Browse our anti-SIRT1 (SIRT1) Antibodies

Full name:
anti-Sirtuin 1 Antibodies (SIRT1)
On are 328 Sirtuin 1 (SIRT1) Antibodies from 38 different suppliers available. Additionally we are shipping SIRT1 Kits (44) and SIRT1 Proteins (18) and many more products for this protein. A total of 397 SIRT1 products are currently listed.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all antibodies Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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Most Popular Reactivities for anti-SIRT1 (SIRT1) Antibodies

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anti-Mouse (Murine) SIRT1 Antibodies:

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anti-Rat (Rattus) SIRT1 Antibodies:

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Top referenced anti-SIRT1 Antibodies

  1. Cow (Bovine) Polyclonal SIRT1 Primary Antibody for WB - ABIN2779607 : Solomon, Pasupuleti, Xu, McDonagh, Curtis, DiStefano, Huber: Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. in Molecular and cellular biology 2005 (PubMed)
    Show all 6 references for 2779607

  2. Human Monoclonal SIRT1 Primary Antibody for WB - ABIN1882053 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for 1882053

  3. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN729853 : Mohan, Kumar, Lackner, Alvarez: Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. in Journal of immunology (Baltimore, Md. : 1950) 2014 (PubMed)
    Show all 3 references for 729853

  4. Human Monoclonal SIRT1 Primary Antibody for ICC, FACS - ABIN969396 : Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for 969396

  5. Human Monoclonal SIRT1 Primary Antibody for ICC, IF - ABIN2668278 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)
    Show all 2 references for 2668278

  6. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN745658 : Suzuki, Bartlett: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. in Biochimica et biophysica acta 2014 (PubMed)
    Show all 2 references for 745658

  7. Mouse (Murine) Polyclonal SIRT1 Primary Antibody for ELISA, WB - ABIN185702 : Chen, Steele, Lindquist, Guarente: Increase in activity during calorie restriction requires Sirt1. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for 185702

  8. Human Monoclonal SIRT1 Primary Antibody for ELISA, FACS - ABIN4353901 : Lo Iacono, Visco-Comandini, Valzania, Viscomi, Coviello, Giampà, Roscini, Bisicchia, Siracusano, Troisi, Puglisi-Allegra, Carola: Adversity in childhood and depression: linked through SIRT1. in Translational psychiatry 2015 (PubMed)

More Antibodies against SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.

  2. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. These findings suggest that adipocyte SIRT1 controls systemic glucose homeostasis and insulin (show INS Antibodies) sensitivity via the cross talk with adipose-resident macrophages.

  2. Posttraumatic inflammation plays a central role in regulating the pathogenesis of spinal cord injury (SCI). Here, new data show that administration of SRT1720, an SIRT1 agonist, to wild-type (WT) mice significantly improved outcomes after SCI, most likely by reducing the levels of inflammatory cytokines, the number of macrophages/microglia, perivascular macrophages, and M1 macrophages.

  3. Klotho (show KL Antibodies) deficiency down regulates SIRT1 activity in arterial endothelial cells and smooth muscle cells.

  4. Sirt1, by deacetylating Nav1.5 (show SCN5A Antibodies), plays an essential part in the regulation of INa (show INA Antibodies) and cardiac electrical activity. Cardiac Sirt1 deficiency in mice induces hyperacetylation of K1479 in Nav1.5 (show SCN5A Antibodies), decreases expression of Nav1.5 (show SCN5A Antibodies) on the cardiomyocyte membrane, reduces INa (show INA Antibodies) and leads to cardiac conduction abnormalities and premature death owing to arrhythmia.

  5. Suppression of Sirt1 or Foxo-1 (show FOXO1 Antibodies) expression significantly impaired exendin-4-induced adiponectin (show ADIPOQ Antibodies) expression. Consistently, exendin-4 up-regulated Sirt1 and Foxo-1 (show FOXO1 Antibodies) expression in vivo. Our work is the first study demonstrating the role of Sirt1/Foxo-1 (show FOXO1 Antibodies) in regulating the regulatory function of a GLP-1 receptor (show GLP1R Antibodies) agonist in adiponectin (show ADIPOQ Antibodies) expression both in vitro and in vivo.

  6. G004 is an efficient anti-atherosclerosis agent, improving vascular endothelial dysfunction by stimulating SIRT1/eNOS (show NOS3 Antibodies) and promoted reverse cholesterol transport by stimulating SIRT1/LXRalpha (show NR1H3 Antibodies)/ABCA1 (show ABCA1 Antibodies)/G1.

  7. miR (show MLXIP Antibodies)-34a-5p knockdown attenuates intestinal I/R injury through promoting SIRT1-mediated suppression of epithelial reactive oxygen species accumulation and apoptosis.

  8. these w-3 PUFAs may suppress neuroinflammation through SIRT1-mediated inhibition of the microglial NF-kappaB (show NFKB1 Antibodies) stress response and ensue pro-inflammatory cytokine release, which is implicated in NAMPT (show NAMPT Antibodies)-related and -unrelated pathways.

  9. The findings of this study suggesedt an important role for SIRT1 acting in the NAc (show NLRP1 Antibodies) in regulating mood disorders and present a novel path forward for the development of a new class of antidepressants targeting the sirtuin-signaling pathway.

  10. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Antibodies) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Antibodies) reduction and telomeric DNA damage.

Human Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via VDR (show CYP27B1 Antibodies) deacetylation.

  2. Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.

  3. SIRT1 single-nucleotide polymorphisms in older men may be more closely associated with nutrition and body composition than aging and age-related conditions.

  4. Our results provide evidence that all nutraceutical compounds have the potential to stimulate SIRT1 and sustain the stimulating action of resveratrol on SIRT1, already widely reported in the literature. We confirm the interaction of these substances also with the pathway of AMPK (show PRKAA1 Antibodies) and mTOR (show FRAP1 Antibodies), in support of the studies that highlight the importance of SIRT1/AMPK (show PRKAA1 Antibodies) and mTOR (show FRAP1 Antibodies) pathway in many diseases.

  5. Our data suggest that SIRT1 mRNA and H3K9me2 are potential biomarkers for evaluating multiple sclerosis patients' responsiveness to glatiramer acetate therapy in order to help guide treatment decisions in multiple sclerosis.

  6. miR (show MLXIP Antibodies)-34a/sirtuin-1/foxo3a (show FOXO3 Antibodies) might play an important role in genistein reversal of ox-LDL-induced oxidative damage in HUVECs.

  7. In conclusion, age-related decrease of SIRT1 expression in periferal blood mononuclear cells might in part result from overexpression of miR (show MLXIP Antibodies)-34a and miR (show MLXIP Antibodies)-9.

  8. SOX2 (show SOX2 Antibodies) is a main downstream regulator of SIRT1-mediated self-renewal and tumorigenicity potential of liver cancer stem cells

  9. Supplementation of omega-3 fatty acids in combination with vitamin E may have beneficial effects on coronary artery disease patients by increasing gene expression of SIRT1 and PGC1alpha and improving oxidative stress and inflammation in these patients.

  10. Data show that microRNA miR (show MLXIP Antibodies)-138-5p specifically targeted the sirtuin 1 (SIRT1) 3' untranslated region (3' UTR (show UTS2R Antibodies)) and suppressed autophagy by reducing the level of SIRT1.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Antibodies) and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Antibodies) to that of ATGL (show PNPLA2 Antibodies) in adipocytes.

  5. CDK5 (show CDK5 Antibodies)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Antibodies).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Antibodies)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Antibodies) gene in adipocytes, and PPAR gamma (show PPARG Antibodies) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Antibodies) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Antibodies) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Antigen Profile

Antigen Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1) antibody
  • sirtuin 1 (SRT1) antibody
  • sirtuin 1 (LOC100349271) antibody
  • sirtuin 1 (Sirt1) antibody
  • sirtuin 1 (sirt1) antibody
  • AA673258 antibody
  • SIR2 antibody
  • Sir2a antibody
  • Sir2alpha antibody
  • sir2l1 antibody
  • sirtuin antibody
  • sirtuin 1 antibody

Protein level used designations for anti-Sirtuin 1 (SIRT1) Antibodies

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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