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Browse our anti-SIRT1 (SIRT1) Antibodies

Full name:
anti-Sirtuin 1 Antibodies (SIRT1)
On are 310 Sirtuin 1 (SIRT1) Antibodies from 35 different suppliers available. Additionally we are shipping SIRT1 Kits (41) and SIRT1 Proteins (22) and many more products for this protein. A total of 380 SIRT1 products are currently listed.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
list all antibodies Gene Name GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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Most Popular Reactivities for anti-SIRT1 (SIRT1) Antibodies

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anti-Mouse (Murine) SIRT1 Antibodies:

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anti-Rat (Rattus) SIRT1 Antibodies:

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Top referenced anti-SIRT1 Antibodies

  1. Human Monoclonal SIRT1 Primary Antibody for WB - ABIN1882053 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for ABIN1882053

  2. Chicken Polyclonal SIRT1 Primary Antibody for WB - ABIN2779607 : Solomon, Pasupuleti, Xu, McDonagh, Curtis, DiStefano, Huber: Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for ABIN2779607

  3. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN745658 : Suzuki, Bartlett: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. in Biochimica et biophysica acta 2014 (PubMed)
    Show all 2 references for ABIN745658

  4. Human Monoclonal SIRT1 Primary Antibody for ICC, FACS - ABIN969396 : Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN969396

  5. Dog (Canine) Polyclonal SIRT1 Primary Antibody for WB - ABIN2779608 : Anavekar, Mirza, Skali, Plappert, St John Sutton, Pfeffer, Solomon,: Risk assessment in patients with depressed left ventricular function after myocardial infarction using the myocardial performance index--Survival and Ventricular Enlargement (SAVE) experience. in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2006 (PubMed)
    Show all 2 references for ABIN2779608

  6. Human Monoclonal SIRT1 Primary Antibody for ICC, IF - ABIN2668278 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)
    Show all 2 references for ABIN2668278

  7. Mouse (Murine) Polyclonal SIRT1 Primary Antibody for ELISA, WB - ABIN185702 : Chen, Steele, Lindquist, Guarente: Increase in activity during calorie restriction requires Sirt1. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for ABIN185702

  8. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN729853 : Mohan, Kumar, Lackner, Alvarez: Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. in Journal of immunology (Baltimore, Md. : 1950) 2014 (PubMed)

  9. Human Monoclonal SIRT1 Primary Antibody for ELISA, FACS - ABIN4353901 : Lo Iacono, Visco-Comandini, Valzania, Viscomi, Coviello, Giampà, Roscini, Bisicchia, Siracusano, Troisi, Puglisi-Allegra, Carola: Adversity in childhood and depression: linked through SIRT1. in Translational psychiatry 2015 (PubMed)

More Antibodies against SIRT1 Interaction Partners

Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. a potential role of SIRT1 in the regulation of chromatin structure and RNA processing

  2. Sirt1 overexpression could promote BaF3 cell proliferation, inhibit apoptosis, and upregulate pro-inflammatory cytokines.

  3. this study shows that inhibition of experimental autoimmune encephalomyelitis is associated with activation of AMPK (show PRKAA1 Antibodies)/SIRT1 signaling pathway

  4. emodin was found to increase the expression level of Sirt1, which decreased the level of deacetylated Smad3 (show SMAD3 Antibodies) to attenuate collagen deposition. Furthermore, the data suggested that there was direct binding between emodin and Sirt1. Sirt1regulated TGFb1 (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling was involved in silica inhalationinduced lung fibrosis.

  5. this study shows that the protective effect of rhapontin is from blocking the NLRP3 (show NLRP3 Antibodies) priming cascade reaction and is dependent on SIRT1 activation

  6. these results indicated that Sirt1 promotes the proliferation of C2C12 myoblast cells via the MSTN (show MSTN Antibodies) signaling pathway.

  7. SIRT1 gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 (show SREBF2 Antibodies) protein-mediated PI3K/AKT (show AKT1 Antibodies) signalling pathway, suggesting that SIRT1 gene may play a protective role against osteoarthritis.

  8. Sirtulin 1 (SIRT1), the mammalian homolog of yeast silent information regulator 2 (show SIRT2 Antibodies), is a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase and an important metabolic sensor in response to cellular energy status.

  9. Findings suggest a link between age-related cochlear hair cell apoptosis and microRNA miR (show MLXIP Antibodies)-29b/sirtuin 1 (SIRT1)/proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha) signaling, which may present an attractive pharmacological target for the development of novel drugs for the treatment of age-related hearing loss.

  10. this study shows that SIRT1-AMPK (show PRKAA1 Antibodies)-autophagy pathway may be involved in the maintenance of chronic inflammation and dysplasia development in the IL-10 (show IL10 Antibodies)-deficient mice model

Human Sirtuin 1 (SIRT1) interaction partners

  1. The findings of these studies suggested the potential involvement of SIRT1 in the pathogenesis of OA, and indicated that rutin is a possible therapeutic option for OA.

  2. Bioinformatics-based prediction, combined with qRT-PCR analysis and Western blotting, identified Onecut2 (show ONECUT2 Antibodies) and SIRT1 as the 2 prominent miR (show MLXIP Antibodies)-9 target genes under the conditions tested. In this study, Onecut2 (show ONECUT2 Antibodies) and SIRT1 were confirmed as miR (show MLXIP Antibodies)-9 target genes, which will help future investigations to probe in greater detail the role of miR (show MLXIP Antibodies)-9 in Nonalcoholic Fatty Liver Disease.

  3. The 622C mutant of SIRT1 antisense transcript suppresses hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell line proliferation, decreases the risk of HCC (show FAM126A Antibodies) and is a potential target for gene therapy.

  4. Results found decrease transcriptional levels of Sirt1 in type 2 diabetes with inversely correlated with HDAC3 (show HDAC3 Antibodies) activity, suggesting an imbalance of HDAC3 (show HDAC3 Antibodies)/Sirt1 circuit in T2DM.

  5. Knockdown of SIRT1 suppressed cell proliferation and migration of pancreatic cancer cells. This is the first report to disclose the role of SIRT1 in regulation of pancreatic cancer cell proliferation and migration, which may provide a potential therapeutic target for pancreatic cancer patients.

  6. SIRT6 (show SIRT6 Antibodies), TNF-alpha (show TNF Antibodies), and IFN-gamma (show IFNG Antibodies) were significantly higher in lesional than perilesional and control skin.

  7. We found that tris(2-chloroethyl)phosphate reduced cell viability of L02 and HepG2 cell lines, induced the cell growth arrest, upregulated mRNA and protein levels of SIRT1, and attenuated the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway.

  8. Findings suggest thatSirt1 may regulate the expression of Runx2 (show RUNX2 Antibodies), which is the osteogenic transcription factor, and the production of MMP-13 (show MMP13 Antibodies) from chondrocytes in OA.

  9. SIRT1 inhibits the releases of HMGB1 (show HMGB1 Antibodies) and HSP70 (show HSP70 Antibodies) from human umbilical vein endothelial cells caused by IL-6 (show IL6 Antibodies) and the serum from preeclampsia patient and protects the cells from death.

  10. These results reveal different characteristics in the biological actions between WAT and BAT (show BAAT Antibodies) in obese humans. Increased levels of IL6 (show IL6 Antibodies), UCP1 (show UCP1 Antibodies) and SIRT1 in the BAT (show BAAT Antibodies) were associated with metabolic parameters improvements.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (show TP53 Antibodies) and NF-kappaB (show NFKB1 Antibodies) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (show PPARG Antibodies) to that of ATGL (show PNPLA2 Antibodies) in adipocytes.

  5. CDK5 (show CDK5 Antibodies)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (show FOXO1 Antibodies).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (show MYLIP Antibodies)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (show FABP3 Antibodies) gene in adipocytes, and PPAR gamma (show PPARG Antibodies) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (show FOXO1 Antibodies) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (show SIRT3 Antibodies) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Antigen Profile

Antigen Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1) antibody
  • sirtuin 1 (SRT1) antibody
  • sirtuin 1 (LOC100349271) antibody
  • sirtuin 1 (Sirt1) antibody
  • sirtuin 1 (sirt1) antibody
  • AA673258 antibody
  • SIR2 antibody
  • Sir2a antibody
  • Sir2alpha antibody
  • sir2l1 antibody
  • sirtuin antibody
  • sirtuin 1 antibody

Protein level used designations for anti-Sirtuin 1 (SIRT1) Antibodies

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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