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Browse our anti-SIRT1 (SIRT1) Antibodies

Full name:
anti-Sirtuin 1 Antibodies (SIRT1)
On www.antibodies-online.com are 307 Sirtuin 1 (SIRT1) Antibodies from 35 different suppliers available. Additionally we are shipping SIRT1 Kits (44) and SIRT1 Proteins (18) and many more products for this protein. A total of 376 SIRT1 products are currently listed.
Synonyms:
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all antibodies Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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Most Popular Reactivities for anti-SIRT1 (SIRT1) Antibodies

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anti-Mouse (Murine) SIRT1 Antibodies:

anti-Human SIRT1 Antibodies:

anti-Rat (Rattus) SIRT1 Antibodies:

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Top referenced anti-SIRT1 Antibodies

  1. Human Monoclonal SIRT1 Primary Antibody for WB - ABIN1882053 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN1882053

  2. Cow (Bovine) Polyclonal SIRT1 Primary Antibody for WB - ABIN2779607 : Solomon, Pasupuleti, Xu, McDonagh, Curtis, DiStefano, Huber: Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for ABIN2779607

  3. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN745658 : Suzuki, Bartlett: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. in Biochimica et biophysica acta 2014 (PubMed)
    Show all 2 references for ABIN745658

  4. Human Monoclonal SIRT1 Primary Antibody for ICC, FACS - ABIN969396 : Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN969396

  5. Mouse (Murine) Polyclonal SIRT1 Primary Antibody for ELISA, WB - ABIN185702 : Chen, Steele, Lindquist, Guarente: Increase in activity during calorie restriction requires Sirt1. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for ABIN185702

  6. Human Monoclonal SIRT1 Primary Antibody for ICC, IF - ABIN2668278 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)
    Show all 2 references for ABIN2668278

  7. Human Monoclonal SIRT1 Primary Antibody for ELISA, FACS - ABIN4353901 : Lo Iacono, Visco-Comandini, Valzania, Viscomi, Coviello, Giampà, Roscini, Bisicchia, Siracusano, Troisi, Puglisi-Allegra, Carola: Adversity in childhood and depression: linked through SIRT1. in Translational psychiatry 2015 (PubMed)

  8. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN729853 : Mohan, Kumar, Lackner, Alvarez: Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. in Journal of immunology (Baltimore, Md. : 1950) 2014 (PubMed)

More Antibodies against SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Antibodies) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Antibodies) reduction and telomeric DNA damage.

  2. this study shows that the expression of SIRT1 is decreased in sepsis; SIRT1 functions as a negative regulator of pro-inflammatory cytokines

  3. Hepatic G6Pase-alpha (show G6PC Antibodies) deficiency leads to reduced expression of SIRT1. Downregulation of SIRT1 signaling impairs autophagy.

  4. AMPK (show PRKAA1 Antibodies) phosphorylation of cortactin (show CTTN Antibodies) followed by SIRT1 deacetylation modulates the interaction of cortactin (show CTTN Antibodies) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Antibodies)/SIRT1 coregulated cortactin (show CTTN Antibodies)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Antibodies) subcellular translocation/activation and is atheroprotective

  5. Activation of alpha7nAChR alleviates Ang II (show AGT Antibodies)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 pathway.

  6. data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1 (show SP1 Antibodies)/SIRT1 signaling pathway.

  7. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc (show SHC1 Antibodies) to upregulate endothelial miR (show MLXIP Antibodies)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1.

  8. Data demonstrate that CLOCK and BMAL1 (show ARNTL Antibodies) regulate muscle insulin (show INS Antibodies) sensitivity via SIRT1, and activation of SIRT1 might be a potential valuable strategy to attenuate muscle insulin (show INS Antibodies) resistance related to circadian misalignment.

  9. NAMPT (show NAMPT Antibodies) inhibited endothelial progenitor cell senescence through an SIRT1 AS lncRNA/miR (show MLXIP Antibodies)-22/SIRT1 pathway

  10. this study shows that fisetin exerts anti-inflammatory effects and attenuates the progression of osteoarthritis through activating SIRT1

Human Sirtuin 1 (SIRT1) interaction partners

  1. in chronic hyperoxia, SIRT1 promotes hyperoxia-induced lung epithelial cell damage and death by altering pro- and antiapoptotic balance, not by dampening optimal NRF2 (show GABPA Antibodies)-dependent antioxidant enxyme expression.

  2. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Antibodies) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Antibodies) reduction and telomeric DNA damage.

  3. our results showed that the expression and activity of SIRT1 are decreased in PASMCs exposed to H/R.

  4. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 Antibodies)/EGR1 (show EGR1 Antibodies)/SIRT1 signaling, and AKT (show AKT1 Antibodies) and p300 (show EP300 Antibodies) negatively regulate this process via Bim (show BCL2L11 Antibodies) upregulation.

  5. AMPK (show PRKAA1 Antibodies) phosphorylation of cortactin (show CTTN Antibodies) followed by SIRT1 deacetylation modulates the interaction of cortactin (show CTTN Antibodies) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Antibodies)/SIRT1 coregulated cortactin (show CTTN Antibodies)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Antibodies) subcellular translocation/activation and is atheroprotective

  6. Activation of alpha7nAChR alleviates Ang II (show AGT Antibodies)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 pathway.

  7. Structural features important for SIRT1 activation.

  8. SIRT1 predominantly localizes to the nucleus in cancer cells.

  9. A potential mechanism for the role of Sirt1 in lung fibrosis was through regulating the expression of p300 (show EP300 Antibodies). Thus, we characterized Sirt1 as an important regulator of lung fibrosis and provides a proof of principle for activation or overexpression of Sirt1 as a potential novel therapeutic strategy for IPF.

  10. the interplay between SIRT1 and HBx in the activation of hepatitis b virus transcription, is reported.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Antibodies) and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Antibodies) to that of ATGL (show PNPLA2 Antibodies) in adipocytes.

  5. CDK5 (show CDK5 Antibodies)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Antibodies).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Antibodies)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Antibodies) gene in adipocytes, and PPAR gamma (show PPARG Antibodies) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Antibodies) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Antibodies) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Antigen Profile

Antigen Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1) antibody
  • sirtuin 1 (SRT1) antibody
  • sirtuin 1 (LOC100349271) antibody
  • sirtuin 1 (Sirt1) antibody
  • sirtuin 1 (sirt1) antibody
  • AA673258 antibody
  • SIR2 antibody
  • Sir2a antibody
  • Sir2alpha antibody
  • sir2l1 antibody
  • sirtuin antibody
  • sirtuin 1 antibody

Protein level used designations for anti-Sirtuin 1 (SIRT1) Antibodies

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

GENE ID SPECIES
100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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