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In adult mouse testes, strong Cubn immunoreactivity was found in the elongating spermatids. In Sertoli cells and peritubular cells, Cubn immunoreactivity was weak throughout the testis development. In the inter-stitium, Cubn immunoreactivity was found in foetal Leydig cells, was weak to negligible in the stem cells and progenitor Leydig cells and was strong in immature and adult Leydig cells.
Cubilin deficiency reduces renal salvage and delivery back to the blood of albumin a (show ALB Proteins)nd apolipoprotein (apo)A-I (show APOA Proteins), which decreases blood levels of albumin and apoA-I (show ALB Proteins)/HD
cubilin and megalin (show LRP2 Proteins) mRNA expression is under epigenetic control
plasma membrane binding of Fgf8 (show FGF8 Proteins), and most likely of the Fgf8 (show FGF8 Proteins) family members Fgf17 (show FGF17 Proteins) and Fgf18 (show FGF18 Proteins), to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity.
Impaired protein endocytosis caused by invalidation of ClC-5 (show CLCN5 Proteins) primarily reflects a trafficking defect of megalin (show LRP2 Proteins) and cubilin in PTC (show PTCH1 Proteins).
Cubilin expression is pronounced in the extraembryonic visceral endoderm of embryos. Cubilin, is also expressed by a subpopulation of cells dispersed within the embryonic endoderm having a migratory morphology.
Amn (show TRAF3 Proteins) is an essential component of the Cubn receptor complex
Cubilin is required for embryonic development and is essential for the formation of somites, and definitive endoderm.
Inactivation of RFC1 (show RFC1 Proteins) impacts the expression of several ligands and interacting proteins in the cubilin-amnionless (show AMN Proteins)-megalin (show LRP2 Proteins) complex that are involved in the maternal-fetal transport of folate and other nutrients.
CUBN SNP rs1801239 (I2984V), previously associated with albuminuria, was significantly associated with T2D-ESRD in blacks.
Tumoral expression of cubilin is a positive predictive marker for treatment of metastatic renal cell cancer patients with sunitinib and sorafenib.
The CUBN haplotypes were associated with an altered gastric cancer risk.
CUBN was associated with albuminuria in type 2 diabetes patients.
The variant rs11254363 of the CUBN gene was associated with a decreased risk of developing congenital heart disease in Han Chinese populations
MA is associated with CVD irrespective of the presence of the CUBN risk allele. These results challenge the concept that albuminuria in the setting of this mutation is benign.
Cubilin haploinsufficiency leads to reduced renal proximal tubular uptake of albumin (show ALB Proteins) and apolipoprotein (apo)A (show APOA Proteins)-I, significantly increasing urinary loss of albumin (show ALB Proteins) and apoA-I (show APOA1 Proteins).
predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL (show NEBL Proteins) common variants in the chromosome 10p13 linkage region
LOS treatment decreased microalbuminuria induced by Cd apparently through a cubilin receptor-dependent mechanism but independent of megalin (show LRP2 Proteins).
Data suggest that endodermal layer of yolk sac (show ADCY10 Proteins) and syncytiotrophoblast/cytotrophoblast cells of placental villi express cubilin mRNA/protein; expression of cubilin mRNA/protein is up-regulated as gestation/placentation progresses.
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
cubilin (intrinsic factor-cobalamin receptor)
, 460 kDa receptor
, glycoprotein 280
, intrinsic factor-cobalamin receptor
, intrinsic factor-vitamin B12 receptor
, cubilin precursor variant 1
, cubilin precursor variant 2
, intestinal intrinsic factor receptor