (12) and many more products for this protein. A total of 372 PAK1 products are currently listed.
AW045634, pak, PAK-1, Paka, PAKalpha, X-PAK1, XPak1
list all proteins Gene Name GeneID UniProt
PAK1 5058 Q13153
PAK1 18479  
PAK1 29431 P35465

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PAK1 Proteins (PAK1) by Origin

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Xenopus laevis P21-Activated Kinase 1 (PAK1) interaction partners

  1. results represent the first evidence that Pak1 links extracellular signals to the genetic cascade of transcription factors necessary for cranial neural crest specification

  2. These findings expand the role of phosphoinositides in kinase signaling and suggest how altered phosphoinositide metabolism may upregulate Pak1 activity in cancer cells.

  3. The data suggest that EphA4 activation sequesters active Cdc42 (show CDC42 Proteins) and in this way down-regulates cell-cell adhesion.

  4. Pak1 inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo.

Human P21-Activated Kinase 1 (PAK1) interaction partners

  1. Myricetin effectively suppressed the protein expression of p21-activated kinase 1 (PAK1).

  2. overexpression of PAK1, NEK6 (show NEK6 Proteins), AURKA (show AURKA Proteins), and AURKB (show AURKB Proteins) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.

  3. Pak1 expression is not associated with breast cancer recurrence and resistance to tamoxifen.

  4. 1alpha,25-Dihydroxy-Vitamin D3 leads to disruption of RAC1 and PAK1 activity with subsequent actin depolymerization of endometrial carcinoma cells.

  5. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS (show HRAS Proteins), PAK1 and MEN1 (show MEN1 Proteins)) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS.

  6. PAK1-cofilin (show CFL1 Proteins) phosphorylation mechanism to mediate lung adenocarcinoma cells migration promoted by apelin (show APLN Proteins)-13

  7. PAK-1 overexpression may be involved in colorectal carcinoma progression and could be considered an independent predictor of disease recurrence.

  8. Combination of a PAK1 inhibitor such as FRAX597 with cytotoxic chemotherapy deserves further study as a novel therapeutic approach to pancreatic cancer treatment.

  9. beta-elemene enhances radiosensitivity of gastric cancer cells by inhibiting Pak1 signaling.

  10. PAK1 nuclear translocation is ligand-dependent: only PRL (show PRL Proteins) but not E2 stimulated PAK1 nuclear translocation

Mouse (Murine) P21-Activated Kinase 1 (PAK1) interaction partners

  1. The authors conclude that PAK1, besides its role in virus entry, also plays a relevant role in vaccinia virus dissemination.

  2. PAK1 contributes to initiation of intestinal carcinogenesis

  3. Pak1 is essential for adaptive physiological exercise-induced cardiac remodelling and support previous evidence that demonstrates Pak1 signalling is important for cardiac growth and survival.

  4. Further investigations identified Pak1-ERM (show ETV5 Proteins) as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK (show MAPK14 Proteins) signaling ensures timely epithelial apoptotic death at postimplantation.

  5. Nischarin (show NISCH Proteins) inhibits neurite outgrowth by blocking PAK1 activation in neurons.

  6. results indicate that NCAM (show NCAM1 Proteins) is delivered to the cell surface through a kinesin-1-mediated transport mechanism in a PAK1-dependent manner.

  7. propose that by repressing Pak1 expression, Rb prevents Rac1 hyperactivity usually associated with cancer and related to cytoskeletal derangements that disrupt cell adhesion, consequently enhancing cancer cell migratory capacity

  8. Pak1 is an important factor in the initiation and progression of atherogenesis.

  9. miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  10. These results suggest that PAK1 regulates cortical development by promoting the proliferation of neural progenitor cells.

Caenorhabditis elegans (C. elegans) P21-Activated Kinase 1 (PAK1) interaction partners

  1. FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms.

  2. PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan.

  3. Pak-1 interacts with Wnt (show WNT2 Proteins) signaling to regulate tissue polarity and gene expression.

  4. only PAK-1 functions in the GIT/PIX (show ARHGEF7 Proteins)/PAK pathway independently of RAC (show AKT1 Proteins)/CDC42 (show CDC42 Proteins) GTPases.

  5. Data show that combined loss of ROCK and PAK, or ROCK and MRCK (show CDC42BPA Proteins), completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK (show CDC42BPA Proteins).

PAK1 Protein Profile

Protein Summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PAK1

  • p21 protein (Cdc42/Rac)-activated kinase 1 (pak1)
  • p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1)
  • p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1)
  • Protein PAK-1 (pak-1)
  • AW045634 protein
  • pak protein
  • PAK-1 protein
  • Paka protein
  • PAKalpha protein
  • X-PAK1 protein
  • XPak1 protein

Protein level used designations for P21-Activated Kinase 1 Proteins (PAK1)

p21 GTPase-associated kinase 1 , p21-activated kinase 1 , p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) , putative CDKN1A-activated kinase 1 , STE20 homolog, yeast , alpha-PAK , p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) , p65-PAK , serine/threonine-protein kinase PAK 1 , CDC42/RAC effector kinase PAK-A , activated protein kinase alpha , PAK-1 , p21 (CDKN1A)-activated kinase 1 , p68-PAK , protein kinase MUK2

398126 Xenopus laevis
451439 Pan troglodytes
100190755 Taeniopygia guttata
5058 Homo sapiens
18479 Mus musculus
29431 Rattus norvegicus
607885 Canis lupus familiaris
533729 Bos taurus
180873 Caenorhabditis elegans
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